Sulfonylureas exert antidiabetic action on adipocytes by inhibition of PPARγ serine 273 phosphorylation
Sulfonylureas (SUs) are still among the mostly prescribed antidiabetic drugs with an established mode of action: release of insulin from pancreatic β-cells. In addition, effects of SUs on adipocytes by activation of the nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ) have been...
Saved in:
Published in | Molecular metabolism (Germany) Vol. 85; p. 101956 |
---|---|
Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Germany
Elsevier GmbH
01.07.2024
Elsevier |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Sulfonylureas (SUs) are still among the mostly prescribed antidiabetic drugs with an established mode of action: release of insulin from pancreatic β-cells. In addition, effects of SUs on adipocytes by activation of the nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ) have been described, which might explain their insulin-sensitizing potential observed in patients. However, there is a discrepancy between the impact of SUs on antidiabetic action and their rather moderate in vitro effect on PPARγ transcriptional activity. Recent studies have shown that some PPARγ ligands can improve insulin sensitivity by blocking PPARγ Ser-273 phosphorylation without having full agonist activity. It is unknown if SUs elicit their antidiabetic effects on adipocytes by inhibition of PPARγ phosphorylation. Here, we investigated if binding of SUs to PPARγ can interfere with PPARγ Ser-273 phosphorylation and determined their antidiabetic actions in vitro in primary human white adipocytes and in vivo in high-fat diet (HFD) obese mice.
Primary human white preadipocytes were differentiated in the presence of glibenclamide, glimepiride and PPARγ ligands rosiglitazone and SR1664 to compare PPARγ Ser-273 phosphorylation, glucose uptake and adipokine expression. Transcriptional activity at PPARγ was determined by luciferase assays, quantification of PPARγ Ser-273 phosphorylation was determined by Western blotting and CDK5 kinase assays. In silico modelling was performed to gain insight into the binding characteristics of SUs to PPARγ. HFD mice were administered SUs and rosiglitazone for 6 days. PPARγ Ser-273 phosphorylation in white adipose tissue (WAT), body composition, glucose tolerance, adipocyte morphology and expression levels of genes involved in PPARγ activity in WAT and brown adipose tissue (BAT) were evaluated.
SUs inhibit phosphorylation of PPARγ at Ser-273 in primary human white adipocytes and exhibit a positive antidiabetic expression profile, which is characterized by up regulation of insulin-sensitizing and down regulation of insulin resistance-inducing adipokines. We demonstrate that SUs directly bind to PPARγ by in silico modelling and inhibit phosphorylation in kinase assays to a similar extend as rosiglitazone and SR1664. In HFD mice SUs reduce PPARγ phosphorylation in WAT and have comparable effects on gene expression to rosiglitazone. In BAT SUs increase UCP1 expression and reduce lipid droplets sizes.
Our findings indicate that a part of SUs extra-pancreatic effects on adipocytes in vitro and in vivo is probably mediated via their interference with PPARγ phosphorylation rather than via classical agonistic activity at clinical concentrations.
