Baseline folic acid status affects the effectiveness of folic acid supplements in cognitively relevant outcomes in older adults: a systematic review

Folic acid was investigated for decreased concentrations of the same type of cysteine (Hcy), which is considered a risk factor for Alzheimer's disease. However, the conclusions are inconsistent, while supplementing elders with different folic acid states. The PubMed, Science Network and EMBASE...

Full description

Saved in:
Bibliographic Details
Published inAging & mental health Vol. 26; no. 3; pp. 457 - 463
Main Authors Huang, Ling, Zhao, Jing, Chen, Yongjie, Ma, Fei, Huang, Guowei, Li, Wen
Format Journal Article
LanguageEnglish
Published England Routledge 04.03.2022
Taylor & Francis Ltd
Subjects
a systematic review
Acids
Adults
Aged
Alzheimer's disease
Atrophy
Atrophy - complications
Brain
Brain atrophy
Clinical trials
Cognition
Cognition Disorders - etiology
Cognitive ability
Cognitive functioning
Cognitive results
Dietary Supplements
Folic acid
Folic Acid - therapeutic use
Geriatric psychiatry
Humans
Magnetic resonance imaging
Medical research
Neurodegenerative diseases
Neuroimaging
Older people
Randomized controlled trials
Risk factors
Supplements
Systematic review
The elderly
Vitamin B
a systematic review
folic acid
Cognitive results
Randomized controlled trials
The elderly
Online AccessGet full text

Cover

Abstract Folic acid was investigated for decreased concentrations of the same type of cysteine (Hcy), which is considered a risk factor for Alzheimer's disease. However, the conclusions are inconsistent, while supplementing elders with different folic acid states. The PubMed, Science Network and EMBASE databases were searched for randomized controlled trials published over the past decade; The 11/485 study was included on the basis of pre-defined criteria. Cognitive-related results, including cognitive function and brain atrophy, were measured using cognitive scales and magnetic resonance imaging. Significant cognitive benefits were reported in individuals with incomplete folic acid (n s 4); However, individuals with sufficient folic acid (n s 2) do not benefit from supplements, evaluated by the cognitive scale. On the other hand, a significant positive association was established in the participants of plasma Hcy, but the folic acid state was sufficient (n s 2). One study reported that folic acid supplements did not provide any benefit, but folic acid status data were missing. In addition, folic acid supplementation also improves brain atrophy (n s 2). Baseline folic acid status may be a potential factor affecting the results of cognitive function folic acid supplementation in older adults. Older people with insufficient folic acid will benefit from folic acid supplementation.
AbstractList Folic acid was investigated for decreased concentrations of the same type of cysteine (Hcy), which is considered a risk factor for Alzheimer's disease. However, the conclusions are inconsistent, while supplementing elders with different folic acid states. The PubMed, Science Network and EMBASE databases were searched for randomized controlled trials published over the past decade; The 11/485 study was included on the basis of pre-defined criteria. Cognitive-related results, including cognitive function and brain atrophy, were measured using cognitive scales and magnetic resonance imaging. Significant cognitive benefits were reported in individuals with incomplete folic acid (n s 4); However, individuals with sufficient folic acid (n s 2) do not benefit from supplements, evaluated by the cognitive scale. On the other hand, a significant positive association was established in the participants of plasma Hcy, but the folic acid state was sufficient (n s 2). One study reported that folic acid supplements did not provide any benefit, but folic acid status data were missing. In addition, folic acid supplementation also improves brain atrophy (n s 2). Baseline folic acid status may be a potential factor affecting the results of cognitive function folic acid supplementation in older adults. Older people with insufficient folic acid will benefit from folic acid supplementation.
