TFEB safeguards trophoblast syncytialization in humans and mice

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 121; no. 28; p. e2404062121
• Main Authors: Zheng, Wanshan, Zhang, Yue, Xu, Peiqun, Wang, Zexin, Shao, Xuan, Chen, Chunyan, Cai, Han, Wang, Yinan, Sun, Ming-an, Deng, Wenbo, Liu, Fan, Lu, Jinhua, Zhang, Xueqin, Cheng, Dunjin, Mysorekar, Indira U., Wang, Haibin, Wang, Yan-Ling, Hu, Xiaoqian, Cao, Bin
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 09.07.2024
• Subjects: Animals; Autophagy - physiology; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism; Biological Sciences; Cell Differentiation; Female; Humans; Mechanistic Target of Rapamycin Complex 1 - metabolism; Mice; Placenta - metabolism; Pregnancy; Signal Transduction; Trophoblasts - metabolism; TFEB; ERVFRD-1; fetal growth restriction; human trophoblast stem cell; syncytiotrophoblast

Nutrient sensing and adaptation in the placenta are essential for pregnancy viability and proper fetal growth. Our recent study demonstrated that the placenta adapts to nutrient insufficiency through mechanistic target of rapamycin (mTOR) inhibition–mediated trophoblast differentiation toward syncyt...