5-Hydroxytryptamine activates a 5-HT/c-Myc/SLC6A4 signaling loop in non–small cell lung cancer

• Published in: Biochimica et biophysica acta. General subjects Vol. 1866; no. 4; p. 130093
• Main Authors: Tu, Yuan, Yao, Shengping, Chen, Qiong, Li, Wenqin, Song, Yinghui, Zhang, Pei
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.04.2022
• Subjects: 5-Hydroxytryptamine; c-Myc; carcinogenesis; Carcinogenesis - genetics; Carcinoma, Non-Small-Cell Lung - drug therapy; Cell Line, Tumor; Cell Proliferation - genetics; fluorescent antibody technique; genome; Humans; immunohistochemistry; lung neoplasms; Lung Neoplasms - genetics; metastasis; neoplasm progression; neurotransmitters; patients; protein synthesis; psychological stress; Serotonin; Serotonin Plasma Membrane Transport Proteins; SLC6A4; therapeutics; transcription factors; TRIB3; 5-Hydroxytryptamine; TRIB3; c-Myc; SLC6A4

Psychological stress is a crucial driver of tumorigenesis and cancer metastasis. The impact of the stress-associated neurotransmitter 5-hydroxytryptamine (5-HT) on tumor progression is poorly understood. We aimed to identify the role of 5-HT in the pathogenesis of non–small cell lung cancer (NSCLC)...