Gastric Emptying, Incretin Hormone Secretion, and Postprandial Glycemia in Cystic Fibrosis—Effects of Pancreatic Enzyme Supplementation

• Published in: The journal of clinical endocrinology and metabolism Vol. 96; no. 5; pp. E851 - E855
• Main Authors: Kuo, Paul, Stevens, Julie E., Russo, Antonietta, Maddox, Anne, Wishart, Judith M., Jones, Karen L., Greville, Hugh, Hetzel, David, Chapman, Ian, Horowitz, Michael, Rayner, Christopher K.
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.05.2011; Copyright by The Endocrine Society
• Subjects: Adult; Blood glucose; Blood Glucose - metabolism; Blood levels; Body mass index; Clinical trials; Cystic fibrosis; Cystic Fibrosis - blood; Cystic Fibrosis - physiopathology; Dietary Carbohydrates - pharmacology; Dietary Fats - pharmacology; Double-Blind Method; Dumping syndrome; Enzymes; Female; Gastric emptying; Gastric Emptying - physiology; Gastric Inhibitory Polypeptide - blood; GIP protein; Glucagon; Glucagon - blood; Glucagon-like peptide 1; Glucagon-Like Peptide 1 - blood; Glucose; Humans; Hyperglycemia; Hyperglycemia - metabolism; Incretins - metabolism; Insulin - blood; Lipase - therapeutic use; Malabsorption; Male; Pancreas; Pancreas - enzymology; Placebos; Scintigraphy; Secretion; Supplements; Young Adult

Context:Postprandial hyperglycemia is an important clinical problem in cystic fibrosis (CF), but the contribution of fat malabsorption, rapid gastric emptying, and the incretin axis has not been widely considered.Objective:The aim of this study was to evaluate these aspects of gut function in nondia...