Folic acid was investigated for decreased concentrations of the same type of cysteine (Hcy), which is considered a risk factor for Alzheimer's disease. However, the conclusions are inconsistent, while supplementing elders with different folic acid states.BACKGROUNDFolic acid was investigated for decreased concentrations of the same type of cysteine (Hcy), which is considered a risk factor for Alzheimer's disease. However, the conclusions are inconsistent, while supplementing elders with different folic acid states.The PubMed, Science Network and EMBASE databases were searched for randomized controlled trials published over the past decade; The 11/485 study was included on the basis of pre-defined criteria. Cognitive-related results, including cognitive function and brain atrophy, were measured using cognitive scales and magnetic resonance imaging.METHODThe PubMed, Science Network and EMBASE databases were searched for randomized controlled trials published over the past decade; The 11/485 study was included on the basis of pre-defined criteria. Cognitive-related results, including cognitive function and brain atrophy, were measured using cognitive scales and magnetic resonance imaging.Significant cognitive benefits were reported in individuals with incomplete folic acid (n s 4); However, individuals with sufficient folic acid (n s 2) do not benefit from supplements, evaluated by the cognitive scale. On the other hand, a significant positive association was established in the participants of plasma Hcy, but the folic acid state was sufficient (n s 2). One study reported that folic acid supplements did not provide any benefit, but folic acid status data were missing. In addition, folic acid supplementation also improves brain atrophy (n s 2).RESULTSSignificant cognitive benefits were reported in individuals with incomplete folic acid (n s 4); However, individuals with sufficient folic acid (n s 2) do not benefit from supplements, evaluated by the cognitive scale. On the other hand, a significant positive association was established in the participants of plasma Hcy, but the folic acid state was sufficient (n s 2). One study reported that folic acid supplements did not provide any benefit, but folic acid status data were missing. In addition, folic acid supplementation also improves brain atrophy (n s 2).Baseline folic acid status may be a potential factor affecting the results of cognitive function folic acid supplementation in older adults. Older people with insufficient folic acid will benefit from folic acid supplementation.CONCLUSIONBaseline folic acid status may be a potential factor affecting the results of cognitive function folic acid supplementation in older adults. Older people with insufficient folic acid will benefit from folic acid supplementation.
Folic acid was investigated for decreased concentrations of the same type of cysteine (Hcy), which is considered a risk factor for Alzheimer's disease. However, the conclusions are inconsistent, while supplementing elders with different folic acid states. The PubMed, Science Network and EMBASE databases were searched for randomized controlled trials published over the past decade; The 11/485 study was included on the basis of pre-defined criteria. Cognitive-related results, including cognitive function and brain atrophy, were measured using cognitive scales and magnetic resonance imaging. Significant cognitive benefits were reported in individuals with incomplete folic acid s 4); However, individuals with sufficient s 2) do not benefit from supplements, evaluated by the cognitive scale. On the other hand, a significant positive association was established in the participants of plasma Hcy, but the folic acid state was sufficient s 2). One study reported that folic acid supplements did not provide any benefit, but folic acid status data were missing. In addition, folic acid supplementation also improves brain s 2). Baseline folic acid status may be a potential factor affecting the results of cognitive function folic acid supplementation in older adults. Older people with insufficient folic acid will benefit from folic acid supplementation.
BackgroundFolic acid was investigated for decreased concentrations of the same type of cysteine (Hcy), which is considered a risk factor for Alzheimer's disease. However, the conclusions are inconsistent, while supplementing elders with different folic acid states.MethodThe PubMed, Science Network and EMBASE databases were searched for randomized controlled trials published over the past decade; The 11/485 study was included on the basis of pre-defined criteria. Cognitive-related results, including cognitive function and brain atrophy, were measured using cognitive scales and magnetic resonance imaging.ResultsSignificant cognitive benefits were reported in individuals with incomplete folic acid (n s 4); However, individuals with sufficient folic acid (n s 2) do not benefit from supplements, evaluated by the cognitive scale. On the other hand, a significant positive association was established in the participants of plasma Hcy, but the folic acid state was sufficient (n s 2). One study reported that folic acid supplements did not provide any benefit, but folic acid status data were missing. In addition, folic acid supplementation also improves brain atrophy (n s 2).ConclusionBaseline folic acid status may be a potential factor affecting the results of cognitive function folic acid supplementation in older adults. Older people with insufficient folic acid will benefit from folic acid supplementation.
