Composite Colloidal Gels Made of Bisphosphonate‐Functionalized Gelatin and Bioactive Glass Particles for Regeneration of Osteoporotic Bone Defects
Injectable composite colloidal gels are developed for regeneration of osteoporotic bone defects through a bottom‐up assembly from bisphosphonate‐functionalized gelatin and bioactive glass particles. Upon bisphosphonate functionalization, gelatin nanoparticles show superior adhesion toward bioactive...
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| Published in | Advanced functional materials Vol. 27; no. 45 |
|---|---|
| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Hoboken
Wiley Subscription Services, Inc
01.12.2017
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Injectable composite colloidal gels are developed for regeneration of osteoporotic bone defects through a bottom‐up assembly from bisphosphonate‐functionalized gelatin and bioactive glass particles. Upon bisphosphonate functionalization, gelatin nanoparticles show superior adhesion toward bioactive glass particles, resulting in elastic composite gels. By tuning their composition, these composite colloidal gels combine mechanical robustness with self‐healing ability. The composite colloidal gels support cell proliferation and differentiation in vitro without requiring any osteogenic supplement. In vivo evaluation of the composite colloidal gels reveals their capacity to support the regeneration of osteoporotic bone defects. Furthermore, the bisphosphonate modification of gelatin induces a therapeutic effect on the peri‐implantation region by enhancing the bone density of the osteoporotic bone tissue. Consequently, these composite colloidal gels offer new therapeutic opportunities for treatment of osteoporotic bone defects.
Injectable composite colloidal gels are developed via bottom‐up assembly from bisphosphonate‐functionalized gelatin and bioactive glass particles. These composite gels combine mechanical robustness with self‐healing ability, and stimulate cellular activities in vitro. Moreover, these materials exhibit a strong capacity to support the regeneration of osteoporotic bone defects, and also induce a therapeutic effect on peridefect osteoporotic bone in vivo. |
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| AbstractList | Injectable composite colloidal gels are developed for regeneration of osteoporotic bone defects through a bottom-up assembly from bisphosphonate-functionalized gelatin and bioactive glass particles. Upon bisphosphonate functionalization, gelatin nanoparticles show superior adhesion toward bioactive glass particles, resulting in elastic composite gels. By tuning their composition, these composite colloidal gels combine mechanical robustness with self-healing ability. The composite colloidal gels support cell proliferation and differentiation in vitro without requiring any osteogenic supplement. In vivo evaluation of the composite colloidal gels reveals their capacity to support the regeneration of osteoporotic bone defects. Furthermore, the bisphosphonate modification of gelatin induces a therapeutic effect on the peri-implantation region by enhancing the bone density of the osteoporotic bone tissue. Consequently, these composite colloidal gels offer new therapeutic opportunities for treatment of osteoporotic bone defects. Injectable composite colloidal gels are developed for regeneration of osteoporotic bone defects through a bottom‐up assembly from bisphosphonate‐functionalized gelatin and bioactive glass particles. Upon bisphosphonate functionalization, gelatin nanoparticles show superior adhesion toward bioactive glass particles, resulting in elastic composite gels. By tuning their composition, these composite colloidal gels combine mechanical robustness with self‐healing ability. The composite colloidal gels support cell proliferation and differentiation in vitro without requiring any osteogenic supplement. In vivo evaluation of the composite colloidal gels reveals their capacity to support the regeneration of osteoporotic bone defects. Furthermore, the bisphosphonate modification of gelatin induces a therapeutic effect on the peri‐implantation region by enhancing the bone density of the osteoporotic bone tissue. Consequently, these composite colloidal gels offer new therapeutic opportunities for treatment of osteoporotic bone defects. Injectable composite colloidal gels are developed via bottom‐up assembly from bisphosphonate‐functionalized gelatin and bioactive glass particles. These composite gels combine mechanical robustness with self‐healing ability, and stimulate cellular activities in vitro. Moreover, these materials exhibit a strong capacity to support the regeneration of osteoporotic bone defects, and also induce a therapeutic effect on peridefect osteoporotic bone in vivo. |
| Author | Camargo, Winston A. Klymov, Alexey Draghi, Lorenza Farbod, Kambiz Schmidt, Stephan van den Beucken, Jeroen J. J. P. Leeuwenburgh, Sander C. G. Diba, Mani Harrington, Matthew J. Boccaccini, Aldo R. Brindisi, Mariateresa Jansen, John A. |
| Author_xml | – sequence: 1 givenname: Mani surname: Diba fullname: Diba, Mani organization: Radboud University Medical Center – sequence: 2 givenname: Winston A. surname: Camargo fullname: Camargo, Winston A. organization: Radboud University Medical Center – sequence: 3 givenname: Mariateresa surname: Brindisi fullname: Brindisi, Mariateresa organization: Politecnico di Milano – sequence: 4 givenname: Kambiz surname: Farbod fullname: Farbod, Kambiz organization: Radboud University Medical Center – sequence: 5 givenname: Alexey surname: Klymov fullname: Klymov, Alexey organization: Radboud University Medical Center – sequence: 6 givenname: Stephan surname: Schmidt fullname: Schmidt, Stephan organization: Heinrich‐Heine‐University Düsseldorf – sequence: 7 givenname: Matthew J. surname: Harrington fullname: Harrington, Matthew J. organization: Max Planck Institute for Colloids and Interfaces – sequence: 8 givenname: Lorenza surname: Draghi fullname: Draghi, Lorenza organization: Politecnico di Milano – sequence: 9 givenname: Aldo R. surname: Boccaccini fullname: Boccaccini, Aldo R. organization: University of Erlangen–Nuremberg – sequence: 10 givenname: John A. surname: Jansen fullname: Jansen, John A. organization: Radboud University Medical Center – sequence: 11 givenname: Jeroen J. J. P. surname: van den Beucken fullname: van den Beucken, Jeroen J. J. P. organization: Radboud University Medical Center – sequence: 12 givenname: Sander C. G. surname: Leeuwenburgh fullname: Leeuwenburgh, Sander C. G. email: sander.leeuwenburgh@radboudumc.nl organization: Radboud University Medical Center |
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| Snippet | Injectable composite colloidal gels are developed for regeneration of osteoporotic bone defects through a bottom‐up assembly from bisphosphonate‐functionalized... Injectable composite colloidal gels are developed for regeneration of osteoporotic bone defects through a bottom-up assembly from bisphosphonate-functionalized... |
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| SubjectTerms | Biocompatibility Biological activity biomedical applications Biomedical materials Colloids composite materials Defects Gels hydrogels Implantation Materials science Particulate composites Regeneration self‐healing Surgical implants |
| Title | Composite Colloidal Gels Made of Bisphosphonate‐Functionalized Gelatin and Bioactive Glass Particles for Regeneration of Osteoporotic Bone Defects |
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