Stimulus‐induced brain lactate: effects of aging and prolonged wakefulness

• Published in: Journal of sleep research Vol. 13; no. 2; pp. 111 - 119
• Main Authors: Urrila, Anna S., Hakkarainen, Antti, Heikkinen, Sami, Vuori, Kim, Stenberg, Dag, Häkkinen, Anna‐Maija, Lundbom, Nina, Porkka‐Heiskanen, Tarja
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01.06.2004
• Subjects: 1H MRS; Adult; Age Factors; Aged; aging; Aging - physiology; Brain - anatomy & histology; Brain - metabolism; Cognition - physiology; cognitive stimulation; Female; Humans; lactate; Lactic Acid - metabolism; Magnetic Resonance Spectroscopy; Middle Aged; prolonged wakefulness; Verbal Behavior; Vocabulary; Wakefulness - physiology

Summary Both aging and sleep deprivation disturb the functions of the frontal lobes. Deficits in brain energy metabolism have been reported in these conditions. Neurons use not only glucose but also lactate as their energy substrate. The physiological response to elevated neuronal activity is a tran...