The Expression of Interleukin-22 and S100A7, A8, A9 mRNA in Patients with Psoriasis Vulgaris

• Published in: Journal of Huazhong University of Science and Technology. Medical sciences Vol. 27; no. 5; pp. 605 - 607
• Main Author: 刘厚君 黄琨 吴艳 林能兴 李家文 涂亚庭
• Format: Journal Article
• Language: English
• Published: China Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China 01.10.2007
• Subjects: Adolescent; Adult; Aged; Calgranulin A - genetics; Calgranulin A - metabolism; Calgranulin B - genetics; Calgranulin B - metabolism; Female; Humans; Interleukin-22; Interleukins - genetics; Interleukins - metabolism; Male; Middle Aged; Psoriasis - metabolism; Psoriasis - pathology; RNA, Messenger - genetics; RNA, Messenger - metabolism; S100 Calcium Binding Protein A7; S100 Proteins - genetics; S100 Proteins - metabolism; Skin - metabolism; Young Adult; 内白细胞素-22; 基因表达; 牛皮癣; 皮肤病; psoriasis vulgaris; interleukin-22; S100A9; S100A8; S100A7
• ISSN: 1672-0733; 1993-1352
• DOI: 10.1007/s11596-007-0533-z

In order to study the expression of interleukin-22 （IL-22） and S 100A7, A8, A9 mRNA in the skin lesions of patients with psoriasis vulgaris and their relationship, the biopsies were taken from skin lesions in 35 patients with psoriasis vulgaris and the skin of 16 normal controls, and the expression levels of 1L-22 and S 100A7, A8 and A9 mRNA were detected by semi-quantitative RT-PCR. The results showed that （1） IL-22 and S 100A8, A9 mRNA were positively expressed in the psoriatic skin lesions but negatively expressed in the normal controls; The expression level of S 100A7 was （1.133±0.040） in the psoriatic skin lesions, significantly higher than that in the normal controls （0.744±0.037, P〈0.01）. （2） There were significantly positive correlations between the expression of IL-22/S100A7 mRNA, IL-22/S100A8 mRNA, IL-22/S100A9 mRNA in the psoriasis vulgaris （r1=-0.543, r2=0.774, r3=0.621, P〈0.01）. It was concluded that IL-22 and S 100A7, A8, A9 might play important roles in the occurrence and progression of psoriasis.