Nemorubicin and doxorubicin bind the G-quadruplex sequences of the human telomeres and of the c-MYC promoter element Pu22

• Published in: Biochimica et biophysica acta Vol. 1860; no. 6; pp. 1129 - 1138
• Main Authors: Scaglioni, Leonardo, Mondelli, Rosanna, Artali, Roberto, Sirtori, Federico Riccardi, Mazzini, Stefania
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.06.2016
• Subjects: adenine; antineoplastic activity; Antineoplastic Agents - chemistry; c-MYC; Daunomycins; DNA; DNA-binding drugs; doxorubicin; Doxorubicin - analogs & derivatives; Doxorubicin - chemistry; electrospray ionization mass spectrometry; G-quadruplex; G-Quadruplexes; gene overexpression; Genes, myc; guanine; humans; ligands; Magnetic Resonance Spectroscopy; mechanism of action; Models, Molecular; Molecular modeling; NMR; nuclear magnetic resonance spectroscopy; oncogenes; promoter regions; Promoter Regions, Genetic; Spectrometry, Mass, Electrospray Ionization; Telomere; telomeres; transcription (genetics); A; DNA-binding drugs; c-MYC; G; G-quadruplex; nemo; TOCSY; doxo; daunomycins; DOSY; Q; NMR; R=[drug]/[DNA]; T; Molecular modeling; ESI–MS; NOESY; HSQC; Daunomycins

Intra-molecular G-quadruplex structures are present in the guanine rich regions of human telomeres and were found to be prevalent in gene promoters. More recently, the targeting of c-MYC transcriptional control has been suggested, because the over expression of the c-MYC oncogene is one of the most...