Predictive Value of Electron Beam Computed Tomography of the Coronary Arteries 19-Month Follow-up of 1173 Asymptomatic Subjects
Background Coronary electron beam computed tomography (EBCT) detects atherosclerotic coronary artery disease by measuring calcium deposition in the walls of coronary arteries. EBCT-derived coronary artery calcium (CAC) scores correlate with the severity of underlying coronary artery disease. Methods...
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| Published in | Circulation (New York, N.Y.) Vol. 93; no. 11; pp. 1951 - 1953 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Hagerstown, MD
Lippincott Williams & Wilkins
01.06.1996
American Heart Association, Inc |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Background
Coronary electron beam computed tomography (EBCT) detects atherosclerotic coronary artery disease by measuring calcium deposition in the walls of coronary arteries. EBCT-derived coronary artery calcium (CAC) scores correlate with the severity of underlying coronary artery disease.
Methods and Results
We followed 1173 asymptomatic patients who underwent EBCT between September 1993 and March 1994. During average follow-up of 19 months, 18 subjects had 26 cardiovascular events: 1 death, 7 myocardial infarctions, 8 coronary artery bypass graft procedures, 9 coronary angioplasties, and 1 nonhemorrhagic stroke. For CAC score thresholds of 100, 160, and 680, EBCT had sensitivities of 89%, 89%, and 50% and specificities of 77%, 82%, and 95%, respectively. Odds ratios ranged from 20.0 to 35.4 (
P
<.00001 for all).
Conclusions
Coronary EBCT predicts future atherosclerotic cardiovascular disease events in asymptomatic subjects. |
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| AbstractList | Coronary electron beam computed tomography (EBCT) detects atherosclerotic coronary artery disease by measuring calcium deposition in the walls of coronary arteries. EBCT-derived coronary artery calcium (CAC) scores correlate with the severity of underlying coronary artery disease.
We followed 1173 asymptomatic patients who underwent EBCT between September 1993 and March 1994. During average follow-up of 19 months, 18 subjects had 26 cardiovascular events: 1 death, 7 myocardial infarctions, 8 coronary artery bypass graft procedures, 9 coronary angioplasties, and 1 nonhemorrhagic stroke. For CAC score thresholds of 100, 160, and 680, EBCT had sensitivities of 89%, 89%, and 50% and specificities of 77%, 82%, and 95%, respectively. Odds ratios ranged from 20.0 to 35.4 (P < .0001 for all).
Coronary EBCT predicts future atherosclerotic cardiovascular disease events in asymptomatic subjects. Coronary electron beam computed tomography (EBCT) detects atherosclerotic coronary artery disease by measuring calcium deposition in the walls of coronary arteries. EBCT-derived coronary artery calcium (CAC) scores correlate with the severity of underlying coronary artery disease.BACKGROUNDCoronary electron beam computed tomography (EBCT) detects atherosclerotic coronary artery disease by measuring calcium deposition in the walls of coronary arteries. EBCT-derived coronary artery calcium (CAC) scores correlate with the severity of underlying coronary artery disease.We followed 1173 asymptomatic patients who underwent EBCT between September 1993 and March 1994. During average follow-up of 19 months, 18 subjects had 26 cardiovascular events: 1 death, 7 myocardial infarctions, 8 coronary artery bypass graft procedures, 9 coronary angioplasties, and 1 nonhemorrhagic stroke. For CAC score thresholds of 100, 160, and 680, EBCT had sensitivities of 89%, 89%, and 50% and specificities of 77%, 82%, and 95%, respectively. Odds ratios ranged from 20.0 to 35.4 (P < .0001 for all).METHODS AND RESULTSWe followed 1173 asymptomatic patients who underwent EBCT between September 1993 and March 1994. During average follow-up of 19 months, 18 subjects had 26 cardiovascular events: 1 death, 7 myocardial infarctions, 8 coronary artery bypass graft procedures, 9 coronary angioplasties, and 1 nonhemorrhagic stroke. For CAC score thresholds of 100, 160, and 680, EBCT had sensitivities of 89%, 89%, and 50% and specificities of 77%, 82%, and 95%, respectively. Odds ratios ranged from 20.0 to 35.4 (P < .0001 for all).Coronary EBCT predicts future atherosclerotic cardiovascular disease events in asymptomatic subjects.CONCLUSIONSCoronary EBCT predicts future atherosclerotic cardiovascular disease events in asymptomatic subjects. Background Coronary electron beam computed tomography (EBCT) detects atherosclerotic coronary artery disease by measuring calcium deposition in the walls of coronary arteries. EBCT-derived coronary artery calcium (CAC) scores correlate with the severity of underlying coronary artery disease. Methods and Results We followed 1173 asymptomatic patients who underwent EBCT between September 1993 and March 1994. During average follow-up of 19 months, 18 subjects had 26 cardiovascular events: 1 death, 7 myocardial infarctions, 8 coronary artery bypass graft procedures, 9 coronary angioplasties, and 1 nonhemorrhagic stroke. For CAC score thresholds of 100, 160, and 680, EBCT had sensitivities of 89%, 89%, and 50% and specificities of 77%, 82%, and 95%, respectively. Odds ratios ranged from 20.0 to 35.4 ( P <.00001 for all). Conclusions Coronary EBCT predicts future atherosclerotic cardiovascular disease events in asymptomatic subjects. |
