Brazilian propolis-derived components inhibit TNF-α-mediated downregulation of adiponectin expression via different mechanisms in 3T3-L1 adipocytes
Previous reports suggest that Brazilian propolis has multiple biological functions and may help to restore adiponectin expression and insulin sensitivity. However, little is known about the molecular mechanisms by which these compounds inhibit the downregulation of adiponectin. The effect of various...
Saved in:
| Published in | Biochimica et biophysica acta Vol. 1810; no. 7; pp. 695 - 703 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier B.V
01.07.2011
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Previous reports suggest that Brazilian propolis has multiple biological functions and may help to restore adiponectin expression and insulin sensitivity. However, little is known about the molecular mechanisms by which these compounds inhibit the downregulation of adiponectin.
The effect of various Brazilian propolis-derived components on inhibition of tumor necrosis factor-α (TNF-α)-mediated downregulation of adiponectin expression in 3T3-L1 adipocytes and molecular mechanism was investigated.
Pretreatment with either artepillin C (C3) or its derivative (C4) significantly inhibited TNF-α-mediated downregulation of adiponectin expression in 3T3-L1 adipocytes. Interestingly, C3 strongly activated peroxisome proliferator-activated receptor γ (PPARγ) transcriptional activity. Treatment of adipocytes with C3 resulted in the upregulation of adiponectin and fatty acid-binding protein 4 expression, but C4 did not significantly induce PPARγ transactivation. C4 did, however, inhibit the TNF-α-induced c-Jun-NH2-terminal kinase (JNK) signaling that is involved in adiponectin expression. Molecular docking studies based on hPPARγ with C3 and JNK1 with C4 clearly supported our experimental results. These data demonstrate that 1) both C3 and C4 significantly inhibit the TNF-α-mediated downregulation of adiponectin in adipocytes, 2) C3 functions as a PPARγ agonist, and its inhibition of the effect of TNF-α is due to this PPARγ transactivation, and 3) C4 is an effective inhibitor of JNK activation, thus inhibiting the TNF-α-mediated downregulation of adiponectin.
Brazilian propolis-derived components (C3 and C4) can significantly inhibit TNF-α-mediated downregulation of adiponectin in adipocytes, although they do so via different mechanisms.
[Display omitted]
► Two types of propolis components inhibit downregulation of adiponectin via different mechanisms. ► Artepillin C (C3) functions as a PPARγ agonist. ► C3 can form a stable complex with the hPPARγ LBD based on molecular docking studies. ► C4 is an effective inhibitor of JNK activation. The predicted binding mode of C4 was similar to the binding modes of known JNK inhibitors. |
|---|---|
| AbstractList | Previous reports suggest that Brazilian propolis has multiple biological functions and may help to restore adiponectin expression and insulin sensitivity. However, little is known about the molecular mechanisms by which these compounds inhibit the downregulation of adiponectin.
The effect of various Brazilian propolis-derived components on inhibition of tumor necrosis factor-α (TNF-α)-mediated downregulation of adiponectin expression in 3T3-L1 adipocytes and molecular mechanism was investigated.
Pretreatment with either artepillin C (C3) or its derivative (C4) significantly inhibited TNF-α-mediated downregulation of adiponectin expression in 3T3-L1 adipocytes. Interestingly, C3 strongly activated peroxisome proliferator-activated receptor γ (PPARγ) transcriptional activity. Treatment of adipocytes with C3 resulted in the upregulation of adiponectin and fatty acid-binding protein 4 expression, but C4 did not significantly induce PPARγ transactivation. C4 did, however, inhibit the TNF-α-induced c-Jun-NH(2)-terminal kinase (JNK) signaling that is involved in adiponectin expression. Molecular docking studies based on hPPARγ with C3 and JNK1 with C4 clearly supported our experimental results. These data demonstrate that 1) both C3 and C4 significantly inhibit the TNF-α-mediated downregulation of adiponectin in adipocytes, 2) C3 functions as a PPARγ agonist, and its inhibition of the effect of TNF-α is due to this PPARγ transactivation, and 3) C4 is an effective inhibitor of JNK activation, thus inhibiting the TNF-α-mediated downregulation of adiponectin.
Brazilian propolis-derived components (C3 and C4) can significantly inhibit TNF-α-mediated downregulation of adiponectin in adipocytes, although they do so via different mechanisms. BACKGROUND: Previous reports suggest that Brazilian propolis has multiple biological functions and may help to restore adiponectin expression and insulin sensitivity. However, little is known about the molecular mechanisms by which these compounds inhibit the downregulation of adiponectin. METHODS: The effect of various Brazilian propolis-derived components on inhibition of tumor necrosis factor-α (TNF-α)-mediated downregulation of adiponectin expression in 3T3-L1 adipocytes and molecular mechanism was investigated. RESULTS AND CONCLUSIONS: Pretreatment with either artepillin C (C3) or its derivative (C4) significantly inhibited TNF-α-mediated downregulation of adiponectin expression in 3T3-L1 adipocytes. Interestingly, C3 strongly activated peroxisome proliferator-activated receptor γ (PPARγ) transcriptional activity. Treatment of adipocytes with C3 resulted in the upregulation of adiponectin and fatty acid-binding protein 4 expression, but C4 did not significantly induce PPARγ transactivation. C4 did, however, inhibit the TNF-α-induced c-Jun-NH₂-terminal kinase (JNK) signaling that is involved in adiponectin expression. Molecular docking studies based on hPPARγ with C3 and JNK1 with C4 clearly supported our experimental results. These data demonstrate that 1) both C3 and C4 significantly inhibit the TNF-α-mediated downregulation of adiponectin in adipocytes, 2) C3 functions as a PPARγ agonist, and its inhibition of the effect of TNF-α is due to this PPARγ transactivation, and 3) C4 is an effective inhibitor of JNK activation, thus inhibiting the TNF-α-mediated downregulation of adiponectin. GENERAL SIGNIFICANCE: Brazilian propolis-derived components (C3 and C4) can significantly inhibit TNF-α-mediated downregulation of adiponectin in adipocytes, although they do so via different mechanisms. Previous reports suggest that Brazilian propolis has multiple biological functions and may help to restore adiponectin expression and insulin sensitivity. However, little is known about the molecular mechanisms by which these compounds inhibit the downregulation of adiponectin. The effect of various Brazilian propolis-derived components on inhibition of tumor necrosis factor-α (TNF-α)-mediated downregulation of adiponectin expression in 3T3-L1 adipocytes and molecular mechanism was investigated. Pretreatment with either artepillin C (C3) or its derivative (C4) significantly inhibited TNF-α-mediated downregulation of adiponectin expression in 3T3-L1 adipocytes. Interestingly, C3 