Occupational exposure to graphene and silica nanoparticles. Part II: pilot study to identify a panel of sensitive biomarkers of genotoxic, oxidative and inflammatory effects on suitable biological matrices

• Published in: Nanotoxicology Vol. 15; no. 2; pp. 223 - 237
• Main Authors: Ursini, Cinzia Lucia, Fresegna, Anna Maria, Ciervo, Aureliano, Maiello, Raffaele, Del Frate, Valentina, Folesani, Giuseppina, Galetti, Maricla, Poli, Diana, Buresti, Giuliana, Di Cristo, Luisana, Sabella, Stefania, Iavicoli, Sergio, Cavallo, Delia
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.03.2021; Taylor & Francis Ltd
• Subjects: Adult; Bioassays; Biological effects; Biomarkers; Biomarkers - metabolism; Biomonitoring; Buccal micronucleus cytome assay; Cells, Cultured; Comet Assay; Cytokines; Cytokines - metabolism; DNA Damage; Exhaled breath condensate (EBC); Exposure; Female; FPG-comet assay; Genotoxicity; Graphene; Graphite - administration & dosage; Graphite - toxicity; Humans; Inflammation; Lymphocytes; Male; Micronucleus Tests; Mouth Mucosa - cytology; Mouth Mucosa - drug effects; Mouth Mucosa - metabolism; Nanomaterials; Nanoparticles; Nanoparticles - administration & dosage; Nanoparticles - toxicity; Nanotechnology; Occupational exposure; Occupational Exposure - adverse effects; Occupational Exposure - analysis; Occupational health; Oxidation-Reduction; Oxidative stress; Oxidative Stress - drug effects; Oxidative Stress - genetics; Oxidative Stress - immunology; Pilot Projects; Silica; silica nanoparticles; Silicon dioxide; Silicon Dioxide - administration & dosage; Silicon Dioxide - toxicity; Vascular system; Workplace - standards; Buccal micronucleus cytome assay; FPG-comet assay; silica nanoparticles; graphene; Exhaled breath condensate (EBC)

The available biomonitoring studies on workers producing/handling nanomaterials (NMs) focused on potential effects on respiratory, immune and cardio-vascular system. Aim of this study was to identify a panel of sensitive biomarkers and suitable biological matrices to evaluate particularly genotoxic...