Investigate the role of PTEN in chemotaxis of human breast cancer cells

• Published in: Cellular signalling Vol. 19; no. 11; pp. 2227 - 2236
• Main Authors: Wan, Wuzhou, Zou, Haixia, Sun, Ronghua, Liu, Ying, Wang, Jingna, Ma, Dalong, Zhang, Ning
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.11.2007
• Subjects: Adhesion; Animals; Breast cancer; Breast Neoplasms - enzymology; Breast Neoplasms - pathology; Cell Adhesion - drug effects; Cell Line, Tumor; Cell Membrane - drug effects; Chemotaxis; Chemotaxis - drug effects; EGFR; Epidermal Growth Factor - pharmacology; Gene Expression - drug effects; Humans; Lung Neoplasms - secondary; Metastasis; Mice; Mice, SCID; Neoplasm Metastasis; PTEN; PTEN Phosphohydrolase - metabolism; RNA, Small Interfering - metabolism; Signal Transduction - drug effects; PTEN; Breast cancer; Metastasis; Chemotaxis; Adhesion; EGFR

Chemotaxis plays an important role in metastasis of cancer cells. In the current study, we investigated the role of PTEN, a tumor suppressor, in chemotaxis of human breast cancer cells. Over-expression of PTEN inhibited EGF-induced chemotaxis, probably due to an overall reduction of PIP3 levels. Dis...