Author Huang, Guowei
Ma, Fei
Li, Wen
Huang, Ling
Zhao, Jing
Chen, Yongjie
Author_xml – sequence: 1
  givenname: Ling
  surname: Huang
  fullname: Huang, Ling
  organization: Department of Nutrition and Food Science, School of Public Health, Tianjin Medical
– sequence: 2
  givenname: Jing
  surname: Zhao
  fullname: Zhao, Jing
  organization: Department of Nutrition and Food Science, School of Public Health, Tianjin Medical
– sequence: 3
  givenname: Yongjie
  surname: Chen
  fullname: Chen, Yongjie
  organization: Tianjin Key Laboratory for Environment, Nutrition and Public Health
– sequence: 4
  givenname: Fei
  surname: Ma
  fullname: Ma, Fei
  organization: Tianjin Key Laboratory for Environment, Nutrition and Public Health
– sequence: 5
  givenname: Guowei
  surname: Huang
  fullname: Huang, Guowei
  organization: Tianjin Key Laboratory for Environment, Nutrition and Public Health
– sequence: 6
  givenname: Wen
  surname: Li
  fullname: Li, Wen
  organization: Tianjin Key Laboratory for Environment, Nutrition and Public Health
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33463361$$D View this record in MEDLINE/PubMed
BookMark eNqFkcuOFCEUhokZ41z0ETQkbtxUCwVFUboZnXhLJnGja0JRB2VCQQtUT_o9fGDp28JZ6IoT8v3_ufyX6CzEAAg9p2RFiSSvKROkl4KtWtLSFZV9Rwf-CF3Uf96IgXZn-5o0O-gcXeZ8RwihnIon6JwxLhgT9AL9fq8zeBcA2-idwdq4Ceeiy5KxthZMybj8BAz72m0gQM442r_wZb32MEOorAvYxB_B7VC_xQk8bHQoOC7FxBn2QPQTJKynxZf8Bmuct7nArEv1S7BxcP8UPbbaZ3h2fK_Q948fvt18bm6_fvpy8-62MWzgpdGSjGLoe2MABmnlaEjfdnocR8ZHIwbNBbQTJ4yOVDJCu45xYluhNR2IHCy7Qq8OvusUfy2Qi5pdNuC9DhCXrFreD4T1UsqKvnyA3sUlhTqdYmRgknd9yyr14kgt4wyTWic367RVp3tX4O0BMCnmnMAq4-qxXQwlaecVJWqXrjqlq3bpqmO6Vd09UJ8a_E93fdC5YGOa9X1MflJFb31MNulgXN3i3xZ_AJDEvPc
CitedBy_id crossref_primary_10_3390_nu16142199
crossref_primary_10_3390_ijms23147935
crossref_primary_10_3390_nu16152503
Cites_doi 10.1186/s12929-018-0495-4
10.1007/s00213-011-2481-3
10.1590/1806-9282.62.01.90
10.1001/jama.300.15.1774
10.1017/S0007114511000158
10.1212/WNL.0000000000001050
10.1073/pnas.1301816110
10.1016/j.clnu.2019.11.005
10.1001/archneur.64.1.86
10.1007/s00394-017-1598-5
10.1016/j.clnu.2010.12.004
10.3233/JAD-150057
10.1111/joim.12191
10.1371/journal.pone.0012244
10.1016/j.jalz.2018.04.008
10.1186/s12929-017-0355-7
10.1038/srep37486
10.3233/JAD-142499
10.1093/ajcn/84.2.361
10.1016/S0140-6736(07)60109-3
10.1016/j.jnutbio.2012.11.001
10.1007/s11357-015-9782-0
10.1002/dneu.22579
10.1093/gerona/glv183
10.1212/WNL.0b013e3181f962c4
10.1146/annurev-nutr-071715-050947
10.1002/hup.2236
10.1016/j.jnutbio.2015.03.009
10.2147/CIA.S211739
10.1093/gerona/glv109
10.1017/S0007114520000719
10.7326/0003-4819-159-12-201312170-00006
10.3945/ajcn.110.007799
10.5114/fn.2019.85929
10.1016/j.biochi.2015.11.006
10.2478/jomb-2013-0033
10.3390/nu7053796
10.1080/07315724.2014.880660
10.1186/alzrt224
10.1002/gps.2758
10.3390/nu12010247
ContentType Journal Article
Copyright 2021 Informa UK Limited, trading as Taylor & Francis Group 2021
2021 Informa UK Limited, trading as Taylor & Francis Group
