Allosteric effects on oxidative and nitrosative reactions of cell-free hemoglobins

• Published in: IUBMB life Vol. 59; no. 8-9; p. 498
• Main Authors: Bonaventura, Celia, Henkens, Robert, Alayash, Abdu I, Crumbliss, Alvin L
• Format: Journal Article
• Language: English
• Published: England 2007
• Subjects: Allosteric Regulation; Cell-Free System; Hemoglobins - metabolism; Humans; Nitrosation; Oxidative Stress

A review of the oxidative and nitrosative reactions of cell-free hemoglobin-based oxygen carriers (HBOCs) shows that these reactions are intimately linked and are subject to allosteric control. Cross-linking reactions used to produce HBOCs introduce conformational constraints and result in Hbs with...