Protective Effect of Calcitriol on Organ Damage Induced by 5-Fluorouracil Treatment
Chemotherapy is a major therapeutic strategy for patients with cancer. Owing to the severe inflammatory response of chemotherapy, patients experience extreme discomfort during treatment, and this may interrupt treatment completion. The vitamin D3 has a role in anti-inflammation, but no study has exp...
Saved in:
Published in | Nutrition and cancer Vol. 73; no. 9; pp. 1687 - 1696 |
---|---|
Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Taylor & Francis
2021
Taylor & Francis Ltd |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Chemotherapy is a major therapeutic strategy for patients with cancer. Owing to the severe inflammatory response of chemotherapy, patients experience extreme discomfort during treatment, and this may interrupt treatment completion. The vitamin D3 has a role in anti-inflammation, but no study has explored whether vitamin D3 has beneficial effects on patients undergoing chemotherapy. In this study, we investigated the effect of calcitriol (Vit-D) on inflammatory responses during 5-fluorouracil (5-FU) treatment. Rats were divided into five groups and treated with 1:1 dilution of 5-FU with equal amount of 0.9% saline, 1:3 dilution of 5-FU with 0.9% saline threefold dilution, 5-FU, Vit-D, or 5-FU + Vit-D. A single dose of 15 mg/kg of 5-FU was intravenously administered for 4 h, and the blood biochemical substances and inflammatory cytokines were assessed after the intervention. The 5-FU group had higher AST, ALT, LDH, and CPK levels than those in the 5-FU + Vit-D group. The 5-FU + Vit-D group had a lower TNF-α value than the 5-FU. The IL-6 levels in the 5-FU + Vit-D group were also significantly lower than those in 5-FU. Calcitriol administration during 5-FU therapy can alleviate the production of inflammatory cytokines and liver damage. |
---|---|
AbstractList | Chemotherapy is a major therapeutic strategy for patients with cancer. Owing to the severe inflammatory response of chemotherapy, patients experience extreme discomfort during treatment, and this may interrupt treatment completion. The vitamin D3 has a role in anti-inflammation, but no study has explored whether vitamin D3 has beneficial effects on patients undergoing chemotherapy. In this study, we investigated the effect of calcitriol (Vit-D) on inflammatory responses during 5-fluorouracil (5-FU) treatment. Rats were divided into five groups and treated with 1:1 dilution of 5-FU with equal amount of 0.9% saline, 1:3 dilution of 5-FU with 0.9% saline threefold dilution, 5-FU, Vit-D, or 5-FU + Vit-D. A single dose of 15 mg/kg of 5-FU was intravenously administered for 4 h, and the blood biochemical substances and inflammatory cytokines were assessed after the intervention. The 5-FU group had higher AST, ALT, LDH, and CPK levels than those in the 5-FU + Vit-D group. The 5-FU + Vit-D group had a lower TNF-α value than the 5-FU. The IL-6 levels in the 5-FU + Vit-D group were also significantly lower than those in 5-FU. Calcitriol administration during 5-FU therapy can alleviate the production of inflammatory cytokines and liver damage. |
