Phosphorylation of the conserved C‐terminal domain of ribosomal P‐proteins impairs the mode of interaction with plant toxins

• Published in: FEBS letters Vol. 595; no. 17; pp. 2221 - 2236
• Main Authors: Horbowicz‐Drożdżal, Patrycja, Kamel, Karol, Kmiecik, Sebastian, Borkiewicz, Lidia, Tumer, Nilgun E., Shaw, Pang‐Chui, Tchórzewski, Marek, Grela, Przemysław
• Format: Journal Article
• Language: English
• Published: 01.09.2021
• Subjects: amino acid sequences; bioactive properties; interferometry; P1/P2 proteins; phosphorylation; ribosomal stalk; ribosomes; ribosome‐inactivating protein; ricin A chain; trichosanthin

The ribosome is subjected to post‐translational modifications, including phosphorylation, that affect its biological activity. Among ribosomal elements, the P‐proteins undergo phosphorylation within the C terminus, the element which interacts with trGTPases or ribosome‐inactivating proteins (RIPs);...