Circulating Adhesion Molecules VCAM-1, ICAM-1, and E-selectin in Carotid Atherosclerosis and Incident Coronary Heart Disease Cases The Atherosclerosis Risk In Communities (ARIC) Study

• Published in: Circulation (New York, N.Y.) Vol. 96; no. 12; pp. 4219 - 4225
• Main Authors: Hwang, Shih-Jen, Ballantyne, Christie M., Sharrett, A. Richey, Smith, Louis C., Davis, Clarence E., Gotto, Antonio M., Boerwinkle, Eric
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 16.12.1997; American Heart Association, Inc
• Subjects: African Continental Ancestry Group; Arteriosclerosis - blood; Arteriosclerosis - diagnostic imaging; Arteriosclerosis - ethnology; Atherosclerosis (general aspects, experimental research); Biological and medical sciences; Biomarkers; Blood and lymphatic vessels; Cardiology. Vascular system; Carotid Artery Diseases - blood; Carotid Artery Diseases - diagnostic imaging; Carotid Artery Diseases - ethnology; Cohort Studies; Coronary Disease - blood; Coronary Disease - diagnostic imaging; E-Selectin - blood; European Continental Ancestry Group; Female; Forecasting; Humans; Intercellular Adhesion Molecule-1 - blood; Male; Medical sciences; Middle Aged; Regression Analysis; Risk Factors; Ultrasonography; Vascular Cell Adhesion Molecule-1 - blood; Vascular disease; Human; Vascular cell adhesion molecule 1; Intercellular adhesion molecule 1; E Selectin; Carotid; Atherosclerosis; Risk factor; Biological marker; Cardiovascular disease; Adhesion; Coronary heart disease

Background Recruitment of circulating leukocytes at sites of atherosclerosis is mediated through a family of adhesion molecules. The function of circulating forms of these adhesion molecules remains unknown, but their levels may serve as molecular markers of subclinical coronary heart disease (CHD)....