The Transcription Factor AP-2β Causes Cell Enlargement and Insulin Resistance in 3T3-L1 Adipocytes

• Published in: Endocrinology (Philadelphia) Vol. 147; no. 4; pp. 1685 - 1696
• Main Authors: Tao, Yukari, Maegawa, Hiroshi, Ugi, Satoshi, Ikeda, Kazuhiro, Nagai, Yoshio, Egawa, Katsuya, Nakamura, Takaaki, Tsukada, Shuichi, Nishio, Yoshihiko, Maeda, Shiro, Kashiwagi, Atsunori
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Endocrine Society 01.04.2006; Oxford University Press
• Subjects: 1-Phosphatidylinositol 3-kinase; Adipocytes; Adipose tissue; Alleles; Biological and medical sciences; Cell size; Diabetes; Diabetes mellitus (non-insulin dependent); Enzyme inhibitors; Fundamental and applied biological sciences. Psychology; Gene expression; Glucose; Grb2 protein; Hypertrophy; Insulin; Insulin resistance; Kinases; Pathogenesis; Phospholipase C; Phosphorylation; Protein kinase C; Proteins; Resistance factors; siRNA; Transcription factors; Triglycerides; Tyrosine; Vertebrates: endocrinology; Transcription factor; Adipocyte; Insulin resistance

We have reported the association of variations in the activating protein-2β (AP-2β) transcription factor gene with type 2 diabetes. This gene was preferentially expressed in 3T3-L1 adipocytes in a differentiation stage-dependent manner, and preliminary experiments showed that subjects with the disea...