Gal-1 (Galectin-1) Upregulation Contributes to Abdominal Aortic Aneurysm Progression by Enhancing Vascular Inflammation

• Published in: Arteriosclerosis, thrombosis, and vascular biology Vol. 41; no. 1; pp. 331 - 345
• Main Authors: Chiang, Ming-Tsai, Chen, I-Ming, Hsu, Fu-Fei, Chen, Yen-Hui, Tsai, Min-Shao, Hsu, Yaw-Wen, Leu, Hsin-Bang, Huang, Po-Hsun, Chen, Jaw-Wen, Liu, Fu-Tong, Chen, Ying-Hwa, Chau, Lee-Young
• Format: Journal Article
• Language: English
• Published: United States Lippincott Williams & Wilkins 01.01.2021; American Heart Association, Inc
• Subjects: Adventitia - metabolism; Adventitia - pathology; Angiotensin II; Animals; Aorta, Abdominal - metabolism; Aorta, Abdominal - pathology; Aortic Aneurysm, Abdominal - chemically induced; Aortic Aneurysm, Abdominal - metabolism; Aortic Aneurysm, Abdominal - pathology; Aortitis - chemically induced; Aortitis - metabolism; Aortitis - pathology; Case-Control Studies; Cells, Cultured; Cytokines - metabolism; Disease Models, Animal; Disease Progression; Extracellular Matrix - metabolism; Extracellular Matrix - pathology; Fibroblasts - metabolism; Fibroblasts - pathology; Galectin 1 - blood; Galectin 1 - deficiency; Galectin 1 - genetics; Galectin 1 - metabolism; Humans; Inflammation Mediators - metabolism; Macrophages, Peritoneal - metabolism; Macrophages, Peritoneal - pathology; Male; Matrix Metalloproteinase 9 - metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout, ApoE; Mitogen-Activated Protein Kinases - metabolism; Muscle, Smooth, Vascular - metabolism; Muscle, Smooth, Vascular - pathology; Myocytes, Smooth Muscle - metabolism; Myocytes, Smooth Muscle - pathology; Signal Transduction; Up-Regulation; Vascular Remodeling; matrix metalloprotease; galectin 1; aorta; cytokines; incidence; aortic aneurysm, abdominal

OBJECTIVE:Abdominal aortic aneurysm (AAA) is a vascular degenerative disease causing sudden rupture of aorta and significant mortality in elders. Nevertheless, no prognostic and therapeutic target is available for disease management. Gal-1 (galectin-1) is a β-galactoside–binding lectin constitutivel...