Saliva of the lyme disease vector, Ixodes dammini, blocks cell activation by a nonprostaglandin E2-dependent mechanism

• Published in: The Journal of experimental medicine Vol. 180; no. 3; pp. 1077 - 1085
• Main Authors: URIOSTE, S, HALL, L. R, TELFORD, S. R, TITUS, R. G
• Format: Journal Article
• Language: English
• Published: New York, NY Rockefeller University Press 01.09.1994; The Rockefeller University Press
• Subjects: Animals; Biological and medical sciences; Concanavalin A - pharmacology; Dinoprostone - pharmacology; Female; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Immunobiology; Interleukin-2 - biosynthesis; Lyme Disease - immunology; Lyme Disease - transmission; Lymphocyte Activation; Macrophages - metabolism; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Modulation of the immune response (stimulation, suppression); Nitric Oxide - biosynthesis; Saliva - immunology; Suppressor Factors, Immunologic - analysis; T-Lymphocytes - immunology; Ticks - immunology; Parasitiformes; Lyme disease; Animal model; Host parasite relation; Borrelia infection; Rodentia; Infection; Proteins; Arachnida; Vertebrata; Immunosuppression; Ixodes dammini; Mammalia; Acari; Mouse; Ixodida; Arthropoda; Bacteriosis; Invertebrata; Mechanism of action; Saliva; Vector; Ixodidae; Spirachaetosis

Tick-borne pathogens would appear to be vulnerable to vertebrate host immune responses during the protracted duration of feeding required by their vectors. However, tick salivary components deposited during feeding may inhibit hemostasis and induce immunosuppression. The mode of action and the natur...