Baseline folic acid status affects the effectiveness of folic acid supplements in cognitively relevant outcomes in older adults: a systematic review

• Published in: Aging & mental health Vol. 26; no. 3; pp. 457 - 463
• Main Authors: Huang, Ling, Zhao, Jing, Chen, Yongjie, Ma, Fei, Huang, Guowei, Li, Wen
• Format: Journal Article
• Language: English
• Published: England Routledge 04.03.2022; Taylor & Francis Ltd
• Subjects: a systematic review; Acids; Adults; Aged; Alzheimer's disease; Atrophy; Atrophy - complications; Brain; Brain atrophy; Clinical trials; Cognition; Cognition Disorders - etiology; Cognitive ability; Cognitive functioning; Cognitive results; Dietary Supplements; Folic acid; Folic Acid - therapeutic use; Geriatric psychiatry; Humans; Magnetic resonance imaging; Medical research; Neurodegenerative diseases; Neuroimaging; Older people; Randomized controlled trials; Risk factors; Supplements; Systematic review; The elderly; Vitamin B; a systematic review; folic acid; Cognitive results; Randomized controlled trials; The elderly

Folic acid was investigated for decreased concentrations of the same type of cysteine (Hcy), which is considered a risk factor for Alzheimer's disease. However, the conclusions are inconsistent, while supplementing elders with different folic acid states. The PubMed, Science Network and EMBASE...