Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a secondary analysis of microbiological results from a randomized clinical trial

• Published in: Journal of clinical periodontology Vol. 41; no. 4; pp. 366 - 376
• Main Authors: Soares, Geisla M. S., Mendes, Juliana A. V., Silva, Maike P., Faveri, Marcelo, Teles, Ricardo, Socransky, Sigmund S., Wang, Xiaoshan, Figueiredo, Luciene C., Feres, Magda
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.04.2014
• Subjects: Adult; amoxicillin; Amoxicillin - administration & dosage; Amoxicillin - therapeutic use; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - therapeutic use; Anti-Infective Agents - administration & dosage; Anti-Infective Agents - therapeutic use; Anti-Infective Agents, Local - administration & dosage; Anti-Infective Agents, Local - therapeutic use; Antibiotics; Bacteria - drug effects; Bacteria - isolation & purification; Bacterial Load - drug effects; Chlorhexidine - administration & dosage; Chlorhexidine - therapeutic use; chronic periodontitis; Chronic Periodontitis - drug therapy; Chronic Periodontitis - microbiology; Chronic Periodontitis - therapy; Clinical outcomes; Combined Modality Therapy; Dental Plaque - microbiology; Dental Scaling - methods; Dentistry; Double-Blind Method; Drug Combinations; Female; Follow-Up Studies; Gum disease; Humans; Male; metronidazole; Metronidazole - administration & dosage; Metronidazole - therapeutic use; microbiology; Middle Aged; Mouthwashes - administration & dosage; Mouthwashes - therapeutic use; Periodontal Attachment Loss - drug therapy; Periodontal Attachment Loss - microbiology; Periodontal Attachment Loss - therapy; periodontal disease; Periodontal Pocket - drug therapy; Periodontal Pocket - microbiology; Periodontal Pocket - therapy; periodontitis; Placebos; Root Planing - methods; Treatment Outcome

Aim To evaluate the changes occurring in the subgingival microbial profile of subjects with generalized chronic periodontitis (ChP) treated by scaling and root planing (SRP) alone or with metronidazole (MTZ) or MTZ + amoxicillin (AMX). A secondary aim was to examine a possible added effect of chlorh...