Author | Chen, Szu-Chi Ke, Chun-Yen Shiao, An-Suey Subeq, Yi-Maun Huang, Shyh-Geng Yang, Wan-Ting Lee, Ru-Ping |
Author_xml | – sequence: 1 givenname: Szu-Chi surname: Chen fullname: Chen, Szu-Chi organization: Department of Otolaryngology, Cheng Hsin General Hospital – sequence: 2 givenname: Chun-Yen surname: Ke fullname: Ke, Chun-Yen organization: Department of Nursing, Tzu Chi University of Science and Technology – sequence: 3 givenname: Yi-Maun surname: Subeq fullname: Subeq, Yi-Maun organization: Department of Nursing, National Taichung University of Science and Technology – sequence: 4 givenname: Wan-Ting surname: Yang fullname: Yang, Wan-Ting organization: Department of Orthopedics, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation – sequence: 5 givenname: Shyh-Geng surname: Huang fullname: Huang, Shyh-Geng organization: Institute of Medical Sciences, Tzu Chi University – sequence: 6 givenname: An-Suey surname: Shiao fullname: Shiao, An-Suey organization: Department of Otolaryngology, Cheng Hsin General Hospital – sequence: 7 givenname: Ru-Ping orcidid: 0000-0001-6624-5893 surname: Lee fullname: Lee, Ru-Ping organization: Institute of Medical Sciences, Tzu Chi University |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32777949$$D View this record in MEDLINE/PubMed |
BookMark | eNp9kE1LHTEUhkNR9PrxEyoBN92M5vtjp9xqKwgWquuQySQykkk0mbHcf98Z7tVFF12dw-E557w8R2Av5eQB-IrRBUYKXSIsKOcKXxBE5pFCTDP1Bawwp6SRGrM9sFqYZoEOwVGtLwghiak6AIeUSCk10yvw-1fJo3dj_-7hTQhzB3OAaxtdP5Y-R5gTfCjPNsHvdrDPHt6lbnK-g-0G8uY2TrnkqVjXR_hYvB0Hn8YTsB9srP50V4_B0-3N4_pnc__w4259fd84qtnYWORU5xQNQhLc8pYE1RIUhLBSME-otk4jjwXDXfCI-RnGiITAOxKwFpQeg2_bu68lv02-jmboq_Mx2uTzVA1hlCgutUYzev4P-jLHTnM6Q7ggQiBJF4pvKVdyrcUH81r6wZaNwcgs1s2HdbNYNzvr897Z7vrUDr773PrQPANXW6BPIZfB_skldma0m5hLKDa5vhr6_x9_ARLckVU |
CitedBy_id | crossref_primary_10_3390_jcm10194426 crossref_primary_10_2174_1389201023666211222165508 |
Cites_doi | 10.1016/j.oraloncology.2009.08.006 10.1530/ERC-12-0381 10.1038/nrc3691 10.1016/j.bbamcr.2018.05.015 10.1097/01.JNR.0000347584.00705.b8 10.1097/01.MIB.0000436957.77533.b2 10.1007/BF02256536 10.1038/nri.2017.1 10.1056/NEJMra070553 10.18632/oncotarget.14371 10.3748/wjg.v22.i18.4594 10.1146/annurev-pharmtox-010510-100611 10.1159/000359984 10.1111/odi.12167 10.2174/1871523014666150514102027 10.3390/nu11040794 10.1097/MPH.0000000000000039 10.1016/j.cgh.2016.05.035 10.1177/0884533616674492 10.1200/JCO.2009.25.8723 10.1126/science.1123933 10.1186/1471-2164-11-26 10.1038/nrc1074 10.1136/bmj.b3692 10.1016/j.juro.2011.07.086 10.3390/biomedicines6040104 10.3390/nu12020579 10.1016/j.clcc.2012.09.003 10.14336/AD.2016.1021 10.1200/JCO.1988.6.10.1653 10.2147/OTT.S60114 10.3390/pharmaceutics11070347 10.1016/j.pbiomolbio.2006.02.016 10.1016/s0960-0760(02)00053-5 10.1371/journal.pone.0195844 10.1097/EJA.0b013e328356676b 10.1056/NEJMoa1500409 10.1210/jc.2011-0385 10.1001/jamaoncol.2016.5917 |
