Potential involvement of KANK1 haploinsufficiency in centrosome aberrations

• Published in: Biochimica et biophysica acta. General subjects Vol. 1868; no. 8; p. 130648
• Main Authors: Imamura, Ikumi, Kiyama, Ryoiti
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.08.2024
• Subjects: Adaptor Proteins, Signal Transducing - genetics; Adaptor Proteins, Signal Transducing - metabolism; apoptosis; Cell division; cell proliferation; Cell Proliferation - genetics; Centrosome; Centrosome - metabolism; centrosomes; Chromosome instability; CRISPR-Cas Systems; Cytoskeletal Proteins - genetics; Cytoskeletal Proteins - metabolism; Gene Editing; guanosinetriphosphatase; Haploinsufficiency; Haploinsufficiency - genetics; Humans; neoplasm cells; plasmids; protein synthesis; renal cell carcinoma; sequence analysis; Tumor suppressor; tumor suppressor genes; Tumor Suppressor Proteins - genetics; Tumor Suppressor Proteins - metabolism; Chromosome instability; Cell division; Tumor suppressor; Centrosome; Haploinsufficiency

KANK1 was found as a tumor suppressor gene based on frequent deletions in renal cell carcinoma and the inhibitory activity of tumor cell proliferation. Previously, we reported that knockdown of KANK1 induced centrosomal amplification, leading to abnormal cell division, through the hyperactivation of...