Image-based finite-element modeling of the human femur

• Published in: Computer methods in biomechanics and biomedical engineering Vol. 23; no. 14; pp. 1138 - 1161
• Main Authors: Falcinelli, Cristina, Whyne, Cari
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.11.2020; Taylor & Francis Ltd
• Subjects: Accuracy; Biomechanical Phenomena; biomechanical response; Biomechanics; Biomedical materials; Bone Density; clinical studies; computed tomography; Diagnostic systems; failure criteria; Femur; Femur - anatomy & histology; Femur - diagnostic imaging; femur strength; Finite Element Analysis; Finite element method; Fractures; human femur; Humans; Imaging, Three-Dimensional; in vitro models; Mathematical models; Metastases; Model accuracy; Numerical models; Osteoporosis; Risk assessment; Subject-specific finite element modeling; Tomography, X-Ray Computed; Workflow; computed tomography; in vitro models; Subject-specific finite element modeling; biomechanical response; femur strength; clinical studies; failure criteria; human femur

Fracture is considered a critical clinical endpoint in skeletal pathologies including osteoporosis and bone metastases. However, current clinical guidelines are limited with respect to identifying cases at high risk of fracture, as they do not account for many mechanical determinants that contribute...