strongly activated peroxisome proliferator-activated receptor γ (PPARγ) transcriptional activity. Treatment of adipocytes with C3 resulted in the upregulation of adiponectin and fatty acid-binding protein 4 expression, but C4 did not significantly induce PPARγ transactivation. C4 did, however, inhibit the TNF-α-induced c-Jun-NH2-terminal kinase (JNK) signaling that is involved in adiponectin expression. Molecular docking studies based on hPPARγ with C3 and JNK1 with C4 clearly supported our experimental results. These data demonstrate that 1) both C3 and C4 significantly inhibit the TNF-α-mediated downregulation of adiponectin in adipocytes, 2) C3 functions as a PPARγ agonist, and its inhibition of the effect of TNF-α is due to this PPARγ transactivation, and 3) C4 is an effective inhibitor of JNK activation, thus inhibiting the TNF-α-mediated downregulation of adiponectin. Brazilian propolis-derived components (C3 and C4) can significantly inhibit TNF-α-mediated downregulation of adiponectin in adipocytes, although they do so via different mechanisms. [Display omitted] ► Two types of propolis components inhibit downregulation of adiponectin via different mechanisms. ► Artepillin C (C3) functions as a PPARγ agonist. ► C3 can form a stable complex with the hPPARγ LBD based on molecular docking studies. ► C4 is an effective inhibitor of JNK activation. The predicted binding mode of C4 was similar to the binding modes of known JNK inhibitors. Previous reports suggest that Brazilian propolis has multiple biological functions and may help to restore adiponectin expression and insulin sensitivity. However, little is known about the molecular mechanisms by which these compounds inhibit the downregulation of adiponectin.BACKGROUNDPrevious reports suggest that Brazilian propolis has multiple biological functions and may help to restore adiponectin expression and insulin sensitivity. However, little is known about the molecular mechanisms by which these compounds inhibit the downregulation of adiponectin.The effect of various Brazilian propolis-derived components on inhibition of tumor necrosis factor-α (TNF-α)-mediated downregulation of adiponectin expression in 3T3-L1 adipocytes and molecular mechanism was investigated.METHODSThe effect of various Brazilian propolis-derived components on inhibition of tumor necrosis factor-α (TNF-α)-mediated downregulation of adiponectin expression in 3T3-L1 adipocytes and molecular mechanism was investigated.Pretreatment with either artepillin C (C3) or its derivative (C4) significantly inhibited TNF-α-mediated downregulation of adiponectin expression in 3T3-L1 adipocytes. Interestingly, C3 strongly activated peroxisome proliferator-activated receptor γ (PPARγ) transcriptional activity. Treatment of adipocytes with C3 resulted in the upregulation of adiponectin and fatty acid-binding protein 4 expression, but C4 did not significantly induce PPARγ transactivation. C4 did, however, inhibit the TNF-α-induced c-Jun-NH(2)-terminal kinase (JNK) signaling that is involved in adiponectin expression. Molecular docking studies based on hPPARγ with C3 and JNK1 with C4 clearly supported our experimental results. These data demonstrate that 1) both C3 and C4 significantly inhibit the TNF-α-mediated downregulation of adiponectin in adipocytes, 2) C3 functions as a PPARγ agonist, and its inhibition of the effect of TNF-α is due to this PPARγ transactivation, and 3) C4 is an effective inhibitor of JNK activation, thus inhibiting the TNF-α-mediated downregulation of adiponectin.RESULTS AND CONCLUSIONSPretreatment with either artepillin C (C3) or its derivative (C4) significantly inhibited TNF-α-mediated downregulation of adiponectin expression in 3T3-L1 adipocytes. Interestingly, C3 strongly activated peroxisome proliferator-activated receptor γ (PPARγ) transcriptional activity. Treatment of adipocytes with C3 resulted in the upregulation of adiponectin and fatty acid-binding protein 4 expression, but C4 did not significantly induce PPARγ transactivation. C4 did, however, inhibit the TNF-α-induced c-Jun-NH(2)-terminal kinase (JNK) signaling that is involved in adiponectin expression. Molecular docking studies based on hPPARγ with C3 and JNK1 with C4 clearly supported our experimental results. These data demonstrate that 1) both C3 and C4 significantly inhibit the TNF-α-mediated downregulation of adiponectin in adipocytes, 2) C3 functions as a PPARγ agonist, and its inhibition of the effect of TNF-α is due to this PPARγ transactivation, and 3) C4 is an effective inhibitor of JNK activation, thus inhibiting the TNF-α-mediated downregulation of adiponectin.Brazilian propolis-derived components (C3 and C4) can significantly inhibit TNF-α-mediated downregulation of adiponectin in adipocytes, although they do so via different mechanisms.GENERAL SIGNIFICANCEBrazilian propolis-derived components (C3 and C4) can significantly inhibit TNF-α-mediated downregulation of adiponectin in adipocytes, although they do so via different mechanisms. |
| Author | Kawada, Teruo Ikeda, Rie Hirono, Shuichi Kumazawa, Shigenori Nakagome, Izumi Yamaotsu, Noriyuki Yanagisawa, Masayoshi Tsuda, Takanori Takahashi, Nobuyuki |
| Author_xml | – sequence: 1 givenname: Rie surname: Ikeda fullname: Ikeda, Rie organization: College of Bioscience and Biotechnology, Chubu University, Kasugai, Aichi 487-8501, Japan – sequence: 2 givenname: Masayoshi surname: Yanagisawa fullname: Yanagisawa, Masayoshi organization: College of Bioscience and Biotechnology, Chubu University, Kasugai, Aichi 487-8501, Japan – sequence: 3 givenname: Nobuyuki surname: Takahashi fullname: Takahashi, Nobuyuki organization: Graduate School of Agriculture, Kyoto University, Kyoto 610-0011, Japan – sequence: 4 givenname: Teruo surname: Kawada fullname: Kawada, Teruo organization: Graduate School of Agriculture, Kyoto University, Kyoto 610-0011, Japan – sequence: 5 givenname: Shigenori surname: Kumazawa fullname: Kumazawa, Shigenori organization: School of Food and Nutritional Sciences, University of Shizuoka, Shizuoka 112-8610, Japan – sequence: 6 givenname: Noriyuki surname: Yamaotsu fullname: Yamaotsu, Noriyuki organization: School of Pharmacy, Kitasato University, Tokyo 108-8641, Japan – sequence: 7 givenname: Izumi surname: Nakagome fullname: Nakagome, Izumi organization: School of Pharmacy, Kitasato University, Tokyo 108-8641, Japan – sequence: 8 givenname: Shuichi surname: Hirono fullname: Hirono, Shuichi organization: School of Pharmacy, Kitasato University, Tokyo 108-8641, Japan – sequence: 9 givenname: Takanori surname: Tsuda fullname: Tsuda, Takanori email: tsudat@isc.chubu.ac.jp organization: College of Bioscience and Biotechnology, Chubu University, Kasugai, Aichi 487-8501, Japan |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/21554928$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkUFu1DAYhS1URKeFGyDkHWwSbMdxHBZIUFFAGsFmWFuO86f9R4kT7MxAOQcX4SKcCYcUFixKNl7ke8_y-87IiR89EPKYs5wzrp7v86axV-BzwTjPmcwZq-6RDdeVyDRj6oRsWMFkJrkqT8lZjHuWvrIuH5BTwctS1kJvyPfXwX7DHq2nUxinsceYtRDwCC114zClO_0cKfprbHCmuw-X2c8f2QAt2jkh7fjFB7g69HbG0dOxo7bFJeRm9BS-TgFiXP4c0dIWuw5C6qMDuGvrMQ5LMy12Rbbla9LdzBAfkvud7SM8uj3PyafLN7uLd9n249v3F6-2mStqOWcWKgWya7QuqsYyq2XBRSEk11qVqq7aWjnV2q4oreOiaoCDtgygLZXQqmmKc_J07U1P_3yAOJsBo4O-tx7GQzRa1aUWoq4T-exOUizb8rJmMqFPbtFDk3YyU8DBhhvzZ_MEyBVwYYwxQPcX4cwsas3erGrNotYwaZLaFHvxT8zh_Hv2OVjs_xd-uYYhzXlECCY6BO-Sx5BcmXbEuwt-AVepxDY |
