Sympathectomy abrogates immunodeficiency associated with protein-energy malnutrition

• Published in: Journal of neuroimmunology Vol. 99; no. 1; pp. 97 - 104
• Main Authors: González-Ariki, Silvia, Husband, Alan J
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.1999
• Subjects: Animals; Female; IgA+cells ontogeny; Immunoglobulin A - immunology; Immunologic Deficiency Syndromes - etiology; Immunologic Deficiency Syndromes - surgery; Injections, Intraperitoneal; Intestinal Mucosa - immunology; Jejunum - immunology; Lactation; lamina propria; Malnutrition; Models, Immunological; Mucosal immunology; Neuroimmunomodulation; ovalbumin; Ovalbumin - immunology; Oxidopamine - therapeutic use; Pregnancy; Pregnancy Complications; Prenatal Exposure Delayed Effects; Protein-Energy Malnutrition - complications; Protein-Energy Malnutrition - immunology; Rats; sympathectomy; Sympathectomy, Chemical; Sympathetic innervation; Sympathetic Nervous System - physiopathology; Mucosal immunology; AOCC, anti-OVA-containing cells; NA, noradrenaline; PP, Peyer's patch; IgA+cells ontogeny; GALT, gut associated lymphoid tissues; 6-OHDA, 6-hydroxydopamine; Sympathetic innervation; MN, malnourished; OVA, ovalbumin; LPD, low protein diet; WN, well nourished; Malnutrition; PEM, protein energy malnutrition

The role of the sympathetic nervous system in the immune deficiency developed in protein-energy malnutrition (PEM) was investigated by assessing the effects of sympathectomy on the intestinal immune response of rats subject to prenatal or postnatal malnutrition. Chemical sympathectomy increased the...