| Author | Sherman, Scott Spadaro, Louise A. Arad, Yadon Lerner, Gail Lledo-Perez, Alfonso Guerci, Alan D. Goodman, Ken |
| Author_xml | – sequence: 1 givenname: Yadon surname: Arad fullname: Arad, Yadon organization: From the Departments of Preventive Cardiology (Y.A., L.A.S., G.L., A.D.G.) and Radiology (K.G., A.L., S.S.), St Francis Hospital, Roslyn, NY – sequence: 2 givenname: Louise A. surname: Spadaro fullname: Spadaro, Louise A. organization: From the Departments of Preventive Cardiology (Y.A., L.A.S., G.L., A.D.G.) and Radiology (K.G., A.L., S.S.), St Francis Hospital, Roslyn, NY – sequence: 3 givenname: Ken surname: Goodman fullname: Goodman, Ken organization: From the Departments of Preventive Cardiology (Y.A., L.A.S., G.L., A.D.G.) and Radiology (K.G., A.L., S.S.), St Francis Hospital, Roslyn, NY – sequence: 4 givenname: Alfonso surname: Lledo-Perez fullname: Lledo-Perez, Alfonso organization: From the Departments of Preventive Cardiology (Y.A., L.A.S., G.L., A.D.G.) and Radiology (K.G., A.L., S.S.), St Francis Hospital, Roslyn, NY – sequence: 5 givenname: Scott surname: Sherman fullname: Sherman, Scott organization: From the Departments of Preventive Cardiology (Y.A., L.A.S., G.L., A.D.G.) and Radiology (K.G., A.L., S.S.), St Francis Hospital, Roslyn, NY – sequence: 6 givenname: Gail surname: Lerner fullname: Lerner, Gail organization: From the Departments of Preventive Cardiology (Y.A., L.A.S., G.L., A.D.G.) and Radiology (K.G., A.L., S.S.), St Francis Hospital, Roslyn, NY – sequence: 7 givenname: Alan D. surname: Guerci fullname: Guerci, Alan D. organization: From the Departments of Preventive Cardiology (Y.A., L.A.S., G.L., A.D.G.) and Radiology (K.G., A.L., S.S.), St Francis Hospital, Roslyn, NY |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3099199$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/8640967$$D View this record in MEDLINE/PubMed |
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| CODEN | CIRCAZ |
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| Cites_doi | 10.1016/0735-1097(95)00314-2 10.1016/0735-1097(94)00435-S 10.2307/3348873 10.1001/jama.1995.03530100041032 10.1148/radiology.192.3.8058924 10.1016/0735-1097(94)90287-9 10.1161/circ.92.8.2157 10.1161/circ.93.5.898 10.1161/circ.32.6.948 10.1016/0735-1097(90)90282-T 10.1016/S0735-1097(86)80208-X |
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| References | (e_1_3_2_4_2) 1959; 81 e_1_3_2_9_2 e_1_3_2_15_2 e_1_3_2_16_2 e_1_3_2_7_2 e_1_3_2_17_2 e_1_3_2_6_2 e_1_3_2_18_2 e_1_3_2_19_2 e_1_3_2_1_2 (e_1_3_2_5_2) 1964; 92 e_1_3_2_20_2 (e_1_3_2_8_2) 1995; 9 e_1_3_2_10_2 e_1_3_2_11_2 e_1_3_2_12_2 e_1_3_2_3_2 e_1_3_2_2_2 e_1_3_2_14_2 (e_1_3_2_13_2) 1995; 9 9008478 - Circulation. 1997 Jan 21;95(2):534-5; author reply 535-6 9008477 - Circulation. 1997 Jan 21;95(2):534; author reply 535-6 |
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Coronary electron beam computed tomography (EBCT) detects atherosclerotic coronary artery disease by measuring calcium deposition in the walls of... Coronary electron beam computed tomography (EBCT) detects atherosclerotic coronary artery disease by measuring calcium deposition in the walls of coronary... |
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| SubjectTerms | Angioplasty - statistics & numerical data Biological and medical sciences Brain Ischemia - epidemiology Calcinosis - diagnostic imaging Calcium - analysis Cardiovascular system Coronary Angiography - methods Coronary Artery Bypass - statistics & numerical data Coronary Artery Disease - complications Coronary Artery Disease - diagnostic imaging Coronary Vessels - chemistry Coronary Vessels - pathology Death, Sudden, Cardiac - epidemiology Death, Sudden, Cardiac - etiology Disease Progression Female Follow-Up Studies Humans Investigative techniques, diagnostic techniques (general aspects) Male Mass Screening Medical sciences Myocardial Infarction - epidemiology Myocardial Infarction - etiology Myocardial Infarction - prevention & control Radiodiagnosis. Nmr imagery. Nmr spectrometry ROC Curve Sensitivity and Specificity |
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| Title | Predictive Value of Electron Beam Computed Tomography of the Coronary Arteries |
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