Protein Turnover in Malnourished Elderly Subjects: The Effects of Refeeding
A primed constant-rate infusion of L-(l-14C)-leucine was used to assess protein flux, synthesis, and breakdown in a group of malnourished elderly subects (n = 9) and a group of age-matched healthy elderly control subjects (n = 9). No significant differences between the two groups were observed in me...
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| Published in | Age and ageing Vol. 18; no. 4; pp. 235 - 240 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Oxford University Press
01.07.1989
Oxford Publishing Limited (England) |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0002-0729 1468-2834 |
| DOI | 10.1093/ageing/18.4.235 |
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| Abstract | A primed constant-rate infusion of L-(l-14C)-leucine was used to assess protein flux, synthesis, and breakdown in a group of malnourished elderly subects (n = 9) and a group of age-matched healthy elderly control subjects (n = 9). No significant differences between the two groups were observed in measures of protein metabolism. Four out of six malnourished subjects, restudied after a period of dietary replenishment, showed non-significant increases in protein synthesis and breakdown. Plasma insulin concentrations were significantly suppressed (p < 0.05) and plasma growth hormone and cortisol concentrations significantly elevated (p < 0.05) in the malnourished subjects before and after refeeding compared with the healthy elderly controls. |
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| AbstractList | A primed constant-rate infusion of L-(l-14C)-leucine was used to assess protein flux, synthesis, and breakdown in a group of malnourished elderly subjects (n = 9) and a group of age-matched healthy elderly control subjects (n = 9). No significant differences between the two groups were observed in measures of protein metabolism. Four out of six malnourished subjects, restudied after a period of dietary replenishment, showed non-significant increases in protein synthesis and breakdown. Plasma insulin concentrations were significantly suppressed (p less than 0.05) and plasma growth hormone and cortisol concentrations significantly elevated (p less than 0.05) in the malnourished subjects before and after refeeding compared with the healthy elderly controls. A primed constant-rate infusion of L-(l-14C)-leucine was used to assess protein flux, synthesis, and breakdown in a group of malnourished elderly subects (n = 9) and a group of age-matched healthy elderly control subjects (n = 9). No significant differences between the two groups were observed in measures of protein metabolism. Four out of six malnourished subjects, restudied after a period of dietary replenishment, showed non-significant increases in protein synthesis and breakdown. Plasma insulin concentrations were significantly suppressed (p < 0.05) and plasma growth hormone and cortisol concentrations significantly elevated (p < 0.05) in the malnourished subjects before and after refeeding compared with the healthy elderly controls. The effect of dietary inadequacy on protein metabolism in malnourished elderly subjects as compared to healthy elderly subjects is discussed. Of the two groups studied, no significant differences were observed in measures of protein metabolism. A primed constant-rate infusion of L-(l-14C)-leucine was used to assess protein flux, synthesis, and breakdown in a group of malnourished elderly subjects (n = 9) and a group of age-matched healthy elderly control subjects (n = 9). No significant differences between the two groups were observed in measures of protein metabolism. Four out of six malnourished subjects, restudied after a period of dietary replenishment, showed non-significant increases in protein synthesis and breakdown. Plasma insulin concentrations were significantly suppressed (p less than 0.05) and plasma growth hormone and cortisol concentrations significantly elevated (p less than 0.05) in the malnourished subjects before and after refeeding compared with the healthy elderly controls.A primed constant-rate infusion of L-(l-14C)-leucine was used to assess protein flux, synthesis, and breakdown in a group of malnourished elderly subjects (n = 9) and a group of age-matched healthy elderly control subjects (n = 9). No significant differences between the two groups were observed in measures of protein metabolism. Four out of six malnourished subjects, restudied after a period of dietary replenishment, showed non-significant increases in protein synthesis and breakdown. Plasma insulin concentrations were significantly suppressed (p less than 0.05) and plasma growth hormone and cortisol concentrations significantly elevated (p less than 0.05) in the malnourished subjects before and after refeeding compared with the healthy elderly controls. A primed constant-rate infusion of L-([1-sup.14.C])-leucine was used to assess protein flux, synthesis, and breakdown in a group of malnourished elderly subects (n = 9) and a group of age-matched healthy elderly control subjects (n = 9). No significant differences between the two groups were observed in measures of protein metabolism. Four out of six malnourished subjects, restudied after a period of dietary replenishment, showed non-significant increases in protein synthesis and breakdown. Plasma insulin concentrations were significantly suppressed (p < 0.05) and plasma growth hormone and cortisol concentrations significantly elevated (p < 0.05) in the malnourished subjects before and after refeeding compared with the healthy elderly controls. |
| Audience | Academic |
| Author | BEAUMONT, D. LEHMANN, A. B. JAMES, O. F. W. |
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| Copyright | COPYRIGHT 1989 Oxford University
Press Copyright Oxford University Press(England) Jul 1989 |
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| Snippet | A primed constant-rate infusion of L-(l-14C)-leucine was used to assess protein flux, synthesis, and breakdown in a group of malnourished elderly subects (n =... A primed constant-rate infusion of L-(l-14C)-leucine was used to assess protein flux, synthesis, and breakdown in a group of malnourished elderly subjects (n =... A primed constant-rate infusion of L-([1-sup.14.C])-leucine was used to assess protein flux, synthesis, and breakdown in a group of malnourished elderly... The effect of dietary inadequacy on protein metabolism in malnourished elderly subjects as compared to healthy elderly subjects is discussed. Of the two groups... |
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| SubjectTerms | Age Factors Aged Aged, 80 and over Body Weight Diet Dietary Proteins - administration & dosage Dietary Proteins - metabolism Elderly Food and nutrition Humans Leucine - metabolism Male Malnutrition Medical research Metabolism Nutrition Disorders - metabolism Nutrition disorders in old age Older people Protein synthesis Proteins Sex Factors Synthesis |
| Title | Protein Turnover in Malnourished Elderly Subjects: The Effects of Refeeding |
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