Composite Colloidal Gels Made of Bisphosphonate‐Functionalized Gelatin and Bioactive Glass Particles for Regeneration of Osteoporotic Bone Defects

• Published in: Advanced functional materials Vol. 27; no. 45
• Main Authors: Diba, Mani, Camargo, Winston A., Brindisi, Mariateresa, Farbod, Kambiz, Klymov, Alexey, Schmidt, Stephan, Harrington, Matthew J., Draghi, Lorenza, Boccaccini, Aldo R., Jansen, John A., van den Beucken, Jeroen J. J. P., Leeuwenburgh, Sander C. G.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc 01.12.2017
• Subjects: Biocompatibility; Biological activity; biomedical applications; Biomedical materials; Colloids; composite materials; Defects; Gels; hydrogels; Implantation; Materials science; Particulate composites; Regeneration; self‐healing; Surgical implants

Injectable composite colloidal gels are developed for regeneration of osteoporotic bone defects through a bottom‐up assembly from bisphosphonate‐functionalized gelatin and bioactive glass particles. Upon bisphosphonate functionalization, gelatin nanoparticles show superior adhesion toward bioactive...