Effects of chitooligosaccharide-zinc on the ovarian function of mice with premature ovarian failure via the SESN2/NRF2 signaling pathway
Chitooligosaccharide-zinc (COS·Zn) is a powerful anti-oxidant and anti-aging scavenger, whose anti-oxidative ability immensely exceeds vitamin C. Therefore, this study was aimed to investigate the protective effects of COS·Zn against premature ovarian failure (POF) and potential mechanisms. Female K...
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Published in | Chinese journal of natural medicines Vol. 19; no. 10; pp. 721 - 731 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
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Elsevier B.V
01.10.2021
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Abstract | Chitooligosaccharide-zinc (COS·Zn) is a powerful anti-oxidant and anti-aging scavenger, whose anti-oxidative ability immensely exceeds vitamin C. Therefore, this study was aimed to investigate the protective effects of COS·Zn against premature ovarian failure (POF) and potential mechanisms. Female KM adult mice were divided into the following groups: a treatment group (150 mg·kg−1·d−1 COS·Zn), a treatment group (300 mg·kg−1·d−1 COS·Zn), a prevention group, two control groups and two CY/BUS groups. COS·Zn (150, 300 mg·kg−1·d−1) and COS·Zn (300 mg·kg−1·d−1) were therapeutically and preventatively administered to POF mice in the treatment and prevention studies, respectively. All the groups were administered for 21 days. Fewer primary and secondary follicles were observed in the COS·Zn-treated groups (including the treatment and prevention groups) than those of the control groups. Meanwhile, the ovarian index and the levels of FSH and LH notably increased in the treatment and prevention groups compared with those in the CY/BUS group. The levels of MVH, OCT4 and PCNA in the treatment group (300·kg−1·d−1 COS·Zn) and MVH in the prevention group remarkably increased compared with those in the CY/BUS groups. Meanwhile, the levels of P53 and P16 protein were down-regulated in the treatment and prevention groups compared with those in the CY/BUS groups. Additionally, the amounts of Sestrin2 (SESN2) and SOD2 protein were obviously higher in the treatment group (150 mg·kg−1·d−1 COS·Zn) than those in the CY/BUS groups. Similarly, the amounts of NRF2 and SESN2 protein were up-regulated in the prevention group. Besides, an increased GSH level was observed in the two treatment groups, compared with that in the CY/BUS groups, and the same trend was also present in the prevention group. Taken together, COS·Zn improves the ovarian and follicular development through regulating the SESN2/NRF2 signaling pathway. These results suggest the role of COS·Zn as a novel agent for the treatment and prevention of POF. |
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AbstractList | Chitooligosaccharide-zinc (COS·Zn) is a powerful anti-oxidant and anti-aging scavenger, whose anti-oxidative ability immensely exceeds vitamin C. Therefore, this study was aimed to investigate the protective effects of COS·Zn against premature ovarian failure (POF) and potential mechanisms. Female KM adult mice were divided into the following groups: a treatment group (150 mg·kg−1·d−1 COS·Zn), a treatment group (300 mg·kg−1·d−1 COS·Zn), a prevention group, two control groups and two CY/BUS groups. COS·Zn (150, 300 mg·kg−1·d−1) and COS·Zn (300 mg·kg−1·d−1) were therapeutically and preventatively administered to POF mice in the treatment and prevention studies, respectively. All the groups were administered for 21 days. Fewer primary and secondary follicles were observed in the COS·Zn-treated groups (including the treatment and prevention groups) than those of the control groups. Meanwhile, the ovarian index and the levels of FSH and LH notably increased in the treatment and prevention groups compared with those in the CY/BUS group. The levels of MVH, OCT4 and PCNA in the treatment group (300·kg−1·d−1 COS·Zn) and MVH in the prevention group remarkably increased compared with those in the CY/BUS groups. Meanwhile, the levels of P53 and P16 protein were down-regulated in the treatment and prevention groups compared with those in the CY/BUS groups. Additionally, the amounts of Sestrin2 (SESN2) and SOD2 protein were obviously higher in the treatment group (150 mg·kg−1·d−1 COS·Zn) than those in the CY/BUS groups. Similarly, the amounts of NRF2 and SESN2 protein were up-regulated in the prevention group. Besides, an increased GSH level was observed in the two treatment groups, compared with that in the CY/BUS groups, and the same trend was also present in the prevention group. Taken together, COS·Zn improves the ovarian and follicular development through regulating the SESN2/NRF2 signaling pathway. These results suggest the role of COS·Zn as a novel agent for the treatment and prevention of POF. |
Author | CAO, Xiu-Ping LIU, Jiang-Ying ZHENG, Yue-Hui XU, Jia-Yu LI, Jia HUANG, Jian FU, Jia-Cheng CHEN, Yu-Hang |
Author_xml | – sequence: 1 givenname: Jia surname: LI fullname: LI, Jia organization: Medical Experimental Teaching Center, Nanchang University, Nanchang 330006, China – sequence: 2 givenname: Yu-Hang surname: CHEN fullname: CHEN, Yu-Hang organization: The Second Clinical Medical College, Nanchang University, Nanchang 330006, China – sequence: 3 givenname: Jia-Yu surname: XU fullname: XU, Jia-Yu organization: The First Clinical Medical College, Nanchang University, Nanchang 330006, China – sequence: 4 givenname: Jiang-Ying surname: LIU fullname: LIU, Jiang-Ying organization: The First Clinical Medical College, Nanchang University, Nanchang 330006, China – sequence: 5 givenname: Jia-Cheng surname: FU fullname: FU, Jia-Cheng organization: The Second Clinical Medical College, Nanchang University, Nanchang 330006, China – sequence: 6 givenname: Xiu-Ping surname: CAO fullname: CAO, Xiu-Ping organization: School of Basic Medicine, Nanchang University, Nanchang 330006, China – sequence: 7 givenname: Jian surname: HUANG fullname: HUANG, Jian organization: Medical Experimental Teaching Center, Nanchang University, Nanchang 330006, China – sequence: 8 givenname: Yue-Hui surname: ZHENG fullname: ZHENG, Yue-Hui email: yuehuizheng@163.com organization: Shenzhen Traditional Chinese Medicine Hospital, Shenzhen 518000, China |
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Keywords | Sestrin2-nrf2 Aging Ovarian function Chitooligosaccharide-zinc Premature ovarian failure |
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Snippet | Chitooligosaccharide-zinc (COS·Zn) is a powerful anti-oxidant and anti-aging scavenger, whose anti-oxidative ability immensely exceeds vitamin C. Therefore,... |
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SubjectTerms | Aging Chitooligosaccharide-zinc Ovarian function Premature ovarian failure Sestrin2-nrf2 |
Title | Effects of chitooligosaccharide-zinc on the ovarian function of mice with premature ovarian failure via the SESN2/NRF2 signaling pathway |
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