Copyright_xml – notice: 2021 Informa UK Limited, trading as Taylor & Francis Group 2021
– notice: 2021 Informa UK Limited, trading as Taylor & Francis Group
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7QJ
7QL
7T7
7TK
7U4
7U9
8BJ
8FD
BHHNA
C1K
DWI
FQK
FR3
H94
JBE
M7N
NAPCQ
P64
WZK
7X8
DOI 10.1080/13607863.2021.1875194
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
Applied Social Sciences Index & Abstracts (ASSIA)
Bacteriology Abstracts (Microbiology B)
Industrial and Applied Microbiology Abstracts (Microbiology A)
Neurosciences Abstracts
Sociological Abstracts (pre-2017)
Virology and AIDS Abstracts
International Bibliography of the Social Sciences (IBSS)
Technology Research Database
Sociological Abstracts
Environmental Sciences and Pollution Management
Sociological Abstracts
International Bibliography of the Social Sciences
Engineering Research Database
AIDS and Cancer Research Abstracts
International Bibliography of the Social Sciences
Algology Mycology and Protozoology Abstracts (Microbiology C)
Nursing & Allied Health Premium
Biotechnology and BioEngineering Abstracts
Sociological Abstracts (Ovid)
MEDLINE - Academic
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Virology and AIDS Abstracts
Technology Research Database
Applied Social Sciences Index and Abstracts (ASSIA)
Neurosciences Abstracts
Biotechnology and BioEngineering Abstracts
Environmental Sciences and Pollution Management
Sociological Abstracts (pre-2017)
Nursing & Allied Health Premium
International Bibliography of the Social Sciences (IBSS)
Bacteriology Abstracts (Microbiology B)
Sociological Abstracts
Algology Mycology and Protozoology Abstracts (Microbiology C)
AIDS and Cancer Research Abstracts
Engineering Research Database
Industrial and Applied Microbiology Abstracts (Microbiology A)
MEDLINE - Academic
DatabaseTitleList
MEDLINE - Academic
MEDLINE
Virology and AIDS Abstracts
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Psychology
EISSN 1364-6915
EndPage 463
ExternalDocumentID 33463361
10_1080_13607863_2021_1875194
1875194
Genre Review
Research Support, Non-U.S. Gov't
Systematic Review
Journal Article
GroupedDBID ---
-~X
.7I
.QK
04C
0BK
0R~
23M
2DF
36B
4.4
53G
5GY
5VS
6PF
AAGZJ
AAMFJ
AAMIU
AAPUL
AATTQ
AAWTL
AAZMC
ABCCY
ABDBF
ABFIM
ABIVO
ABJNI
ABLIJ
ABPEM
ABTAI
ABXUL
ABXYU
ABZLS
ACGEJ
ACGFS
ACHQT
ACTIO
ACTOA
ADAHI
ADBBV
ADCVX
ADKVQ
ADOJX
ADXPE
ADZJE
AECIN
AEISY
AEKEX
AEMXT
AENEX
AEOZL
AEPSL
AEYOC
AEZRU
AGDLA
AGMYJ
AGRBW
AHDZW
AIJEM
AJWEG
AKBVH
ALMA_UNASSIGNED_HOLDINGS
ALQZU
AVBZW
AWYRJ
BEJHT
BLEHA
BMOTO
BMSDO
BOHLJ
CCCUG
CQ1
CS3
DGFLZ
DKSSO
EAP
EAS
EBS
ECF
ECT
ECV
EHN
EIHBH
EMB
ENB
ENC
ENX
EPS
EPT
ESI
ESX
E~B
E~C
F5P
FEDTE
G-F
GTTXZ
H13
HF~
HVGLF
HZ~
IPNFZ
J.O
KSSTO
KYCEM
LGLTD
LJTGL
M4Z
NA5
O9-
P2P
Q~Q
RIG
RNANH
ROSJB
RSYQP
S-F
STATR
SV3
TBQAZ
TDBHL
TEH
TFH
TFL
TFW
TNJ
TNTFI
TRJHH
TUROJ
UT5
UT9
VAE
WQ9
~01
~S~
AAGDL
AAHIA
AAYXX
ADYSH
AEFOU
AFRVT
AIYEW
AMPGV
CITATION
4H-
AACLK
AAIFK
ABITY
ABLUQ
ABYAV
AFUSO
CAG
CGR
COF
CUY
CVF
DAOCQ
DTEEQ