| CitedBy_id | crossref_primary_10_1371_journal_pone_0172909 crossref_primary_10_1007_s43450_020_00122_5 crossref_primary_10_4327_jsnfs_75_275 crossref_primary_10_1016_j_ejbas_2015_06_003 crossref_primary_10_2220_biomedres_36_343 crossref_primary_10_3390_ijms22136954 crossref_primary_10_1186_s13020_022_00651_2 crossref_primary_10_3389_fendo_2021_727061 crossref_primary_10_1016_j_jff_2020_104135 crossref_primary_10_1021_acs_jafc_1c06194 crossref_primary_10_1016_j_bbagen_2014_06_011 crossref_primary_10_1007_s13668_024_00524_0 crossref_primary_10_1039_C4FO00032C crossref_primary_10_3390_antiox10030348 crossref_primary_10_3389_fnut_2023_1066789 crossref_primary_10_1371_journal_pone_0162512 crossref_primary_10_4327_jsnfs_77_157 crossref_primary_10_3390_molecules24234394 crossref_primary_10_3390_chemistry3020045 crossref_primary_10_1016_j_foodres_2017_08_066 crossref_primary_10_1039_D3FO03287F crossref_primary_10_3390_pharmaceutics13111763 crossref_primary_10_1007_s00436_015_4890_4 crossref_primary_10_1371_journal_pone_0145954 crossref_primary_10_1016_j_bmc_2013_10_044 crossref_primary_10_1021_acs_jafc_9b04835 crossref_primary_10_1002_ajoc_202100262 crossref_primary_10_1002_ptr_6875 crossref_primary_10_1016_j_fitote_2020_104775 crossref_primary_10_1093_bbb_zbae162 crossref_primary_10_3390_nu15020364 crossref_primary_10_1016_j_ctcp_2023_101732 |
| Cites_doi | 10.2337/diabetes.52.7.1655 10.1210/jc.2003-031163 10.1016/S0378-8741(99)00189-0 10.1002/mnfr.200800021 10.1038/sj.emboj.7600212 10.1172/JCI200319451 10.1248/cpb.47.1388 10.1007/BF02540666 10.1016/j.bbrc.2008.06.046 10.1021/jm060465l 10.1016/j.phymed.2004.06.015 10.1248/cpb.46.1477 10.1161/CIRCULATIONAHA.104.475673 10.1021/ja00124a002 10.1002/jcc.1032 10.1021/jm0306430 10.1021/jf048726s 10.1161/01.ATV.0000183883.72263.13 10.1021/ci050283k 10.1021/je60033a020 10.1016/j.bbrc.2004.12.026 10.1016/S0378-8741(03)00042-4 10.1172/JCI200319246 10.1016/j.ejphar.2008.02.067 10.1021/ci700041j 10.1016/j.bmc.2009.11.007 10.1055/s-2006-947185 10.2337/diabetes.50.9.2094 10.1126/science.7678183 10.1016/S0378-8741(01)00404-4 10.1016/0040-4020(80)80168-2 10.1038/nature01137 10.1248/cpb.51.740 10.1073/pnas.251194298 10.1016/j.bmc.2010.06.093 10.1023/A:1007996124545 10.1038/227680a0 10.1016/j.bmcl.2008.11.077 10.1016/S0308-8146(03)00216-4 10.1002/ptr.2797 10.1038/90984 10.1248/bpb.28.1928 10.1074/jbc.M105061200 10.1016/j.abb.2004.02.021 10.1016/S0014-5793(02)02390-6 10.1038/nm1111 10.1152/ajpendo.00227.2002 10.1074/jbc.M411076200 10.1161/01.ATV.0000251608.09329.9a 10.1051/apido:2000102 10.1021/jf051962y |
| ContentType | Journal Article |
| Copyright | 2011 Elsevier B.V. 2011 Elsevier B.V. All rights reserved. |
| Copyright_xml | – notice: 2011 Elsevier B.V. – notice: 2011 Elsevier B.V. All rights reserved. |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7S9 L.6 7X8 |
| DOI | 10.1016/j.bbagen.2011.04.007 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed AGRICOLA AGRICOLA - Academic MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) AGRICOLA AGRICOLA - Academic MEDLINE - Academic |
| DatabaseTitleList | MEDLINE AGRICOLA MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Chemistry Biology |
| EISSN | 1872-8006 |
| EndPage | 703 |
| ExternalDocumentID | 21554928 10_1016_j_bbagen_2011_04_007 S0304416511000845 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | --- --K --M .~1 0R~ 1B1 1RT 1~. 1~5 23N 3O- 4.4 457 4G. 53G 5GY 5RE 5VS 7-5 71M 8P~ 9JM AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AAXUO ABEFU ABFNM ABGSF ABMAC ABUDA ABXDB ABYKQ ACDAQ ACIUM ACRLP ADBBV ADEZE ADMUD ADUVX AEBSH AEHWI AEKER AFKWA AFTJW AFXIZ AGHFR AGRDE AGUBO AGYEJ AHHHB AIEXJ AIKHN AITUG AJBFU AJOXV ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC CS3 DOVZS EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HLW HVGLF HZ~ IHE J1W KOM LX3 M41 MO0 N9A O-L O9- OAUVE OHT OZT P-8 P-9 PC. Q38 R2- ROL RPZ SBG SCC SDF SDG SDP SES SEW SPCBC SSU SSZ T5K UQL WH7 WUQ XJT XPP ~G- AAHBH AATTM AAXKI AAYWO AAYXX ABWVN ACRPL ACVFH ADCNI ADNMO AEIPS AEUPX AFJKZ AFPUW AGCQF AGQPQ AGRNS AIGII AIIUN AKBMS AKRWK AKYEP ANKPU APXCP BNPGV CITATION SSH -~X .55 .GJ AAYJJ ABJNI AFFNX AI. CGR CUY CVF ECM EIF F5P H~9 K-O MVM NPM RIG TWZ UHS VH1 X7M Y6R YYP ZE2 ZGI ~KM 7S9 L.6 7X8 |
| ID | FETCH-LOGICAL-c394t-ae76e4fb8837ba0a8431232418865697d96c6daf35ac127be1e8a0eed56286bb3 |
| IEDL.DBID | .~1 |
| ISSN | 0304-4165 0006-3002 |
| IngestDate | Fri Jul 11 05:52:35 EDT 2025 Fri Jul 11 07:46:28 EDT 2025 Mon Jul 21 05:54:28 EDT 2025 Thu Apr 24 23:06:36 EDT 2025 Tue Jul 01 00:21:58 EDT 2025 Fri Feb 23 02:32:41 EST 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 7 |
| Keywords | Adipocyte aP2 EMM JNK Propolis vdW MM-PBSA MAPK MKK Adiponectin SEK1/MKK4 PPAR TNF-α Peroxisome proliferator-activated receptor FBS TTBS c-Jun-NH2-terminal kinase TZD |
| Language | English |
| License | https://www.elsevier.com/tdm/userlicense/1.0 2011 Elsevier B.V. All rights reserved. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c394t-ae76e4fb8837ba0a8431232418865697d96c6daf35ac127be1e8a0eed56286bb3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| PMID | 21554928 |
| PQID | 2000015904 |
| PQPubID | 24069 |
| PageCount | 9 |
| ParticipantIDs | proquest_miscellaneous_869582299 proquest_miscellaneous_2000015904 pubmed_primary_21554928 crossref_primary_10_1016_j_bbagen_2011_04_007 crossref_citationtrail_10_1016_j_bbagen_2011_04_007 elsevier_sciencedirect_doi_10_1016_j_bbagen_2011_04_007 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | July 2011 2011-07-00 2011-Jul 20110701 |
| PublicationDateYYYYMMDD | 2011-07-01 |
| PublicationDate_xml | – month: 07 year: 2011 text: July 2011 |
| PublicationDecade | 2010 |
| PublicationPlace | Netherlands |
| PublicationPlace_xml | – name: Netherlands |
| PublicationTitle | Biochimica et biophysica acta |
| PublicationTitleAlternate | Biochim Biophys Acta |
| PublicationYear | 2011 |
| Publisher | Elsevier B.V |
| Publisher_xml | – name: Elsevier B.V |