•Sulfonylureas (SUs) inhibit PPARγ serine 273 phosphorylation in primary human adipocytes and in adipose tissue of obese mice.•SUs exhibit a positive antidiabetic expression profile in primary human adipocytes and obese mice.•A new MoA of SUs is proposed which is mediated by inhibition of PPARγ phosphorylation rather than classical PPARγ agonism. |
---|---|
AbstractList | Sulfonylureas (SUs) are still among the mostly prescribed antidiabetic drugs with an established mode of action: release of insulin from pancreatic β-cells. In addition, effects of SUs on adipocytes by activation of the nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ) have been described, which might explain their insulin-sensitizing potential observed in patients. However, there is a discrepancy between the impact of SUs on antidiabetic action and their rather moderate in vitro effect on PPARγ transcriptional activity. Recent studies have shown that some PPARγ ligands can improve insulin sensitivity by blocking PPARγ Ser-273 phosphorylation without having full agonist activity. It is unknown if SUs elicit their antidiabetic effects on adipocytes by inhibition of PPARγ phosphorylation. Here, we investigated if binding of SUs to PPARγ can interfere with PPARγ Ser-273 phosphorylation and determined their antidiabetic actions in vitro in primary human white adipocytes and in vivo in high-fat diet (HFD) obese mice.OBJECTIVESulfonylureas (SUs) are still among the mostly prescribed antidiabetic drugs with an established mode of action: release of insulin from pancreatic β-cells. In addition, effects of SUs on adipocytes by activation of the nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ) have been described, which might explain their insulin-sensitizing potential observed in patients. However, there is a discrepancy between the impact of SUs on antidiabetic action and their rather moderate in vitro effect on PPARγ transcriptional activity. Recent studies have shown that some PPARγ ligands can improve insulin sensitivity by blocking PPARγ Ser-273 phosphorylation without having full agonist activity. It is unknown if SUs elicit their antidiabetic effects on adipocytes by inhibition of PPARγ phosphorylation. Here, we investigated if binding of SUs to PPARγ can interfere with PPARγ Ser-273 phosphorylation and determined their antidiabetic actions in vitro in primary human white adipocytes and in vivo in high-fat diet (HFD) obese mice.Primary human white preadipocytes were differentiated in the presence of glibenclamide, glimepiride and PPARγ ligands rosiglitazone and SR1664 to compare PPARγ Ser-273 phosphorylation, glucose uptake and adipokine expression. Transcriptional activity at PPARγ was determined by luciferase assays, quantification of PPARγ Ser-273 phosphorylation was determined by Western blotting and CDK5 kinase assays. In silico modelling was performed to gain insight into the binding characteristics of SUs to PPARγ. HFD mice were administered SUs and rosiglitazone for 6 days. PPARγ Ser-273 phosphorylation in white adipose tissue (WAT), body composition, glucose tolerance, adipocyte morphology and expression levels of genes involved in PPARγ activity in WAT and brown adipose tissue (BAT) were evaluated.METHODSPrimary human white preadipocytes were differentiated in the presence of glibenclamide, glimepiride and PPARγ ligands rosiglitazone and SR1664 to compare PPARγ Ser-273 phosphorylation, glucose uptake and adipokine expression. Transcriptional activity at PPARγ was determined by luciferase assays, quantification of PPARγ Ser-273 phosphorylation was determined by Western blotting and CDK5 kinase assays. In silico modelling was performed to gain insight into the binding characteristics of SUs to PPARγ. HFD mice were administered SUs and rosiglitazone for 6 days. PPARγ Ser-273 phosphorylation in white adipose tissue (WAT), body composition, glucose tolerance, adipocyte morphology and expression levels of genes involved in PPARγ activity in WAT and brown adipose tissue (BAT) were evaluated.SUs inhibit phosphorylation of PPARγ at Ser-273 in primary human white adipocytes and exhibit a positive antidiabetic expression profile, which is characterized by up regulation of insulin-sensitizing and down regulation of insulin resistance-inducing adipokines. We demonstrate that SUs directly bind to PPARγ by in silico modelling and inhibit phosphorylation in kinase assays to a similar extend as rosiglitazone and SR1664. In HFD mice SUs reduce PPARγ phosphorylation in WAT and have comparable effects on gene expression to rosiglitazone. In BAT SUs increase UCP1 expression and reduce lipid droplets sizes.RESULTSSUs inhibit phosphorylation of PPARγ at Ser-273 in primary human white adipocytes and exhibit a positive antidiabetic expression profile, which is characterized by up regulation of insulin-sensitizing and down regulation of insulin resistance-inducing adipokines. We demonstrate that SUs directly bind to PPARγ by in silico modelling and inhibit