DYOWO
ECM
EIF
EJD
NPM
PPYGK
TASJS
7QJ
7QL
7T7
7TK
7U4
7U9
8BJ
8FD
BHHNA
C1K
DWI
FQK
FR3
H94
JBE
M7N
NAPCQ
P64
WZK
7X8
ID FETCH-LOGICAL-c394t-a80b6977ccee98f8bc0725abbb34bc69a46e2d4031b1830155340f26aa19089f3
ISSN 1360-7863
1364-6915
IngestDate Fri Jul 11 10:44:51 EDT 2025
Sun Jul 13 04:18:49 EDT 2025
Mon Jul 21 05:56:55 EDT 2025
Tue Jul 01 02:24:47 EDT 2025
Thu Apr 24 23:06:07 EDT 2025
Wed Dec 25 09:07:25 EST 2024
IsPeerReviewed true
IsScholarly true
Issue 3
Keywords a systematic review
folic acid
Cognitive results
Randomized controlled trials
The elderly
Language English
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c394t-a80b6977ccee98f8bc0725abbb34bc69a46e2d4031b1830155340f26aa19089f3
Notes ObjectType-Article-2
SourceType-Scholarly Journals-1
content type line 14
ObjectType-Feature-3
ObjectType-Evidence Based Healthcare-1
ObjectType-Article-1
ObjectType-Feature-2
content type line 23
ObjectType-Undefined-3
PMID 33463361
PQID 3093845723
PQPubID 53150
PageCount 7
ParticipantIDs informaworld_taylorfrancis_310_1080_13607863_2021_1875194
crossref_citationtrail_10_1080_13607863_2021_1875194
proquest_miscellaneous_2479037888
proquest_journals_3093845723
crossref_primary_10_1080_13607863_2021_1875194
pubmed_primary_33463361
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2022-03-04
PublicationDateYYYYMMDD 2022-03-04
PublicationDate_xml – month: 03
  year: 2022
  text: 2022-03-04
  day: 04
PublicationDecade 2020
PublicationPlace England
PublicationPlace_xml – name: England
– name: Abingdon
PublicationTitle Aging & mental health
PublicationTitleAlternate Aging Ment Health
PublicationYear 2022
Publisher Routledge
Taylor & Francis Ltd
Publisher_xml – name: Routledge
– name: Taylor & Francis Ltd
References CIT0030
CIT0012
CIT0034
CIT0011
CIT0033
Grodstein F. (CIT0014) 2013; 159
Balashova O. A. (CIT0004) 2018; 78
Silva M. V. F. (CIT0041) 2019; 26
Eussen S. J. (CIT0010) 2006; 84
CIT0035
Ford A. H. (CIT0013) 2010; 75
CIT0016
CIT0038
CIT0015
CIT0037
CIT0017
CIT0039
CIT0019
Malouf R. (CIT0028) 2008
CIT0040
CIT0021
CIT0043
CIT0020
CIT0042
CIT0001
CIT0023
CIT0045
CIT0022
CIT0044
McCleery J. (CIT0031) 2018; 11
Murphy M. E. (CIT0032) 2020; 12
Macpherson H. (CIT0026) 2015; 37
Rasmussen J. (CIT0036) 2019; 14
Chen H. (CIT0006) 2016; 2016
Jiang, B. (CIT0018) 2013; 33
CIT0003
CIT0025
CIT0047
CIT0024
CIT0046
CIT0005
CIT0027
CIT0007
CIT0029
CIT0009
Alpers D. H. (CIT0002) 2016; 126
CIT0008
References_xml – volume: 26
  start-page: 1
  issue: 1
  year: 2019
  ident: CIT0041
  publication-title: Journal of Biomedical Science
  doi: 10.1186/s12929-018-0495-4
– ident: CIT0025
  doi: 10.1007/s00213-011-2481-3
– volume: 11
  issue: 11
  year: 2018
  ident: CIT0031
  publication-title: Cochrane Database of Systematic Reviews
– ident: CIT0021
  doi: 10.1590/1806-9282.62.01.90
– ident: CIT0001
  doi: 10.1001/jama.300.15.1774
– ident: CIT0005
  doi: 10.1017/S0007114511000158
– issue: 4
  year: 2008
  ident: CIT0028
  publication-title: Cochrane Database of Systematic Reviews