ContentType | Journal Article |
Copyright | 2020 Taylor & Francis Group, LLC 2020 2020 Taylor & Francis Group, LLC |
Copyright_xml | – notice: 2020 Taylor & Francis Group, LLC 2020 – notice: 2020 Taylor & Francis Group, LLC |
DBID | NPM AAYXX CITATION 7U7 C1K 7X8 |
DOI | 10.1080/01635581.2020.1804948 |
DatabaseName | PubMed CrossRef Toxicology Abstracts Environmental Sciences and Pollution Management MEDLINE - Academic |
DatabaseTitle | PubMed CrossRef Toxicology Abstracts Environmental Sciences and Pollution Management MEDLINE - Academic |
DatabaseTitleList | PubMed Toxicology Abstracts |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine Diet & Clinical Nutrition |
EISSN | 1532-7914 |
EndPage | 1696 |
ExternalDocumentID | 10_1080_01635581_2020_1804948 32777949 1804948 |
Genre | Article Journal Article |
GroupedDBID | --- .7I .QK 04C 07V 0BK 0R~ 123 1PE 29N 36B 4.4 5RE 5VS 6PF A8Z AAGZJ AAJNR AALUX AAMIU AAPUL AAQRR AATTQ AAWTL ABBKH ABDBF ABEIZ ABLCE ABPEM ABPTK ABTAI ABUPF ABZLS ACENM ACGFS ACGOD ACKLR ACLSK ACPRK ACTOA ACVOX ADBBV ADCVX ADFCX AECIN AEKEX AEOZL AEPSL AEXWM AFOLD AFRAH AFWLO AGDLA AGFJD AGMYJ AGRBW AGYJP AIJEM AIRBT AJWEG AKBVH ALMA_UNASSIGNED_HOLDINGS ALQZU AMDAE ARJSQ AVBZW AWYRJ BLEHA BMOTO BMSDO BOHLJ BTKSN CCCUG CQ1 CS3 DGFLZ DKSSO EAL EAP EBB EBC EBD EBS EBX ECF ECT ECV EIHBH EMB EMK EMOBN ENC EPL EPT ESX E~B E~C F5P FUNRP G-F GTTXZ H13 HF~ HZ~ IPNFZ J.O KDLKA KRBQP KSSTO KWAYT KYCEM LJTGL M4Z NA5 NZ~ O9- PQEST PQQKQ Q~Q RIG RNANH RVRKI S-F STATR SV3 TFL TFW TNTFI TUS UEQFS UT5 UT9 V1K VAE WQ9 ~01 ~KM ~S~ ABJNI ABLIJ ABXYU ALYBC ESTFP NPM TBQAZ TERGH AAHBH AAYXX ACIEZ ADOJX CITATION TDBHL TUROJ 7U7 C1K 7X8 |
ID | FETCH-LOGICAL-c394t-a0c8dc83f6721b5b2f8b20f66a764e239ac90e1641dfe04e8dc102ff5d2f19633 |
ISSN | 0163-5581 |
IngestDate | Sat Aug 17 00:43:57 EDT 2024 Fri Aug 30 23:59:29 EDT 2024 Fri Aug 23 00:38:36 EDT 2024 Thu May 23 23:41:49 EDT 2024 Tue Jun 13 19:49:57 EDT 2023 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 9 |
Language | English |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c394t-a0c8dc83f6721b5b2f8b20f66a764e239ac90e1641dfe04e8dc102ff5d2f19633 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ORCID | 0000-0001-6624-5893 |
PMID | 32777949 |
PQID | 2562660730 |
PQPubID | 105635 |
PageCount | 10 |
ParticipantIDs | crossref_primary_10_1080_01635581_2020_1804948 proquest_journals_2562660730 informaworld_taylorfrancis_310_1080_01635581_2020_1804948 pubmed_primary_32777949 proquest_miscellaneous_2432857990 |
