Phosphatidylinostitol-3 kinase and phospholipase C enhance CSF-1-dependent macrophage survival by controlling glucose uptake

• Published in: Cellular signalling Vol. 21; no. 9; pp. 1361 - 1369
• Main Authors: Chang, Margaret, Hamilton, John A., Scholz, Glen M., Masendycz, Paul, Macaulay, S. Lance, Elsegood, Caryn L.
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.09.2009
• Subjects: Actins - metabolism; Akt; Animals; Bone marrow-derived macrophage; Cell Survival; Colony stimulating factor-1; Glucose - metabolism; Glucose Transporter Type 1 - metabolism; Glucose uptake; Macrophage Colony-Stimulating Factor - pharmacology; Macrophages - drug effects; Macrophages - enzymology; Mice; Mice, Inbred C57BL; Phosphatidylinositol 3-Kinases - metabolism; Phospholipase C; PI3K; Protein kinase C; Protein Kinase C - metabolism; Proto-Oncogene Proteins c-akt - metabolism; Signal Transduction; Survival; Type C Phospholipases - metabolism; Protein kinase C; BMM; PLC; RTK; Colony stimulating factor-1; PKC; Bone marrow-derived macrophage; Akt; CSF-1; Survival; Phospholipase C; Glucose uptake; glut; PI3K; IB; 2DOG

Colony stimulating factor-1 (CSF-1)-dependent macrophages play crucial roles in the development and progression of several pathological conditions including atherosclerosis and breast cancer metastasis. Macrophages in both of these pathologies take up increased amounts of glucose. Since we had previ...