Kinetics of Pancreatic Exocrine Secretion and Plasma Gut Regulatory Peptide Release in Response to Feeding in Preruminant and Ruminant Calves

• Published in: Comparative biochemistry and physiology. A, Comparative physiology Vol. 117; no. 2; pp. 245 - 255
• Main Authors: Le Dréan, G, Le Huërou-Luron, I, Chayvialle, J.A, Philouze-Romé, V, Gestin, M, Bernard, C, Toullec, R, Guilloteau, P
• Format: Journal Article
• Language: English
• Published: United States Elsevier B.V 01.06.1997; Elsevier
• Subjects: Animals; Animals, Suckling; Biochemistry, Molecular Biology; Calf; Cattle; Eating - physiology; feeding; Gastrins - secretion; Gastrointestinal Hormones - blood; Gastrointestinal Hormones - secretion; gut regulatory peptides; Kinetics; Life Sciences; Male; milk-fed; Pancreas - secretion; pancreatic exocrine secretion; Pancreatic Juice - secretion; Proteins - secretion; ruminant; Secretin - secretion; Sincalide - secretion; Somatostatin - secretion; Trypsin - secretion; milk-fed; ruminant; pancreatic exocrine secretion; gut regulatory peptides; Calf; feeding
• ISSN: 0300-9629; 1096-4940; 1879-1115
• DOI: 10.1016/S0300-9629(96)00257-5

Pancreatic exocrine secretion and plasma cholecystokinin, gastrin, secretin, and somatostatin concentrations were examined in relation to feeding in 70- to 120-day-old preruminant and ruminant calves. The apparatus used was designed to immediately re-infuse the animal's own pancreatic juice and to carry out accurate measurements of the juice flow in real time and to take samples. In the preruminants, pancreatic juice, protein, and trypsin flows increased from 45 min before and until 15 min after the meal and decreased sharply thereafter over a period of 30 min, while protein and trypsin concentrations peaked after feeding. A significant increase in plasma gastrin and cholecystokinin (CCK), a fall in secretin and no change in somatostatin were observed after milk ingestion. By contrast, in the ruminants, feeding had no effect on the pancreatic secretion and on the plasma concentrations of these peptides. Similar and simultaneous patterns of juice flow and secretin, as well as of protein and trypsin concentrations, CCK and gastrin, could support the hypothesis that these gut regulatory peptides play a significant role in the regulation of the pancreatic function. In preruminant calves, the existence of cephalic, gastric and intestinal phases is discussed. In the ruminants, that of the ruminal phase is questionable.