– ident: CIT0045
  doi: 10.1212/WNL.0000000000001050
– ident: CIT0008
  doi: 10.1073/pnas.1301816110
– ident: CIT0020
  doi: 10.1016/j.clnu.2019.11.005
– ident: CIT0024
  doi: 10.1001/archneur.64.1.86
– ident: CIT0027
  doi: 10.1007/s00394-017-1598-5
– volume: 2016
  start-page: 1
  year: 2016
  ident: CIT0006
  publication-title: Mediators of Inflammation
– ident: CIT0019
  doi: 10.1016/j.clnu.2010.12.004
– ident: CIT0038
  doi: 10.3233/JAD-150057
– ident: CIT0039
  doi: 10.1111/joim.12191
– ident: CIT0043
  doi: 10.1371/journal.pone.0012244
– ident: CIT0033
  doi: 10.1016/j.jalz.2018.04.008
– ident: CIT0017
  doi: 10.1186/s12929-017-0355-7
– ident: CIT0035
– ident: CIT0030
  doi: 10.1038/srep37486
– ident: CIT0037
  doi: 10.3233/JAD-142499
– volume: 84
  start-page: 361
  issue: 2
  year: 2006
  ident: CIT0010
  publication-title: The American Journal of Clinical Nutrition
  doi: 10.1093/ajcn/84.2.361
– ident: CIT0009
  doi: 10.1016/S0140-6736(07)60109-3
– ident: CIT0023
  doi: 10.1016/j.jnutbio.2012.11.001
– volume: 37
  issue: 3
  year: 2015
  ident: CIT0026
  publication-title: Age
  doi: 10.1007/s11357-015-9782-0
– volume: 78
  start-page: 391
  issue: 4
  year: 2018
  ident: CIT0004
  publication-title: Developmental Neurobiology
  doi: 10.1002/dneu.22579
– ident: CIT0029
  doi: 10.1093/gerona/glv183
– volume: 75
  start-page: 1540
  issue: 17
  year: 2010
  ident: CIT0013
  publication-title: Neurology
  doi: 10.1212/WNL.0b013e3181f962c4
– ident: CIT0042
  doi: 10.1146/annurev-nutr-071715-050947
– ident: CIT0012
– ident: CIT0016
  doi: 10.1002/hup.2236
– ident: CIT0022
  doi: 10.1016/j.jnutbio.2015.03.009
– volume: 14
  start-page: 1481
  year: 2019
  ident: CIT0036
  publication-title: Clinical Interventions in Aging
  doi: 10.2147/CIA.S211739
– ident: CIT0044
  doi: 10.1093/gerona/glv109
– ident: CIT0047
– ident: CIT0011
  doi: 10.1017/S0007114520000719
– volume: 159
  start-page: 806
  issue: 12
  year: 2013
  ident: CIT0014
  publication-title: Annals of Internal Medicine
  doi: 10.7326/0003-4819-159-12-201312170-00006
– ident: CIT0046
  doi: 10.3945/ajcn.110.007799
– ident: CIT0003
  doi: 10.5114/fn.2019.85929
– volume: 126
  start-page: 52
  year: 2016
  ident: CIT0002
  publication-title: Biochimie
  doi: 10.1016/j.biochi.2015.11.006
– volume: 33
  start-page: 169
  issue: 2
  year: 2013
  ident: CIT0018
  publication-title: Journal of Medical Biochemistry
  doi: 10.2478/jomb-2013-0033
– ident: CIT0015
  doi: 10.3390/nu7053796
– ident: CIT0034
  doi: 10.1080/07315724.2014.880660
– ident: CIT0040
  doi: 10.1186/alzrt224
– ident: CIT0007
  doi: 10.1002/gps.2758
– volume: 12
  start-page: 247
  issue: 1
  year: 2020
  ident: CIT0032
  publication-title: Nutrients
  doi: 10.3390/nu12010247
SSID ssj0001416
Score 2.3356304
SecondaryResourceType review_article
Snippet Folic acid was investigated for decreased concentrations of the same type of cysteine (Hcy), which is considered a risk factor for Alzheimer's disease....