| References | Nakajima, Shimazawa, Mishima, Hara (bb0120) 2009; 23 Kumazawa, Hamasaka, Nakayama (bb0065) 2004; 84 Ahn, Kunimasa, Kumazawa, Nakayama, Kaji, Uto, Hori, Nagasawa, Ohta (bb0125) 2009; 53 Oda, Tsuchida, Takakura, Yamaotsu, Hirono (bb0160) 2006; 46 Laemmuli (bb0150) 1970; 227 Tazawa, Warashina, Noro, Miyase (bb0105) 1998; 46 Kim, Kim, Jeon, Yoon, Choi, Yang (bb0220) 2005; 327 Friesner, Banks, Murphy, Halgren, Klicic, Mainz (bb0165) 2004; 47 Ahn, Kumazawa, Hamasaka, Bang, Nakayama (bb0070) 2004; 52 Bonvehí, Coll, Jorda (bb0050) 1994; 71 Cornell, Cieplak, Bayly, Gould, Merz, Ferguson, Spellmeyer, Fox, Caldwell, Kollman (bb0175) 1995; 117 Purcell, Singer (bb0190) 1967; 12 Mahadev, Wu, Zilbering, Zhu, Lawrence, Goldstein (bb0145) 2001; 276 Kumazawa, Yoneda, Shibata, Kaneda, Hamazaka, Nakayama (bb0115) 2003; 51 Hotamisligil, Shargill, Spiegelman (bb0030) 1993; 259 Brown, Plutzky (bb0045) 2007; 115 Oršolic, Terzic, Mihaljevic, Šver, Bašic (bb0095) 2005; 28 Murad, Calvi, Soares, Bankova, Sforcin (bb0100) 2002; 79 Amoros, Lurton, Boustie, Girre, Sauvager, Cormier (bb0080) 1994; 64 Weisberg, McCann, Desai, Rosenbaum, Leibel, Ferrante (bb0020) 2003; 112 Suganami, Nishida, Ogawa (bb0035) 2005; 25 Xu, Barnes, Yang, Tan, Yang, Chou, Sole, Nichols, Ross, Tartaglia, Chen (bb0025) 2003; 112 Heo, Kim, Seo, Kim, Sung, Lee, Lee, Park, Kim, Hwang, Hyun, Jeon, Ro, Cho, Lee, Yang (bb0250) 2004; 23 Eldridge, Murray, Auton, Paolini, Mee (bb0170) 1997; 11 Paulino, Abreu, Uto, Koyama, Nagasawa, Hori, Dirsch, Vollmar, Scremin, Bretz (bb0225) 2008; 587 Chamberlain, Redman, Wilson, Deanda, Shotwell, Gerding, Lei, Yang, Stevens, Hassell, Shewchuk, Leesnitzer, Smith, Sabbatini, Atkins, Groy, Rowand, Kumar, Mook, Moorthy, Patnaik (bb0255) 2009; 19 Tazawa, Warashina, Noro (bb0110) 1999; 47 Bankova, Castro, Marcucci (bb0055) 2000; 31 Gouda, Sunazuka, Hirose, Iguchi, Yamaotsu, Sugawara, Noguchi, Saito, Yamamoto, Watanabe, Shiomi, Ōmura, Hirono (bb0195) 2010; 18 Brown, Muchmore (bb0200) 2007; 47 Yamamoto, Hirose, Saito, Nishikai, Saruta (bb0010) 2004; 89 Makimura, Mizuno, Bergen, Mobbs (bb0005) 2002; 283 Maeda, Takahashi, Funahashi, Kihara, Nishizawa, Kishida, Nagaretani, Matsuda, Komuro, Ouchi, Kuriyama, Hotta, Nakamura, Shimomura, Matsuzawa (bb0210) 2001; 50 Kartal, Yildiz, Kaya, Kurucu, Topcu (bb0075) 2003; 86 Ozkul, Silici, Eroğlu (bb0090) 2005; 2 Yamauchi, Waki, Terauchi, Kubota, Hara, Mori, Ide, Murakami, Tsuboyama-Kasaoka, Ezaki, Akanuma, Gavrilova, Vinson, Reitman, Kagechika, Shudo, Yoda, Nakano, Tobe, Nagai, Kimura, Tomita, Froguel, Kadowaki (bb0015) 2001; 7 Suganami, Tanimoto-Koyama, Nishida, Itoh, Yuan, Mizuarai, Kotani, Yamaoka, Miyake, Aoe, Kamei, Ogawa (bb0040) 2007; 27 Isa, Miyakawa, Yanagisawa, Goto, Kang, Kawada, Morimitsu, Kubota, Tsuda (bb0135) 2008; 373 Bennett, Sasaki, Murray, O'Leary, Sakata, Xu, Leisten, Motiwala, Pierce, Satoh, Bhagwat, Manning, Anderson (bb0245) 2001; 98 Katsuki, Chuang, Nishi, Kawahara, Nakayama, Yamaotsu, Hirono, Otagiri (bb0155) 2005; 280 Gasteiger, Marsili (bb0180) 1980; 36 Iwaki, Matsuda, Maeda, Funahashi, Matsuzawa, Makishima, Shimomura (bb0215) 2003; 52 Grant, Pickup, Nicholls (bb0205) 2001; 22 Takahashi, Kawada, Goto, Yamanoto, Taimatsu, Matsui, Kimura, Saito, Hosokawa, Miyashita, Fushiki (bb0140) 2002; 514 Nieva Moreno, Isla, Sampieto, Vattuone (bb0060) 2000; 71 Hirosumi, Tuncman, Chang, Görgün, Uysal, Maeda, Karin, Hotamisligil (bb0230) 2002; 420 Kaneto, Nakatani, Miyatsuka, Kawamori, Matsuoka, Matsuhisa, Kajimoto, Ichijo, Yamasaki, Hori (bb0235) 2004; 10 Shimizu, Ashida, Matsuura, Kanazawa (bb0260) 2004; 424 Tani, Hasumi, Tatefuji, Hashimoto, Koshino, Takahashi (bb0130) 2010; 18 Konishi, Hitomi, Yoshida, Yoshioka (bb0265) 2005; 53 Zhao, Serby, Xin, Szczepankiewicz, Liu, Kosogof, Liu, Nelson, Johnson, Wang, Pederson, Gum, Clampit, Haasch, Abad-Zapatero, Fry, Rondinone, Trevillyan, Sham, Liu (bb0240) 2006; 49 Gasteiger, Marsili (bb0185) 1981; 15 Paulino, Teixeira, Martins, Scremin, Dirsch, Vollmar, Abreu, de Castro, Marcucci (bb0085) 2006; 79 Oda (10.1016/j.bbagen.2011.04.007_bb0160) 2006; 46 Oršolic (10.1016/j.bbagen.2011.04.007_bb0095) 2005; 28 Laemmuli (10.1016/j.bbagen.2011.04.007_bb0150) 1970; 227 Hirosumi (10.1016/j.bbagen.2011.04.007_bb0230) 2002; 420 Kumazawa (10.1016/j.bbagen.2011.04.007_bb0065) 2004; 84 Hotamisligil (10.1016/j.bbagen.2011.04.007_bb0030) 1993; 259 Cornell (10.1016/j.bbagen.2011.04.007_bb0175) 1995; 117 Murad (10.1016/j.bbagen.2011.04.007_bb0100) 2002; 79 Ahn (10.1016/j.bbagen.2011.04.007_bb0125) 2009; 53 Gasteiger (10.1016/j.bbagen.2011.04.007_bb0185) 1981; 15 Paulino (10.1016/j.bbagen.2011.04.007_bb0085) 2006; 79 Chamberlain (10.1016/j.bbagen.2011.04.007_bb0255) 2009; 19 Shimizu (10.1016/j.bbagen.2011.04.007_bb0260) 2004; 424 Purcell (10.1016/j.bbagen.2011.04.007_bb0190) 1967; 12 Grant (10.1016/j.bbagen.2011.04.007_bb0205) 2001; 22 Kim (10.1016/j.bbagen.2011.04.007_bb0220) 2005; 327 Nakajima (10.1016/j.bbagen.2011.04.007_bb0120) 2009; 23 Tani (10.1016/j.bbagen.2011.04.007_bb0130) 2010; 18 Konishi (10.1016/j.bbagen.2011.04.007_bb0265) 2005; 53 Kartal (10.1016/j.bbagen.2011.04.007_bb0075) 2003; 86 Makimura (10.1016/j.bbagen.2011.04.007_bb0005) 2002; 283 Bennett (10.1016/j.bbagen.2011.04.007_bb0245) 2001; 98 Mahadev (10.1016/j.bbagen.2011.04.007_bb0145) 2001; 276 Gouda (10.1016/j.bbagen.2011.04.007_bb0195) 2010; 18 Friesner (10.1016/j.bbagen.2011.04.007_bb0165) 2004; 47 Bonvehí (10.1016/j.bbagen.2011.04.007_bb0050) 1994; 71 Weisberg (10.1016/j.bbagen.2011.04.007_bb0020) 2003; 112 Kumazawa (10.1016/j.bbagen.2011.04.007_bb0115) 2003; 51 Kaneto (10.1016/j.bbagen.2011.04.007_bb0235) 2004; 10 Brown (10.1016/j.bbagen.2011.04.007_bb0045) 2007; 115 Eldridge (10.1016/j.bbagen.2011.04.007_bb0170) 1997; 11 Tazawa (10.1016/j.bbagen.2011.04.007_bb0110) 1999; 47 Paulino (10.1016/j.bbagen.2011.04.007_bb0225) 2008; 587 Nieva Moreno (10.1016/j.bbagen.2011.04.007_bb0060) 2000; 71 Yamauchi (10.1016/j.bbagen.2011.04.007_bb0015) 2001; 7 Iwaki (10.1016/j.bbagen.2011.04.007_bb0215) 2003; 52 Yamamoto (10.1016/j.bbagen.2011.04.007_bb0010) 2004; 89 Ahn (10.1016/j.bbagen.2011.04.007_bb0070) 2004; 52 Maeda (10.1016/j.bbagen.2011.04.007_bb0210) 2001; 50 Gasteiger (10.1016/j.bbagen.2011.04.007_bb0180) 1980; 36 Suganami (10.1016/j.bbagen.2011.04.007_bb0035) 2005; 25 Katsuki (10.1016/j.bbagen.2011.04.007_bb0155) 2005; 280 Tazawa (10.1016/j.bbagen.2011.04.007_bb0105) 1998; 46 Ozkul (10.1016/j.bbagen.2011.04.007_bb0090) 2005; 2 Takahashi (10.1016/j.bbagen.2011.04.007_bb0140) 2002; 514 Xu (10.1016/j.bbagen.2011.04.007_bb0025) 2003; 112 Bankova (10.1016/j.bbagen.2011.04.007_bb0055) 2000; 31 Amoros (10.1016/j.bbagen.2011.04.007_bb0080) 1994; 64 Heo (10.1016/j.bbagen.2011.04.007_bb0250) 2004; 23 Suganami (10.1016/j.bbagen.2011.04.007_bb0040) 2007; 27 Isa (10.1016/j.bbagen.2011.04.007_bb0135) 2008; 373 Brown (10.1016/j.bbagen.2011.04.007_bb0200) 2007; 47 Zhao (10.1016/j.bbagen.2011.04.007_bb0240) 2006; 49 |
