Effects of pyruvate administration on mRNA expression of inflammatory cytokines in adipose tissue and whole‐body glucose metabolism in male mice

• Published in: Physiological reports Vol. 13; no. 15; pp. e70362 - n/a
• Main Authors: Ando, Taichi, Takeda, Reo, Kano, Ryotaro, Kusano, Tatsuya, Nonaka, Yudai, Kano, Yutaka, Hoshino, Daisuke
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.08.2025; John Wiley and Sons Inc; Wiley
• Subjects: Adipocytes; Adipose tissue; Adipose Tissue - drug effects; Adipose Tissue - metabolism; Adipose Tissue, White - drug effects; Adipose Tissue, White - metabolism; Animals; Body fat; Body weight; Cytokines; Cytokines - genetics; Cytokines - metabolism; Dehydrogenases; Diet; Diet, High-Fat - adverse effects; Experiments; Fat metabolism; Gene expression; Glucose; Glucose - metabolism; Glucose tolerance; High fat diet; IL‐6; Inflammation; Insulin resistance; Interleukin 6; Interleukin-6 - genetics; Interleukin-6 - metabolism; Intervention; lactate; Lactic acid; Macrophages; Male; Metabolism; Mice; Mice, Inbred C57BL; Nutrition research; obesity; Original; Plasma; Pyruvic acid; Pyruvic Acid - administration & dosage; Pyruvic Acid - pharmacology; Regular Manuscript; RNA, Messenger - genetics; RNA, Messenger - metabolism; Sodium pyruvate; Tumor Necrosis Factor-alpha - genetics; Tumor Necrosis Factor-alpha - metabolism; Tumor necrosis factor-TNF; white adipose tissue; St Louis Missouri; United States > US; Japan; white adipose tissue; lactate; obesity; IL‐6

Pyruvate administration leads to the accumulation of intracellular lactate in adipocytes and affects inflammatory cytokine production and whole‐body glucose metabolism. Therefore, the purpose of this study was to determine whether pyruvate administration improves the dysfunction of glucose metabolis...