Pharmacologic basis of the antiarrhythmic and hemodynamic effects of sotalol

• Published in: The American journal of cardiology Vol. 72; no. 4; pp. A27 - A37
• Main Authors: Antonaccio, Michael J., Gomoll, Allen
• Format: Journal Article Conference Proceeding
• Language: English
• Published: New York, NY Elsevier Inc 12.08.1993; Elsevier; Elsevier Limited
• Subjects: Action Potentials - drug effects; Animals; Anti-Arrhythmia Agents - pharmacology; Antiarythmic agents; Biological and medical sciences; Cardiac arrhythmia; Cardiovascular system; Dose-Response Relationship, Drug; Heart - drug effects; Heart - physiology; Hemodynamics - drug effects; Humans; Medical research; Medical sciences; Myocardial Contraction - drug effects; Pharmacology; Pharmacology. Drug treatments; Prescription drugs; Sotalol - pharmacology; In vivo; Hemodynamics; In vitro; Biological activity; Antiarrhythmia agent; Beta blocking agent

Sotalol is a competitive β adrenoceptor antagonist devoid of membrane-stabilizing activity and intrinsic sympathomimetic activity that has no preferential actions on β 1 or β 2 responses. No other tested receptor systems are affected by sotalol. In addition to having class II (β blockade) effects, s...