Power priors with entropy balancing weights in data augmentation of partially controlled randomized trials

• Published in: Journal of biopharmaceutical statistics Vol. 32; no. 1; pp. 4 - 20
• Main Authors: Yu, Guanglei, Bian, Yuanyuan, Gamalo, Margaret
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 02.01.2022; Taylor & Francis Ltd
• Subjects: asymmetrical randomization; Bayesian-augmented control; Child; Entropy; entropy balancing; Humans; power prior; Propensity Score; Randomized Controlled Trials as Topic; Research Design; Sample Size; Bayesian-augmented control; entropy balancing; power prior; asymmetrical randomization

In pediatric or orphan diseases, there are many instances where it is unfeasible to conduct randomized and controlled clinical trials. This is due in part to the difficulty of enrolling a sufficient number of patients over a reasonable time period to meet adequate statistical power to demonstrate th...