| References_xml | – volume: 23 start-page: 1431 year: 2009 end-page: 1438 ident: bb0120 article-title: Neuroprotective effects of Brazilian green propolis and its main constituents against oxygen-glucose deprivation stress, with a gene-expression analysis publication-title: Phytother. Res. – volume: 46 start-page: 1477 year: 1998 end-page: 1479 ident: bb0105 article-title: Studies on the constituents of Brazilian propolis publication-title: Chem. Pharm. Bull. – volume: 283 start-page: 1266 year: 2002 end-page: 1271 ident: bb0005 article-title: Adiponectin is stimulated by adrenalectomy in ob/ob mice and is highly correlated with resistin mRNA publication-title: Am. J. Physiol. Endocrinol. Metab. – volume: 46 start-page: 380 year: 2006 end-page: 391 ident: bb0160 article-title: Comparison of consensus scoring strategies for evaluating computational models of protein–ligand complexes publication-title: J. Chem. Inf. Model. – volume: 23 start-page: 2185 year: 2004 end-page: 2195 ident: bb0250 article-title: Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125 publication-title: EMBO J. – volume: 31 start-page: 3 year: 2000 end-page: 15 ident: bb0055 article-title: Propolis: recent advances in chemistry and plant origin publication-title: Apidologie – volume: 7 start-page: 941 year: 2001 end-page: 946 ident: bb0015 article-title: The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity publication-title: Nat. Med. – volume: 47 start-page: 1388 year: 1999 end-page: 1392 ident: bb0110 article-title: Studies on the constituents of Brazilian propolis II publication-title: Chem. Pharm. Bull. – volume: 12 start-page: 235 year: 1967 end-page: 246 ident: bb0190 article-title: A brief review and table of semiempirical parameters used in the Hüeckel molecular orbital method publication-title: J. Chem. Eng. Data – volume: 18 start-page: 5835 year: 2010 end-page: 5844 ident: bb0195 article-title: NMR spectroscopy and computational analysis of interaction between publication-title: Bioorg. Med. Chem. – volume: 10 start-page: 1128 year: 2004 end-page: 1132 ident: bb0235 article-title: Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide publication-title: Nat. Med. – volume: 117 start-page: 5179 year: 1995 end-page: 5197 ident: bb0175 article-title: A second generation force field for the simulation of proteins, nucleic acids, and organic molecules publication-title: J. Am. Chem. Soc. – volume: 51 start-page: 740 year: 2003 end-page: 742 ident: bb0115 article-title: Direct evidence for the plant origin of Brazilian propolis by the observation of honeybee behavior and phytochemical analysis publication-title: Chem. Pharm. Bull. – volume: 280 start-page: 1384 year: 2005 end-page: 1391 ident: bb0155 article-title: Use of photoaffinity labeling and site-directed mutagenesis for identification of the key residue responsible for extraordinarily high affinity binding of UCN-01 in human α1-acid glycoprotein publication-title: J. Biol. Chem. – volume: 2 start-page: 742 year: 2005 end-page: 747 ident: bb0090 article-title: The anticarcinogenic effect of propolis in human lymphocytes culture publication-title: Phytomedicine – volume: 79 start-page: 331 year: 2002 end-page: 334 ident: bb0100 article-title: Effect of propolis from Brazil and Bulgaria in fungicidal activity of mactophages against Paracoccidioides brasiliensis publication-title: J. Ethnopharmacol. – volume: 47 start-page: 1739 year: 2004 end-page: 1749 ident: bb0165 article-title: Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy publication-title: J. Med. Chem. – volume: 28 start-page: 1928 year: 2005 end-page: 1933 ident: bb0095 article-title: Effects of local administration of propolis and its polyphenolic compounds on tumor formation and growth publication-title: Biol. Pharm. Bull. – volume: 115 start-page: 518 year: 2007 end-page: 533 ident: bb0045 article-title: Peroxisome proliferator-activated receptors as transcriptional nodal points and therapeutic targets publication-title: Circulation – volume: 587 start-page: 296 year: 2008 end-page: 301 ident: bb0225 article-title: Anti-inflammatory effects of a bioavailable compound, Artepillin C, in Brazilian propolis publication-title: Eur. J. Pharmacol. – volume: 15 start-page: 353 year: 1981 end-page: 360 ident: bb0185 article-title: Prediction of proton magnetic resonance shifts: the dependence on hydrogen charges obtained by iterative partial equalization of orbital electronegativity publication-title: Magn. Reson. Chem. – volume: 112 start-page: 1821 year: 2003 end-page: 1830 ident: bb0025 article-title: Chronic inflammation in fat plays a crucial role in the development of obesity related insulin resistance publication-title: J. Clin. Invest. – volume: 11 start-page: 425 year: 1997 end-page: 445 ident: bb0170 article-title: Empirical scoring functions: I. The development of a fast empirical scoring function to estimate the binding affinity of ligands in receptor complexes publication-title: J. Comput. Aided Mol. Des. – volume: 276 start-page: 48662 year: 2001 end-page: 48669 ident: bb0145 article-title: Hydrogen peroxide generated during cellular insulin stimulation is integral to activation of the distal insulin signaling cascade in 3T3-L1 adipcytes publication-title: J. Biol. Chem. – volume: 71 start-page: 529 year: 1994 end-page: 532 ident: bb0050 article-title: The composition, active components and bacteriostatic activity of propolis in dietetics publication-title: J. Am. Oil Chem. Soc. – volume: 79 start-page: 899 year: 2006 end-page: 906 ident: bb0085 article-title: Evaluation of the analgesic and anti-inflammatory effects of a Brazilian green propolis publication-title: Planta Med. – volume: 89 start-page: 87 year: 2004 end-page: 90 ident: bb0010 article-title: Adiponectin, an adipocyte-derived protein, predicts future insulin resistance: two-year follow-up study in Japanese population publication-title: J. Clin. Endocrinol. Metab. – volume: 25 start-page: 2062 year: 2005 end-page: 2068 ident: bb0035 article-title: A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: role of free fatty acids and tumor necrosis factor alpha publication-title: Arterioscler. Thromb. Vasc. Biol. – volume: 50 start-page: 2094 year: 2001 end-page: 2099 ident: bb0210 article-title: PPARγ ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein publication-title: Diabetes – volume: 227 start-page: 680 year: 1970 end-page: 685 ident: bb0150 article-title: Cleavage of structural proteins during the assembly of the head of bacteriophage T4 publication-title: Nature – volume: 49 start-page: 4455 year: 2006 end-page: 4458 ident: bb0240 article-title: Discovery of potent, highly selective, and orally bioavailable pyridine carboxamide c-Jun NH publication-title: J. Med. Chem. – volume: 19 start-page: 360 year: 2009 end-page: 364 ident: bb0255 article-title: Optimization of 4,6-bis-anilino-1 publication-title: Bioorg. Med. Chem. Lett. – volume: 27 start-page: 84 year: 2007 end-page: 91 ident: bb0040 article-title: Role of the toll-like receptor 4/NF-kB pathway in saturated fatty acid-induced inflammatory changes in the interaction between adipocytes and macrophages publication-title: Arterioscler. Thromb. Vasc. Biol. – volume: 52 start-page: 1655 year: 2003 end-page: 1663 ident: bb0215 article-title: Induction of adiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors publication-title: Diabetes – volume: 22 start-page: 608 year: 2001 end-page: 640 ident: bb0205 article-title: A smooth permittivity function for Poisson–Boltzmann solvation methods publication-title: J. Comput. Chem. – volume: 53 start-page: 9928 year: 2005 end-page: 9933 ident: bb0265 article-title: Absorption and bioavailability of artepillin C in rats after oral administration publication-title: J. Agric. Food Chem. – volume: 36 start-page: 3219 year: 1980 end-page: 3228 ident: bb0180 article-title: Iterative partial equalization of orbital electronegativity: a rapid access to atomic charges publication-title: Tetrahedron – volume: 71 start-page: 109 year: 2000 