BackgroundFolic acid was investigated for decreased concentrations of the same type of cysteine (Hcy), which is considered a risk factor for Alzheimer's...
SourceID proquest
pubmed
crossref
informaworld
SourceType Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 457
SubjectTerms a systematic review
Acids
Adults
Aged
Alzheimer's disease
Atrophy
Atrophy - complications
Brain
Brain atrophy
Clinical trials
Cognition
Cognition Disorders - etiology
Cognitive ability
Cognitive functioning
Cognitive results
Dietary Supplements
Folic acid
Folic Acid - therapeutic use
Geriatric psychiatry
Humans
Magnetic resonance imaging
Medical research
Neurodegenerative diseases
Neuroimaging
Older people
Randomized controlled trials
Risk factors
Supplements
Systematic review
The elderly
Vitamin B
Title Baseline folic acid status affects the effectiveness of folic acid supplements in cognitively relevant outcomes in older adults: a systematic review
URI https://www.tandfonline.com/doi/abs/10.1080/13607863.2021.1875194
https://www.ncbi.nlm.nih.gov/pubmed/33463361
https://www.proquest.com/docview/3093845723
https://www.proquest.com/docview/2479037888
Volume 26
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwFLZKJ6G9IBi3wkBG4q1KSGLXTXgb06Zq6oaEUqk8RXHiTEUjQTQRGj-BZ34wx5ckDhRt8BJVjp24Ol_OzeeC0GtOGA9zQpy88EKHZpQ5YU4Lh3gwXfB5nqvOc-cXbLGiZ-vZejT6YUUtNTV3s-8780r-h6owBnSVWbL_QNnuoTAAv4G-cAUKw_VWNH6XqnRyWbdb1qpOs00ufQN1s52mJk6jj9lo2Rpoh_Z02dVT6Dw3FZJuoomurlU7FdCz62nV1LB7Fbk1rWRXb121Y6sTpX-vBf3N1nePLrUrgk0_23mXPZiMu3rZSlDtw9bHQdbYsUki-ViVl582VryuUr7FxnZegN0ro7eoxW8Jow6LdEanK3aMGSat0-oNGInFcamub_2HJNChk_As0IEYceHlvuuDcebrnsrDytsX75PT1XKZxCfr-A7aC8DkCMZoL_5wtlh0ct2nqpFut702Hyz03ux8zUDTGdTB_bs1o7Sa-D66Z8wRfKSx9QCNRHmA7p6bgIsDtN8JyOuH6GeLN6wAhCWAsMYbNnjDgDc8wBuuisH0Hm94U2ILb7jFG27xJicovGGNt7c4xT3asEbbI7Q6PYmPF47p6uFkJKK1k4YeZ2B1ZKCeRWER8sybB7OUc04oz1iUUiaCnIKw4SBuVF8r6hUBS1NfnlEX5DEal1UpniIc0ILMZxmNinkASlYAxo8gNIDHZGBGz8QE0ZYCSWZK3svOK1eJbyrjtoRLJOESQ7gJcrtlX3TNl5sWRDZ5k1o52wrdGSchN6w9bLGQGNYCS7yIhIDsgEzQq-42MH55mpeWomq2CfzjyJPdIMIJeqIx1O2WEMoIYf6zW6x-jvb7L_MQjeuvjXgBinbNX5ov4BcaPNFx
linkProvider Taylor & Francis
