Cocaine- or stress-induced metaplasticity of LTP in the dorsal and ventral hippocampus

• Published in: Hippocampus Vol. 24; no. 5; pp. 577 - 590
• Main Authors: Keralapurath, Madhusudhanan M., Clark, Jason K., Hammond, Sherri, Wagner, John J.
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.05.2014; Wiley Subscription Services, Inc
• Subjects: Animals; cocaine; Cocaine - pharmacology; Corticosterone - blood; Dopamine Uptake Inhibitors - pharmacology; Drug Administration Schedule; Excitatory Postsynaptic Potentials - drug effects; hippocampus; Hippocampus - anatomy & histology; Hippocampus - drug effects; Hormone Antagonists - pharmacology; In Vitro Techniques; Long-Term Potentiation - drug effects; Male; metaplasticity; Mifepristone - pharmacology; Mineralocorticoid Receptor Antagonists; Motor Activity - drug effects; Naltrexone - analogs & derivatives; Naltrexone - pharmacology; Rats; Rats, Sprague-Dawley; Spironolactone - pharmacology; stress; Stress, Psychological - blood; Stress, Psychological - pathology; stress; hippocampus; cocaine; metaplasticity

ABSTRACT Despite the well documented role of the hippocampus in various modes of drug reinstatement behavior, the persisting effects of in vivo cocaine exposure on hippocampal synaptic plasticity are not sufficiently understood. In this report we investigated the effects of cocaine conditioning on l...