Effect of SFRP5 (Secreted Frizzled–Related Protein 5) on the WNT5A (Wingless-Type Family Member 5A)-Induced Endothelial Dysfunction and Its Relevance With Arterial Stiffness in Human Subjects

• Published in: Arteriosclerosis, thrombosis, and vascular biology Vol. 38; no. 6; pp. 1358 - 1367
• Main Authors: Cho, Yun Kyung, Kang, Yu Mi, Lee, Seung Eun, Lee, Yoo La, Seol, So Mi, Lee, Woo Je, Park, Joong-Yeol, Jung, Chang Hee
• Format: Journal Article
• Language: English
• Published: United States American Heart Association, Inc 01.06.2018
• Subjects: atherosclerosis; endothelium; nitric oxide; pulse wave velocity; phosphorylation

OBJECTIVE—SFRP5 (secreted frizzled–related protein 5) is an endogenous inhibitor of WNT5A (wingless-type family member 5a), which has been implicated in atherosclerosis. However, contradictory results have been reported about the role of SFRP5 in atherosclerosis. We aimed to investigate whether SFRP...