A proof-of-concept study of coupled supercritical CO2-assisted processes to produce solid self-assembled drug delivery systems (S-SADDS)

• Published in: Journal of crystal growth Vol. 616; p. 127245
• Main Authors: Massias, Thibault, de Paiva Lacerda, Suênia, Resende de Azevedo, Jacqueline, Letourneau, Jean-Jacques, Dos Santos, Philomène, Bolzinger, Marie-Alexandrine, Espitalier, Fabienne
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 15.08.2023; Elsevier
• Subjects: A1. Crystal morphology; A1. Recrystallization; B1. Nanomaterials; B1. Solid self-assembled drug delivery system; B3. RESS/SAS process; B3. Supercritical carbon dioxide process; Engineering Sciences; SAS; CO2; XRPD; EtOH; PVP; A1. Recrystallization; SD; B3. RESS/SAS process; PDI; SLN; S-SADDS; DSC; FTIR; B1. Nanomaterials; DSL; B3. Supercritical carbon dioxide process; NIF; VA; RESS/SAS; PC; scCO2; B1. Solid self-assembled drug delivery system; RESS; SADDS; SEM; A1. Crystal morphology; Nanomaterials; Solid self-assembled drug delivery system; RESS/SAS process; Crystal morphology; Supercritical carbon dioxide process; Recrystallization

•Optimization of solvent injection process to produce Solid Lipid Nanoparticles (SLN)•SLN were transposed to solid self-assembled drug delivery systems (S-SADDS)•Proof of concept of designing a coupled RESS/SAS supercritical CO2 process.•Simultaneous crystallization by innovative RESS/SAS successful...