Novel signalling mechanisms and targets in renal ischaemia and reperfusion injury

• Published in: Acta Physiologica Vol. 208; no. 1; pp. 25 - 40
• Main Authors: Kusch, A., Hoff, U., Bubalo, G., Zhu, Y., Fechner, M., Schmidt-Ullrich, R., Marko, L., Müller, D. N., Schmidt-Ott, K. M., Gürgen, D., Blum, M., Schunck, W.-H., Dragun, D.
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.05.2013; Wiley Subscription Services, Inc
• Subjects: Acute Kidney Injury - genetics; Acute Kidney Injury - metabolism; Acute Kidney Injury - physiopathology; Acute Kidney Injury - therapy; Animals; Autoimmune diseases; Cells; Cytochrome P-450 Enzyme System - metabolism; eicosanoids; Eicosanoids - metabolism; Humans; ischaemia; Kidney - blood supply; Kidney - drug effects; Kidney - metabolism; kidney reperfusion injury; Kinases; Lysophospholipids - metabolism; Medical research; Molecular Targeted Therapy; NF-kappa B - metabolism; NFĸB; PKC; Prognosis; Protein Kinase C - metabolism; Proteins; Receptors, Lysosphingolipid - metabolism; Renal Circulation; Reperfusion Injury - genetics; Reperfusion Injury - metabolism; Reperfusion Injury - physiopathology; Reperfusion Injury - therapy; signal transduction; Signal Transduction - drug effects; Sphingosine - analogs & derivatives; Sphingosine - metabolism; sphingosine 1-P

Acute kidney injury (AKI) induced by ischaemia and reperfusion (I/R) injury is a common and severe clinical problem. Vascular dysfunction, immune system activation and tubular epithelial cell injury contribute to functional and structural deterioration. The search for novel therapeutic interventions...