Met receptor is essential for MAVS-mediated antiviral innate immunity in epithelial cells independent of its kinase activity

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 120; no. 40; p. e2307318120
• Main Authors: Imamura, Ryu, Sato, Hiroki, Chih-Cheng Voon, Dominic, Shirasaki, Takayoshi, Honda, Masao, Kurachi, Makoto, Sakai, Katsuya, Matsumoto, Kunio
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 03.10.2023
• Series: Brief Report
• Subjects: Biological Sciences; Cytokines; Epithelial Cells; Immunity, Innate; Receptor Protein-Tyrosine Kinases; RIG-I; MAVS; inflammatory cytokine; met receptor; RNA virus

Epithelial tissue is at the forefront of innate immunity, playing a crucial role in the recognition and elimination of pathogens. Met is a receptor tyrosine kinase that is necessary for epithelial cell survival, proliferation, and regeneration. Here, we showed that Met is essential for the induction...