Human papillomavirus 68 prevalence and genetic variability based on E6/E7 genes in Sichuan

• Published in: Virology (New York, N.Y.) Vol. 567; pp. 15 - 25
• Main Authors: He, Jiaoyu, Li, Qiufu, Hu, changhua, Peng, Jianying, Ma, Shiyu, Song, Zhilin, Liu, Yiran, Cui, Yanru, Deng, Junhang, Wei, Xia, Ding, Xianping
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2022
• Subjects: Alphapapillomavirus - chemistry; Alphapapillomavirus - classification; Alphapapillomavirus - genetics; Alphapapillomavirus - immunology; Amino Acid Sequence; Amino Acid Substitution; amino acids; B-Lymphocytes - immunology; B-Lymphocytes - virology; Binding Sites; Cervix Uteri - immunology; Cervix Uteri - virology; China; China - epidemiology; chronic diseases; E6/E7; Epitopes; Epitopes - chemistry; Epitopes - genetics; Epitopes - immunology; Female; Genetic variability; genetic variation; Genotype; Histocompatibility Antigens Class I - chemistry; Histocompatibility Antigens Class I - genetics; Histocompatibility Antigens Class I - immunology; HPV68; Humans; Models, Molecular; Molecular Typing; Mutation; Oncogene Proteins, Viral - chemistry; Oncogene Proteins, Viral - genetics; Oncogene Proteins, Viral - immunology; Papillomavirus E7 Proteins - chemistry; Papillomavirus E7 Proteins - genetics; Papillomavirus E7 Proteins - immunology; Papillomavirus Infections - epidemiology; Papillomavirus Infections - immunology; Papillomavirus Infections - virology; pathogenicity; Phylogeny; Prevalence; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; protein structure; Protein Structure, Tertiary; Selection pressure; Sequence Alignment; Sequence Homology, Amino Acid; Structure; T-Lymphocytes - immunology; T-Lymphocytes - virology; uterine cervical neoplasms; virology; China; Selection pressure; Genetic variability; Epitopes; HPV68; Structure; E6/E7

HPV68 is a common HR-HPV, its persistent infection is closely related with the occurrence of cervical cancer. In this study, 2939 (27.60%, 2939/10650) positive samples were detected, and 174 (5.92%, 174/2939) were HPV68. 150 HPV68 E6-E7 were successful sequenced, 4 non-synonymous mutations were dete...