end-page: 114 ident: bb0060 article-title: Comparison of the free radical-scavenging activity of propolis from several regions of Argentina publication-title: J. Ethnopharmacol. – volume: 86 start-page: 69 year: 2003 end-page: 73 ident: bb0075 article-title: Antimicrobial activity of propolis samples from two different regions of Anatolia publication-title: J. Ethnopharmacol. – volume: 64 start-page: 235 year: 1994 end-page: 240 ident: bb0080 article-title: Comparison of the anti-herpes simplex virus activities of propolis and 3-methylbut-2-enyl caffeate publication-title: J. Nat. Prod. – volume: 373 start-page: 429 year: 2008 end-page: 434 ident: bb0135 article-title: 6-Shogaol and 6-gingerol, the pungent of ginger, inhibit TNF-α mediated downregulation of adiponectin expression via different mechanisms in 3T3-L1 adipocytes publication-title: Biochem. Biophys. Res. Commun. – volume: 327 start-page: 460 year: 2005 end-page: 467 ident: bb0220 article-title: c-Jun N-terminal kinase is involved in the suppression of adiponectin expression by TNF-α in 3T3-L1 adipocytes publication-title: Biochem. Biophys. Res. Commun. – volume: 53 start-page: 643 year: 2009 end-page: 651 ident: bb0125 article-title: Correlation between antiangiogenic activity and antioxidant activity of various components from propolis publication-title: Mol. Nutr. Food Res. – volume: 424 start-page: 181 year: 2004 end-page: 188 ident: bb0260 article-title: Antioxidative bioavailability of artepillin C in Brazilian propolis publication-title: Arch. Biochem. Biophys. – volume: 112 start-page: 1796 year: 2003 end-page: 1808 ident: bb0020 article-title: Obesity is associated with macrophage accumulation in adipose tissue publication-title: J. Clin. Invest. – volume: 84 start-page: 329 year: 2004 end-page: 339 ident: bb0065 article-title: Antioxidant activity of propolis of various geographic origins publication-title: Food Chem. – volume: 259 start-page: 87 year: 1993 end-page: 91 ident: bb0030 article-title: Adipose expression of tumor necrosis factor-α: direct role in obesity-linked insulin resistance publication-title: Science – volume: 52 start-page: 7286 year: 2004 end-page: 7292 ident: bb0070 article-title: Antioxidant activity and constituents of propolis collected in various areas of Korea publication-title: J. Agric. Food Chem. – volume: 18 start-page: 151 year: 2010 end-page: 157 ident: bb0130 article-title: Inhibitory activity of Brazilian green propolis components and their derivatives on the release of cys-leukotrienes publication-title: Bioorg. Med. Chem. – volume: 98 start-page: 13681 year: 2001 end-page: 13686 ident: bb0245 article-title: SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 47 start-page: 1493 year: 2007 end-page: 1503 ident: bb0200 article-title: Rapid estimation of relative protein–ligand binding affinities using a high-throughput version of MM-PBSA publication-title: J. Chem. Inf. Model. – volume: 420 start-page: 333 year: 2002 end-page: 336 ident: bb0230 article-title: A central role for JNK in obesity and insulin resistance publication-title: Nature – volume: 514 start-page: 315 year: 2002 end-page: 322 ident: bb0140 article-title: Dual action of isoprenols from herbal medicines on both PPARγ and PPARα in 3T3-L1 adipocytes and HepG2 hepatocytes publication-title: FEBS Lett. – volume: 52 start-page: 1655 year: 2003 ident: 10.1016/j.bbagen.2011.04.007_bb0215 article-title: Induction of adiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors publication-title: Diabetes doi: 10.2337/diabetes.52.7.1655 – volume: 89 start-page: 87 year: 2004 ident: 10.1016/j.bbagen.2011.04.007_bb0010 article-title: Adiponectin, an adipocyte-derived protein, predicts future insulin resistance: two-year follow-up study in Japanese population publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jc.2003-031163 – volume: 71 start-page: 109 year: 2000 ident: 10.1016/j.bbagen.2011.04.007_bb0060 article-title: Comparison of the free radical-scavenging activity of propolis from several regions of Argentina publication-title: J. Ethnopharmacol. doi: 10.1016/S0378-8741(99)00189-0 – volume: 53 start-page: 643 year: 2009 ident: 10.1016/j.bbagen.2011.04.007_bb0125 article-title: Correlation between antiangiogenic activity and antioxidant activity of various components from propolis publication-title: Mol. Nutr. Food Res. doi: 10.1002/mnfr.200800021 – volume: 23 start-page: 2185 year: 2004 ident: 10.1016/j.bbagen.2011.04.007_bb0250 article-title: Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125 publication-title: EMBO J. doi: 10.1038/sj.emboj.7600212 – volume: 112 start-page: 1821 year: 2003 ident: 10.1016/j.bbagen.2011.04.007_bb0025 article-title: Chronic inflammation in fat plays a crucial role in the development of obesity related insulin resistance publication-title: J. Clin. Invest. doi: 10.1172/JCI200319451 – volume: 47 start-page: 1388 year: 1999 ident: 10.1016/j.bbagen.2011.04.007_bb0110 article-title: Studies on the constituents of Brazilian propolis II publication-title: Chem. Pharm. Bull. doi: 10.1248/cpb.47.1388 – volume: 71 start-page: 529 year: 1994 ident: 10.1016/j.bbagen.2011.04.007_bb0050 article-title: The composition, active components and bacteriostatic activity of propolis in dietetics publication-title: J. Am. Oil Chem. Soc. doi: 10.1007/BF02540666 – volume: 373 start-page: 429 year: 2008 ident: 10.1016/j.bbagen.2011.04.007_bb0135 article-title: 6-Shogaol and 6-gingerol, the pungent of ginger, inhibit TNF-α mediated downregulation of adiponectin expression via different mechanisms in 3T3-L1 adipocytes publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2008.06.046 – volume: 49 start-page: 4455 year: 2006 ident: 10.1016/j.bbagen.2011.04.007_bb0240 article-title: Discovery of potent, highly selective, and orally bioavailable pyridine carboxamide c-Jun NH2-terminal kinase inhibitors publication-title: J. Med. Chem. doi: 10.1021/jm060465l – volume: 2 start-page: 742 year: 2005 ident: 10.1016/j.bbagen.2011.04.007_bb0090 article-title: The anticarcinogenic effect of propolis in human lymphocytes culture publication-title: Phytomedicine doi: 10.1016/j.phymed.2004.06.015 – volume: 46 start-page: 1477 year: 1998 ident: 10.1016/j.bbagen.2011.04.007_bb0105 article-title: Studies on the constituents of Brazilian propolis publication-title: Chem. Pharm. Bull. doi: 10.1248/cpb.46.1477 – volume: 115 start-page: 518 year: 2007 ident: 10.1016/j.bbagen.2011.04.007_bb0045 article-title: Peroxisome proliferator-activated receptors as transcriptional nodal points and therapeutic targets publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.104.475673 – volume: 64 start-page: 235 year: 1994 ident: 10.1016/j.bbagen.2011.04.007_bb0080 article-title: Comparison of the anti-herpes simplex virus activities of propolis and 3-methylbut-2-enyl caffeate publication-title: J. Nat. Prod. – volume: 117 start-page: 5179 year: 1995 ident: 10.1016/j.bbagen.2011.04.007_bb0175 article-title: A second generation force field for the simulation of proteins, nucleic acids, and organic molecules publication-title: