Metabolism of the chemopreventive retinoid N-(4-hydroxyphenyl)retinamide by mammary gland in organ culture

• Published in: Biochemical journal Vol. 256; no. 2; pp. 579 - 584
• Main Authors: Mehta, R.G, Hultin, T.A, Moon, R.C
• Format: Journal Article
• Language: English
• Published: England 01.12.1988
• Subjects: Animals; binding sites; Binding, Competitive; carcinogenesis; Carrier Proteins - metabolism; culture media; Female; Fenretinide; Hormones - pharmacology; mammary glands; Mammary Glands, Animal - drug effects; Mammary Glands, Animal - metabolism; Mice; Mice, Inbred BALB C; Organ Culture Techniques; prevention; Receptors, Retinoic Acid; retinoids; Time Factors; Tretinoin - analogs & derivatives; Tretinoin - metabolism

N-(4-Hydroxyphenyl)retinamide (4-HPR) is considered to be the most effective chemopreventive retinoid for chemically induced mammary carcinogenesis in rats. However, the mechanism of 4-HPR action in mammary cells is poorly understood. In the present study we examined the metabolism of 4-HPR in the m...