PublicationCentury | 2000 |
PublicationDate | 2021-00-00 |
PublicationDateYYYYMMDD | 2021-01-01 |
PublicationDate_xml | – year: 2021 text: 2021-00-00 |
PublicationDecade | 2020 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States – name: Mahwah |
PublicationTitle | Nutrition and cancer |
PublicationTitleAlternate | Nutr Cancer |
PublicationYear | 2021 |
Publisher | Taylor & Francis Taylor & Francis Ltd |
Publisher_xml | – name: Taylor & Francis – name: Taylor & Francis Ltd |
References | CIT0030 CIT0010 CIT0032 CIT0031 CIT0012 CIT0034 CIT0011 CIT0033 Takeuti FAC (CIT0009) 2018; 25 CIT0014 CIT0036 CIT0013 CIT0035 CIT0016 CIT0038 CIT0015 CIT0037 CIT0018 CIT0017 CIT0039 CIT0019 CIT0041 CIT0040 CIT0021 CIT0020 CIT0042 CIT0023 CIT0022 Grem JL (CIT0001) 2011 CIT0003 CIT0025 CIT0024 CIT0005 CIT0027 CIT0004 CIT0026 CIT0007 CIT0029 van Groeningen CJ (CIT0002) 1988; 48 CIT0006 CIT0028 CIT0008 |
References_xml | – ident: CIT0006 doi: 10.1016/j.oraloncology.2009.08.006 – ident: CIT0017 doi: 10.1530/ERC-12-0381 – ident: CIT0018 doi: 10.1038/nrc3691 – ident: CIT0040 doi: 10.1016/j.bbamcr.2018.05.015 – volume: 48 start-page: 6956 issue: 23 year: 1988 ident: CIT0002 publication-title: Cancer Res contributor: fullname: van Groeningen CJ – ident: CIT0036 doi: 10.1097/01.JNR.0000347584.00705.b8 – ident: CIT0038 doi: 10.1097/01.MIB.0000436957.77533.b2 – ident: CIT0024 doi: 10.1007/BF02256536 – ident: CIT0028 doi: 10.1038/nri.2017.1 – ident: CIT0033 doi: 10.1056/NEJMra070553 – ident: CIT0004 doi: 10.18632/oncotarget.14371 – ident: CIT0016 doi: 10.3748/wjg.v22.i18.4594 – ident: CIT0023 doi: 10.1146/annurev-pharmtox-010510-100611 – ident: CIT0029 doi: 10.1159/000359984 – ident: CIT0005 doi: 10.1111/odi.12167 – ident: CIT0032 doi: 10.2174/1871523014666150514102027 – volume: 25 start-page: 291 issue: 140 year: 2018 ident: CIT0009 publication-title: Discov Med contributor: fullname: Takeuti FAC – ident: CIT0010 doi: 10.3390/nu11040794 – ident: CIT0031 doi: 10.1097/MPH.0000000000000039 – ident: CIT0039 doi: 10.1016/j.cgh.2016.05.035 – ident: CIT0012 doi: 10.1177/0884533616674492 – ident: CIT0027 doi: 10.1200/JCO.2009.25.8723 – ident: CIT0011 doi: 10.1126/science.1123933 – ident: CIT0021 doi: 10.1186/1471-2164-11-26 – ident: CIT0025 doi: 10.1038/nrc1074 – ident: CIT0034 doi: 10.1136/bmj.b3692 – start-page: 139 volume-title: Cancer chemotherapy and biotherapy: principles and practice year: 2011 ident: CIT0001 contributor: fullname: Grem JL – ident: CIT0041 doi: 10.1016/j.juro.2011.07.086 – ident: CIT0014 doi: 10.3390/biomedicines6040104 – ident: CIT0037 doi: 10.3390/nu12020579 – ident: CIT0026 doi: 10.1016/j.clcc.2012.09.003 – ident: CIT0013 doi: 10.14336/AD.2016.1021 – ident: CIT0003 doi: 10.1200/JCO.1988.6.10.1653 – ident: CIT0022 doi: 10.2147/OTT.S60114 – ident: CIT0008 doi: 10.3390/pharmaceutics11070347 – ident: CIT0007 doi: 10.1016/j.pbiomolbio.2006.02.016 – ident: CIT0015 doi: 10.1016/s0960-0760(02)00053-5 – ident: CIT0042 doi: 10.1371/journal.pone.0195844 – ident: CIT0030 doi: 10.1097/EJA.0b013e328356676b – ident: CIT0019 doi: 10.1056/NEJMoa1500409 – ident: CIT0035 doi: 10.1210/jc.2011-0385 – ident: CIT0020 doi: 10.1001/jamaoncol.2016.5917 |