J. Am. Chem. Soc. doi: 10.1021/ja00124a002 – volume: 22 start-page: 608 year: 2001 ident: 10.1016/j.bbagen.2011.04.007_bb0205 article-title: A smooth permittivity function for Poisson–Boltzmann solvation methods publication-title: J. Comput. Chem. doi: 10.1002/jcc.1032 – volume: 47 start-page: 1739 year: 2004 ident: 10.1016/j.bbagen.2011.04.007_bb0165 article-title: Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy publication-title: J. Med. Chem. doi: 10.1021/jm0306430 – volume: 52 start-page: 7286 year: 2004 ident: 10.1016/j.bbagen.2011.04.007_bb0070 article-title: Antioxidant activity and constituents of propolis collected in various areas of Korea publication-title: J. Agric. Food Chem. doi: 10.1021/jf048726s – volume: 25 start-page: 2062 year: 2005 ident: 10.1016/j.bbagen.2011.04.007_bb0035 article-title: A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: role of free fatty acids and tumor necrosis factor alpha publication-title: Arterioscler. Thromb. Vasc. Biol. doi: 10.1161/01.ATV.0000183883.72263.13 – volume: 46 start-page: 380 year: 2006 ident: 10.1016/j.bbagen.2011.04.007_bb0160 article-title: Comparison of consensus scoring strategies for evaluating computational models of protein–ligand complexes publication-title: J. Chem. Inf. Model. doi: 10.1021/ci050283k – volume: 12 start-page: 235 year: 1967 ident: 10.1016/j.bbagen.2011.04.007_bb0190 article-title: A brief review and table of semiempirical parameters used in the Hüeckel molecular orbital method publication-title: J. Chem. Eng. Data doi: 10.1021/je60033a020 – volume: 327 start-page: 460 year: 2005 ident: 10.1016/j.bbagen.2011.04.007_bb0220 article-title: c-Jun N-terminal kinase is involved in the suppression of adiponectin expression by TNF-α in 3T3-L1 adipocytes publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2004.12.026 – volume: 86 start-page: 69 year: 2003 ident: 10.1016/j.bbagen.2011.04.007_bb0075 article-title: Antimicrobial activity of propolis samples from two different regions of Anatolia publication-title: J. Ethnopharmacol. doi: 10.1016/S0378-8741(03)00042-4 – volume: 112 start-page: 1796 year: 2003 ident: 10.1016/j.bbagen.2011.04.007_bb0020 article-title: Obesity is associated with macrophage accumulation in adipose tissue publication-title: J. Clin. Invest. doi: 10.1172/JCI200319246 – volume: 587 start-page: 296 year: 2008 ident: 10.1016/j.bbagen.2011.04.007_bb0225 article-title: Anti-inflammatory effects of a bioavailable compound, Artepillin C, in Brazilian propolis publication-title: Eur. J. Pharmacol. doi: 10.1016/j.ejphar.2008.02.067 – volume: 47 start-page: 1493 year: 2007 ident: 10.1016/j.bbagen.2011.04.007_bb0200 article-title: Rapid estimation of relative protein–ligand binding affinities using a high-throughput version of MM-PBSA publication-title: J. Chem. Inf. Model. doi: 10.1021/ci700041j – volume: 18 start-page: 151 year: 2010 ident: 10.1016/j.bbagen.2011.04.007_bb0130 article-title: Inhibitory activity of Brazilian green propolis components and their derivatives on the release of cys-leukotrienes publication-title: Bioorg. Med. Chem. doi: 10.1016/j.bmc.2009.11.007 – volume: 79 start-page: 899 year: 2006 ident: 10.1016/j.bbagen.2011.04.007_bb0085 article-title: Evaluation of the analgesic and anti-inflammatory effects of a Brazilian green propolis publication-title: Planta Med. doi: 10.1055/s-2006-947185 – volume: 50 start-page: 2094 year: 2001 ident: 10.1016/j.bbagen.2011.04.007_bb0210 article-title: PPARγ ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein publication-title: Diabetes doi: 10.2337/diabetes.50.9.2094 – volume: 259 start-page: 87 year: 1993 ident: 10.1016/j.bbagen.2011.04.007_bb0030 article-title: Adipose expression of tumor necrosis factor-α: direct role in obesity-linked insulin resistance publication-title: Science doi: 10.1126/science.7678183 – volume: 79 start-page: 331 year: 2002 ident: 10.1016/j.bbagen.2011.04.007_bb0100 article-title: Effect of propolis from Brazil and Bulgaria in fungicidal activity of mactophages against Paracoccidioides brasiliensis publication-title: J. Ethnopharmacol. doi: 10.1016/S0378-8741(01)00404-4 – volume: 36 start-page: 3219 year: 1980 ident: 10.1016/j.bbagen.2011.04.007_bb0180 article-title: Iterative partial equalization of orbital electronegativity: a rapid access to atomic charges publication-title: Tetrahedron doi: 10.1016/0040-4020(80)80168-2 – volume: 420 start-page: 333 year: 2002 ident: 10.1016/j.bbagen.2011.04.007_bb0230 article-title: A central role for JNK in obesity and insulin resistance publication-title: Nature doi: 10.1038/nature01137 – volume: 51 start-page: 740 year: 2003 ident: 10.1016/j.bbagen.2011.04.007_bb0115 article-title: Direct evidence for the plant origin of Brazilian propolis by the observation of honeybee behavior and phytochemical analysis publication-title: Chem. Pharm. Bull. doi: 10.1248/cpb.51.740 – volume: 98 start-page: 13681 year: 2001 ident: 10.1016/j.bbagen.2011.04.007_bb0245 article-title: SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.251194298 – volume: 18 start-page: 5835 year: 2010 ident: 10.1016/j.bbagen.2011.04.007_bb0195 article-title: NMR spectroscopy and computational analysis of interaction between Serratia marcescens chitinase B and a dipeptide derived from natural-product cyclopentapeptide chitinase inhibitor argifin publication-title: Bioorg. Med. Chem. doi: 10.1016/j.bmc.2010.06.093 – volume: 11 start-page: 425 year: 1997 ident: 10.1016/j.bbagen.2011.04.007_bb0170 article-title: Empirical scoring functions: I. The development of a fast empirical scoring function to estimate the binding affinity of ligands in receptor complexes publication-title: J. Comput. Aided Mol. Des. doi: 10.1023/A:1007996124545 – volume: 227 start-page: 680 year: 1970 ident: 10.1016/j.bbagen.2011.04.007_bb0150 article-title: Cleavage of structural proteins during the assembly of the head of bacteriophage T4 publication-title: Nature doi: 10.1038/227680a0 – volume: 19 start-page: 360 year: 2009 ident: 10.1016/j.bbagen.2011.04.007_bb0255 article-title: Optimization of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine IGF-1R tyrosine kinase inhibitors towards JNK selectivity publication-title: Bioorg. Med. Chem. Lett. doi: 10.1016/j.bmcl.2008.11.077 – volume: 84 start-page: 329 year: 2004 ident: 10.1016/j.bbagen.2011.04.007_bb0065 article-title: Antioxidant activity of propolis of various geographic origins publication-title: Food Chem. doi: 10.1016/S0308-8146(03)00216-4 – volume: 23 start-page: 1431 year: 2009 ident: 10.1016/j.bbagen.2011.04.007_bb0120 article-title: Neuroprotective effects of Brazilian green propolis and its main constituents against oxygen-glucose deprivation stress, with a gene-expression analysis publication-title: Phytother. Res. doi: 10.1002/ptr.2797 – volume: 7 start-page: 941 year: 2001 ident: 10.1016/j.bbagen.2011.04.007_bb0015 article-title: The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity publication-title: Nat. Med. doi: 10.1038/90984 – volume: 28 start-page: 1928 year: 2005 ident: 10.1016/j.bbagen.2011.04.007_bb0095 article-title: