Elucidating dynamic cell lineages and gene networks in time-course single cell differentiation

• Published in: Artificial intelligence in the life sciences Vol. 3; p. 100068
• Main Authors: Zhang, Mengrui, Chen, Yongkai, Yu, Dingyi, Zhong, Wenxuan, Zhang, Jingyi, Ma, Ping
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2023; Elsevier
• Subjects: Dynamic Gene Networks; Optimal Transport; scRNA-seq; Smoothing Spline; scRNA-seq; Smoothing Spline; Optimal Transport; Dynamic Gene Networks

Single cell RNA sequencing (scRNA-seq) technologies provide researchers with an unprecedented opportunity to exploit cell heterogeneity. For example, the sequenced cells belong to various cell lineages, which may have different cell fates in stem and progenitor cells. Those cells may differentiate i...