The shedding-derived soluble receptor for advanced glycation endproducts sustains inflammation during acute Pseudomonas aeruginosa lung infection

• Published in: Biochimica et biophysica acta. General subjects Vol. 1861; no. 2; pp. 354 - 364
• Main Authors: Antonelli, Antonella, Di Maggio, Stefania, Rejman, Joanna, Sanvito, Francesca, Rossi, Alice, Catucci, Alessandro, Gorzanelli, Andrea, Bragonzi, Alessandra, Bianchi, Marco E., Raucci, Angela
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.02.2017
• Subjects: ADAM10 Protein - metabolism; advanced glycation end products; Animals; cross infection; epithelial cells; Glycation End Products, Advanced - metabolism; Inflammation; Inflammation - metabolism; Inflammation - microbiology; Lung - metabolism; Lung - microbiology; Mice; Mice, Inbred C57BL; microbial growth; microbial load; neutrophils; Neutrophils - metabolism; P. aeruginosa; pathogenesis; pathogens; patients; pneumonia; Pneumoniae; proteinases; proteolysis; Pseudomonas aeruginosa; Pseudomonas aeruginosa - pathogenicity; Pseudomonas Infections - metabolism; Pseudomonas Infections - microbiology; RAGE shedding; Receptor for Advanced Glycation End Products - metabolism; Soluble RAGE; Inflammation; Soluble RAGE; Pneumoniae; RAGE shedding; P. aeruginosa

The membrane-bound isoform of the receptor for advanced glycation end products (FL-RAGE) is primarily expressed by alveolar epithelial cells and undergoes shedding by the protease ADAM10, giving rise to soluble cleaved RAGE (cRAGE). RAGE has been associated with the pathogenesis of several acute and...