Elevated levels of mitochondrion‐associated autophagy inhibitor LRPPRC are associated with poor prognosis in patients with prostate cancer

• Published in: Cancer Vol. 120; no. 8; pp. 1228 - 1236
• Main Authors: Jiang, Xianhan, Li, Xun, Huang, Hai, Jiang, Funeng, Lin, Zhuoyuan, He, Huichan, Chen, Yanru, Yue, Fei, Zou, Jing, He, Yongzhong, You, Pan, Wang, Wenwei, Yang, Weiqing, Zhao, Haibo, Lai, Yiming, Wang, Fen, Zhong, Weide, Liu, Leyuan
• Format: Journal Article
• Language: English
• Published: Hoboken, NJ Wiley-Blackwell 15.04.2014
• Subjects: Aged; Aged, 80 and over; Animals; autophagy; Autophagy - physiology; benign prostatic hyperplasia; Biological and medical sciences; biomarker; cancer prognosis; Humans; Immunohistochemistry; leucine‐rich pentatricopeptide repeat motif‐containing protein (LRPPRC); Male; Medical sciences; Mice; Middle Aged; mitochondria; Multiple tumors. Solid tumors. Tumors in childhood (general aspects); Neoplasm Proteins - analysis; Neoplasms, Hormone-Dependent - chemistry; Nephrology. Urinary tract diseases; phosphatase and tensin homolog (PTEN); Prognosis; prostate adenocarcinomas; Prostatic Hyperplasia - metabolism; prostatic intraepithelial neoplasia; Prostatic Neoplasms - chemistry; Prostatic Neoplasms - mortality; Prostatic Neoplasms - pathology; PTEN Phosphohydrolase - physiology; Tumors; Tumors of the urinary system; Urinary tract. Prostate gland; Prognosis; Prostate disease; Biological marker; Autophagy; Mitochondria; Association; Cancerology; Benign prostatic hyperplasia; PTEN Gene; Benign neoplasm; Male genital diseases; Tumor suppressor gene; Human; Premalignant lesion; Urinary system disease; Prostate intraepithelial neoplasia; phosphatase and tensin homolog (PTEN); Malignant tumor; biomarker; Prostate adenocarcinoma; cancer prognosis; Protein; prostatic intraepithelial neoplasia; Leucine-rich repeat region; prostate adenocarcinomas; Inhibitor; Prostate cancer; leucine-rich pentatricopeptide repeat motif-containing protein (LRPPRC); Cancer; autophagy; mitochondria; benign prostatic hyperplasia

BACKGROUND Autophagy has recently been found to play important roles in tumorigenesis and leucine‐rich pentatricopeptide repeat motif‐containing protein (LRPPRC) has been identified as an inhibitor that suppresses autophagy and mitophagy and maintains mitochondrial activity. The authors hypothesized...