Transgenerational and intergenerational epigenetic inheritance in allergic diseases

• Published in: Journal of allergy and clinical immunology Vol. 142; no. 3; pp. 765 - 772
• Main Authors: Mørkve Knudsen, Toril, Rezwan, Faisal I., Jiang, Yu, Karmaus, Wilfried, Svanes, Cecilie, Holloway, John W.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2018; Elsevier Limited
• Subjects: Allergic diseases; Allergies; allergy; Animal models; Animals; Asthma; Cell division; Deoxyribonucleic acid; Disease; DNA; DNA methylation; environment; Epigenesis, Genetic; Epigenetics; Generations; Genes; Genetic testing; Genomes; Heredity; Human subjects; Humans; Hypersensitivity - genetics; intergenerational; Molecular modelling; multigenerational; Outdoor air quality; parental; Pregnancy; Public health; Smoking; Studies; Transgenerational; multigenerational; allergy; RHINESSA; asthma; ncRNA; intergenerational; epigenetics; environment; DNAm; DNA methylation; miRNA; Transgenerational; parental

It has become clear that early life (including in utero exposures) is a key window of vulnerability during which environmental exposures can alter developmental trajectories and initiate allergic disease development. However, recent evidence suggests that there might be additional windows of vulnera...