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwEB5BK0EvPMqjCwWMxDVL4nG8CTdAVKF0e0BbqbfIdmypapUgNjm0v4MfzNh50EWqeug5Hst27HnYM98H8EGj1FmFGFUuziJhhIyySrgIY2pu9aKqAvPc8lgWJ-LwND29Vgvj0yp9DO16oIigq_3h9pfRY0rcxwQlWTaJFN7xZJ6Qy02h-H3YTnOBFIBtr34eFsWkjxMRCFC9UOSlxjqemzrasFAb-KU3e6HBGh08BjPOo09COZ93rZ6bq_8gHu820SfwaHBW2ed-dz2Fe7behQfL4Tl-F3Ym9Xn5DP58UaG43TLnsYaZMmcV8_VK3ZqpPmuEkbfJ-gySQcmyxm009xyj4cJyzc5qNuU2XVwyT-5CXn_Lmq6lWdjQoPEc4yxgiKw_McX-4VKzvibnOZwcfFt9LaKB8yEymIs2UlmsJfmkhox3nrlMm3jBU6W1RqGNzJWQlleCVJEmZRRYj0TsuFQq8S-YDl_AVt3Udg8YFw4XqRG5W3AywZxcY4uCUzeGgqzUzkCM_7k0AyC65-W4KJMBN3Vc_tIvfzks_wzmk9ivHhHkNoH8-iYq23AV43relBJvkd0fd1w5KBcSiXPMRLrgOIP302dSC_6tR9W26dYlzTiPPVdANoOX_U6dRosoJKJMXt1hYO_gYbFaHpVH349_vIYd7otCfGae2Iet9ndn35Cr1uq3w1n8C9RbMQU
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwEB5BK1W98ChQFgoYiWuWxHachBuv1VJohVArcYtsx5YqqqQiyaH8Dn4w40cCi1T10HM8lu2MZ8b2zPcBvFJMqLJhLGlsWiZcc5GUDbcJS7G5UUXTeOa5o2OxPuWH3_Mpm7CPaZXuDG0DUIS31W5zXzR2yoh7nTGBjk0wPN3RbJlhxI0n8duwLdAfoZJvn3w7XK9nc5xxz3_qhBInNZXxXNXRhoPagC-9Ogj1zmh1F9Q0jZCD8mM5Dmqpf_2H8Hijed6DOzFUJW-Dbt2HW6bdg52j-Bi_B7uz8bx8AL_fSV_aboh1SMNE6rOGuGqlsScy5IwQjDVJyB-JJpZ0dqO5Yxj115U9OWvJnNl0fkkctQvG_APpxgEnYXyDzjGME48g0r8hkvxFpSahIuchnK4-nrxfJ5HxIdGs4kMiy1QJjEg1uu6qtKXSaUFzqZRiXGlRSS4MbTgaIoWmyHMe8dRSIWXm3i8tewRbbdeax0Aot6zINa9sQdEBUwyMDeMUu9F4xMrNAvj0m2sd4dAdK8d5nUXU1Gn5a7f8dVz-BSxnsYuAB3KdQPWvDtWDv4ixgTWlZtfIHkwKV0fTgiJpxUqeF5Qt4OX8GY2Ce-mRrenGvsYZV6ljCigXsB8UdR4tY1wwJrInNxjYC9j5-mFVf_l0_Pkp7FJXEeLS8vgBbA0_R_MM47RBPY878Q_iWS-p
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Baseline+folic+acid+status+affects+the+effectiveness+of+folic+acid+supplements+in+cognitively+relevant+outcomes+in+older+adults%3A+a+systematic+review&rft.jtitle=Aging+%26+mental+health&rft.au=Huang%2C+Ling&rft.au=Zhao%2C+Jing&rft.au=Chen%2C+Yongjie&rft.au=Ma%2C+Fei&rft.date=2022-03-04&rft.issn=1364-6915&rft.eissn=1364-6915&rft.volume=26&rft.issue=3&rft.spage=457&rft_id=info:doi/10.1080%2F13607863.2021.1875194&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1360-7863&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1360-7863&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1360-7863&client=summon