p53 isoform Δ113p53/Δ133p53 promotes DNA double-strand break repair to protect cell from death and senescence in response to DNA damage

• Published in: Cell research Vol. 25; no. 3; pp. 351 - 369
• Main Authors: Gong, Lu, Gong, Hongjian, Pan, Xiao, Chang, Changqing, Ou, Zhao, Ye, Shengfan, Yin, Le, Yang, Lina, Tao, Ting, Zhang, Zhenhai, Liu, Cong, Lane, David P, Peng, Jinrong, Chen, Jun
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.03.2015; Nature Publishing Group
• Subjects: 631/337/1427/2122; 631/80/82; 692/699/67/1059/485; 692/699/67/581; Animals; Animals, Genetically Modified; Apoptosis - genetics; Biomedical and Life Sciences; Cell Biology; Cell Line; Cellular Senescence - genetics; DNA - genetics; DNA Breaks, Double-Stranded - radiation effects; DNA Ligase ATP; DNA Ligases - biosynthesis; DNA Repair - genetics; DNA-Binding Proteins - biosynthesis; DNA-Binding Proteins - metabolism; G2 Phase Cell Cycle Checkpoints - genetics; G2 Phase Cell Cycle Checkpoints - radiation effects; Humans; Life Sciences; Original; original-article; Promoter Regions, Genetic - genetics; Protein Binding; Protein Isoforms - genetics; Rad51 Recombinase - biosynthesis; RNA Interference; RNA, Small Interfering; Tumor Suppressor Protein p53 - genetics; Zebrafish; Zebrafish Proteins - biosynthesis; Zebrafish Proteins - genetics; SSA; senescence; Δ113p53/Δ133p53; cell death; p53 isoform; HR; NHEJ

The inhibitory role of p53 in DNA double-strand break (DSB) repair seems contradictory to its tumor-suppressing property. The p53 isoform Δ113p53/Δ133p53 is a p53 target gene that antagonizes p53 apoptotic activity. However, information on its functions in DNA damage repair is lacking. Here we repor...