SSID | ssj0007138 |
Score | 2.377289 |
Snippet | Chemotherapy is a major therapeutic strategy for patients with cancer. Owing to the severe inflammatory response of chemotherapy, patients experience extreme... |
SourceID | proquest crossref pubmed informaworld |
SourceType | Aggregation Database Index Database Publisher |
StartPage | 1687 |
SubjectTerms | 25-Hydroxyvitamin D 5-Fluorouracil Calcitriol Chemotherapy Cytokines Damage Dilution Inflammation Inflammatory response Interleukin 6 Patients Tumor necrosis factor-α Vitamin D3 |
Title | Protective Effect of Calcitriol on Organ Damage Induced by 5-Fluorouracil Treatment |
URI | https://www.tandfonline.com/doi/abs/10.1080/01635581.2020.1804948 https://www.ncbi.nlm.nih.gov/pubmed/32777949 https://www.proquest.com/docview/2562660730/abstract/ https://search.proquest.com/docview/2432857990 |
Volume | 73 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwFLZKJyFeEIxbYCAjIV6Qq8Rxbo9bt2qCtSAtldqnKHFtLVJJoCRI7NdzHDuXauP6ErVOmqT5vpyLfS4IveG2Iza2y0nAQ5-wTWSTLPIYYU19qdAHo1TlDs8X_vmSvV95q9Ho-yBqqa6yCb--Na_kf1CFMcBVZcn-A7LdSWEAPgO-sAWEYftXGH_SRRZU8I-pQqyzrXhe7fJyqxYCmlxLwPazis1RfTq4Njk9MtvW5Q6ukvJ8-y5u482HxuqirdSvk98UP7pQ3qnJ6ri8rsn0Ku-H64Ks9a4PHWfWOZmndaGklPjaT-EXJDYdVdapUaBm_oH2Mw_xjSYgg0ikZq7Sd4nn6Y4sE9HKV6oqZLKhANa9TAzRooE0dXyjjIX5qpvf3pD6JkzSUcZTqJx-CoNhU_mmV3Pt0v7iYzJbXlwk8dkqvoMOaAAe4hgdHJ-cnsw6HQ6ue6irwuu_0OZ-qarst11mz6rZq3n7a8-lsWDiB-i-cT3wsebRQzQSxSGyTnNR4bfY1Ifd4g70Q3R3bgIvHqHLnmpYUw2XEvdUw2WBG6phTTVsqIazH3ifarij2mO0nJ3F03Ni-nEQ7kasIqnNww0PXekH1Mm8jMowo7b0_TTwmaBulPLIFuB_OxspbCbgYDBfpfQ2VCpB7z5B46IsxDOEIxh1pedzsD4Z94KMOQ6XqRNKAfYxDyw0aZ9n8kWXXUmctpqtASBRACQGAAtFw6eeVA05peZl4v7ht0ctRIl5u78l4AqA7aoUoIVed7tB9qoFtbQQZQ3HMJeGXgAGnYWeami7u3VpEICui57__uQv0D31UulJvSM0rna1eAlmbpW9Mpz8Cf2coEI |
link.rule.ids | 315,786,790,4043,27956,27957,27958 |
linkProvider | EBSCOhost |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Protective+Effect+of+Calcitriol+on+Organ+Damage+Induced+by+5-Fluorouracil+Treatment&rft.jtitle=Nutrition+and+cancer&rft.au=Chen%2C+Szu-Chi&rft.au=Chun-Yen%2C+Ke&rft.au=Yi-Maun+Subeq&rft.au=Wan-Ting%2C+Yang&rft.date=2021&rft.pub=Taylor+%26+Francis+Ltd&rft.issn=0163-5581&rft.eissn=1532-7914&rft.volume=73&rft.issue=9&rft.spage=1687&rft.epage=1696&rft_id=info:doi/10.1080%2F01635581.2020.1804948&rft.externalDBID=NO_FULL_TEXT |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0163-5581&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0163-5581&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0163-5581&client=summon |