Effects of local administration of propolis and its polyphenolic compounds on tumor formation and growth publication-title: Biol. Pharm. Bull. doi: 10.1248/bpb.28.1928 – volume: 276 start-page: 48662 year: 2001 ident: 10.1016/j.bbagen.2011.04.007_bb0145 article-title: Hydrogen peroxide generated during cellular insulin stimulation is integral to activation of the distal insulin signaling cascade in 3T3-L1 adipcytes publication-title: J. Biol. Chem. doi: 10.1074/jbc.M105061200 – volume: 424 start-page: 181 year: 2004 ident: 10.1016/j.bbagen.2011.04.007_bb0260 article-title: Antioxidative bioavailability of artepillin C in Brazilian propolis publication-title: Arch. Biochem. Biophys. doi: 10.1016/j.abb.2004.02.021 – volume: 514 start-page: 315 year: 2002 ident: 10.1016/j.bbagen.2011.04.007_bb0140 article-title: Dual action of isoprenols from herbal medicines on both PPARγ and PPARα in 3T3-L1 adipocytes and HepG2 hepatocytes publication-title: FEBS Lett. doi: 10.1016/S0014-5793(02)02390-6 – volume: 10 start-page: 1128 year: 2004 ident: 10.1016/j.bbagen.2011.04.007_bb0235 article-title: Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide publication-title: Nat. Med. doi: 10.1038/nm1111 – volume: 283 start-page: 1266 year: 2002 ident: 10.1016/j.bbagen.2011.04.007_bb0005 article-title: Adiponectin is stimulated by adrenalectomy in ob/ob mice and is highly correlated with resistin mRNA publication-title: Am. J. Physiol. Endocrinol. Metab. doi: 10.1152/ajpendo.00227.2002 – volume: 280 start-page: 1384 year: 2005 ident: 10.1016/j.bbagen.2011.04.007_bb0155 article-title: Use of photoaffinity labeling and site-directed mutagenesis for identification of the key residue responsible for extraordinarily high affinity binding of UCN-01 in human α1-acid glycoprotein publication-title: J. Biol. Chem. doi: 10.1074/jbc.M411076200 – volume: 15 start-page: 353 year: 1981 ident: 10.1016/j.bbagen.2011.04.007_bb0185 article-title: Prediction of proton magnetic resonance shifts: the dependence on hydrogen charges obtained by iterative partial equalization of orbital electronegativity publication-title: Magn. Reson. Chem. – volume: 27 start-page: 84 year: 2007 ident: 10.1016/j.bbagen.2011.04.007_bb0040 article-title: Role of the toll-like receptor 4/NF-kB pathway in saturated fatty acid-induced inflammatory changes in the interaction between adipocytes and macrophages publication-title: Arterioscler. Thromb. Vasc. Biol. doi: 10.1161/01.ATV.0000251608.09329.9a – volume: 31 start-page: 3 year: 2000 ident: 10.1016/j.bbagen.2011.04.007_bb0055 article-title: Propolis: recent advances in chemistry and plant origin publication-title: Apidologie doi: 10.1051/apido:2000102 – volume: 53 start-page: 9928 year: 2005 ident: 10.1016/j.bbagen.2011.04.007_bb0265 article-title: Absorption and bioavailability of artepillin C in rats after oral administration publication-title: J. Agric. Food Chem. doi: 10.1021/jf051962y |
| SSID | ssj0000595 ssj0025309 |
| Score | 2.1601999 |
| Snippet | Previous reports suggest that Brazilian propolis has multiple biological functions and may help to restore adiponectin expression and insulin sensitivity.... BACKGROUND: Previous reports suggest that Brazilian propolis has multiple biological functions and may help to restore adiponectin expression and insulin... |
| SourceID | proquest pubmed crossref elsevier |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 695 |
| SubjectTerms | 3T3-L1 Cells Adipocyte adipocytes Adipocytes - drug effects Adipocytes - metabolism Adiponectin Adiponectin - metabolism agonists Anilides - pharmacology Animals Anthracenes - chemistry Anthracenes - pharmacology Brazil c-Jun-NH2-terminal kinase Coumaric Acids - chemistry Coumaric Acids - pharmacology Crystallography, X-Ray Down-Regulation - drug effects Enzyme Activation - drug effects fatty acid-binding proteins Immunoblotting insulin resistance JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors JNK Mitogen-Activated Protein Kinases - chemistry JNK Mitogen-Activated Protein Kinases - metabolism Mice mitogen-activated protein kinase Models, Molecular molecular models Molecular Structure necrosis Peroxisome proliferator-activated receptor Phenylpropionates - chemistry Phenylpropionates - pharmacology PPAR gamma - agonists PPAR gamma - chemistry PPAR gamma - metabolism Propolis Propolis - chemistry Propolis - pharmacology Protein Binding - drug effects transcription (genetics) transcriptional activation tumor necrosis factor-alpha Tumor Necrosis Factor-alpha - pharmacology |
| Title | Brazilian propolis-derived components inhibit TNF-α-mediated downregulation of adiponectin expression via different mechanisms in 3T3-L1 adipocytes |
| URI | https://dx.doi.org/10.1016/j.bbagen.2011.04.007 https://www.ncbi.nlm.nih.gov/pubmed/21554928 https://www.proquest.com/docview/2000015904 https://www.proquest.com/docview/869582299 |
| Volume | 1810 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELaqIgQXBOW1PCojcTWbxHYSH8uK1cLCHmAreov8impEs6vdtKIc-BX8Ef4Iv4mZOCnisKrEKVLksUae8cxnex6EvLSpNbnWjhXaZUwo7pjOM8NAu6QosjrxOSYKf1jks2Px7kSe7JHJkAuDYZW97Y82vbPW_Z9xv5rjdQjjT_ioB3BCYtGzpBSYaC5EgVr-6sffMA-ADzK-JAiGo4f0uS7GyxjYtE1fyLMro73LPe2Cn50bmt4ld3r8SI8ii_fInm8OyM3YUfLygNyaDA3c7pOfrzf6e8BrDLrueiGELXOgcBfeUYwkXzUYREFDcxpMaOlyMWW_f7EulQRgKHVwPt_ETvUgO7qqqXYBicBCNtR_6yNoG3oRNB36rLT0zGMucdie4cyULzl7n0ZKewmw9gE5nr5ZTmasb8LALFeiZdoXuRe1KeEka3SiS0AciMLSsgQoqAqncps7XXOpbZoVxqe-1Al4XolJr8bwh2S_Ad4eE6qkUpbXcOCCWZTJtBFAya0DNZJc-hHhw9pXtq9Qjo0yvlZDKNqXKkqsQolViahAYiPCrqjWsULHNeOLQazVP5pWgRO5hvLFoAUViBJfVnTjV-db7OWJ4FMlYkTojjFlriRW11cj8ihq0BW7GYI6lZVP_pu1p-R2vOzGOOJnZL_dnPvngJZac9hth0Ny4-jtfLbA7_zj5_kfFH0Y2w |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3NbtQwELZKESoXBOVv-TUSV7NJbCfxEVasFtjuha3Um2XHjmpEs6vdtKIceApehBfhmZiJkyIOq0pcI49lecYzn-OZ-Qh5XaWVzY1xrDAuY0Jxx0yeWQbWJUWR1YnPsVD4aJHPjsXHE3myRyZDLQymVfa-P_r0zlv3X8b9bo7XIYw_46MewAmJTc-SUsgb5KaA44s0Bm9-_M3zAPwg41OCYDh8qJ_rkryshVPb9J08uz7au-LTLvzZxaHpXXKnB5D0bVzjPbLnm0NyK1JKXh6Sg8nA4Haf_Hy3Md8D_seg644MIWyZA4u78I5iKvmqwSwKGprTYENLl4sp-_2LdbUkgEOpgwv6JlLVg_LoqqbGBRQCF9lQ_61PoW3oRTB0IFpp6ZnHYuKwPcOZKV9yNk-jZHUJuPYBOZ6-X05mrGdhYBVXomXGF7kXtS3hKmtNYkqAHAjD0rIELKgKp_Iqd6bm0lRpVlif-tIkEHolVr1ayx-S_QbW9phQJZWqeA03LphF2cxYAZK8cmBHkks_InzYe131LcqRKeOrHnLRvuioMY0a04nQoLERYVdS69ii45rxxaBW_Y-paYgi10i-GqxAgyrxacU0fnW-RTJPRJ8qESNCd4wpcyWxvb4akUfRgq6WmyGqU1n55L-X9pIczJZHcz3_sPj0lNyOf74xqfgZ2W835_45QKfWvuiOxh-InRjG |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Brazilian+propolis-derived+components+inhibit+TNF-%CE%B1-mediated+downregulation+of+adiponectin+expression+via+different+mechanisms+in+3T3-L1+adipocytes&rft.jtitle=Biochimica+et+biophysica+acta&rft.au=Ikeda%2C+Rie&rft.au=Yanagisawa%2C+Masayoshi&rft.au=Takahashi%2C+Nobuyuki&rft.au=Kawada%2C+Teruo&rft.date=2011-07-01&rft.issn=0006-3002&rft.volume=1810&rft.issue=7&rft.spage=695&rft_id=info:doi/10.1016%2Fj.bbagen.2011.04.007&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0304-4165&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0304-4165&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0304-4165&client=summon |