phosphorylation in kinase assays to a similar extend as rosiglitazone and SR1664. In HFD mice SUs reduce PPARγ phosphorylation in WAT and have comparable effects on gene expression to rosiglitazone. In BAT SUs increase UCP1 expression and reduce lipid droplets sizes.Our findings indicate that a part of SUs extra-pancreatic effects on adipocytes in vitro and in vivo is probably mediated via their interference with PPARγ phosphorylation rather than via classical agonistic activity at clinical concentrations.CONCLUSIONSOur findings indicate that a part of SUs extra-pancreatic effects on adipocytes in vitro and in vivo is probably mediated via their interference with PPARγ phosphorylation rather than via classical agonistic activity at clinical concentrations. Sulfonylureas (SUs) are still among the mostly prescribed antidiabetic drugs with an established mode of action: release of insulin from pancreatic β-cells. In addition, effects of SUs on adipocytes by activation of the nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ) have been described, which might explain their insulin-sensitizing potential observed in patients. However, there is a discrepancy between the impact of SUs on antidiabetic action and their rather moderate in vitro effect on PPARγ transcriptional activity. Recent studies have shown that some PPARγ ligands can improve insulin sensitivity by blocking PPARγ Ser-273 phosphorylation without having full agonist activity. It is unknown if SUs elicit their antidiabetic effects on adipocytes by inhibition of PPARγ phosphorylation. Here, we investigated if binding of SUs to PPARγ can interfere with PPARγ Ser-273 phosphorylation and determined their antidiabetic actions in vitro in primary human white adipocytes and in vivo in high-fat diet (HFD) obese mice. Primary human white preadipocytes were differentiated in the presence of glibenclamide, glimepiride and PPARγ ligands rosiglitazone and SR1664 to compare PPARγ Ser-273 phosphorylation, glucose uptake and adipokine expression. Transcriptional activity at PPARγ was determined by luciferase assays, quantification of PPARγ Ser-273 phosphorylation was determined by Western blotting and CDK5 kinase assays. In silico modelling was performed to gain insight into the binding characteristics of SUs to PPARγ. HFD mice were administered SUs and rosiglitazone for 6 days. PPARγ Ser-273 phosphorylation in white adipose tissue (WAT), body composition, glucose tolerance, adipocyte morphology and expression levels of genes involved in PPARγ activity in WAT and brown adipose tissue (BAT) were evaluated. SUs inhibit phosphorylation of PPARγ at Ser-273 in primary human white adipocytes and exhibit a positive antidiabetic expression profile, which is characterized by up regulation of insulin-sensitizing and down regulation of insulin resistance-inducing adipokines. We demonstrate that SUs directly bind to PPARγ by in silico modelling and inhibit phosphorylation in kinase assays to a similar extend as rosiglitazone and SR1664. In HFD mice SUs reduce PPARγ phosphorylation in WAT and have comparable effects on gene expression to rosiglitazone. In BAT SUs increase UCP1 expression and reduce lipid droplets sizes. Our findings indicate that a part of SUs extra-pancreatic effects on adipocytes in vitro and in vivo is probably mediated via their interference with PPARγ phosphorylation rather than via classical agonistic activity at clinical concentrations. Sulfonylureas (SUs) are still among the mostly prescribed antidiabetic drugs with an established mode of action: release of insulin from pancreatic β-cells. In addition, effects of SUs on adipocytes by activation of the nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ) have been described, which might explain their insulin-sensitizing potential observed in patients. However, there is a discrepancy between the impact of SUs on antidiabetic action and their rather moderate in vitro effect on PPARγ transcriptional activity. Recent studies have shown that some PPARγ ligands can improve insulin sensitivity by blocking PPARγ Ser-273 phosphorylation without having full agonist activity. It is unknown if SUs elicit their antidiabetic effects on adipocytes by inhibition of PPARγ phosphorylation. Here, we investigated if binding of SUs to PPARγ can interfere with PPARγ Ser-273 phosphorylation and determined their antidiabetic actions in vitro in primary human white adipocytes and in vivo in high-fat diet (HFD) obese mice. Primary human white preadipocytes were differentiated in the presence of glibenclamide, glimepiride and PPARγ ligands rosiglitazone and SR1664 to compare PPARγ Ser-273 phosphorylation, glucose uptake and adipokine expression. Transcriptional activity at PPARγ was determined by luciferase assays, quantification of PPARγ Ser-273 phosphorylation was determined by Western blotting and CDK5 kinase assays. In silico modelling was performed to gain insight into the binding characteristics of SUs to PPARγ. HFD mice were administered SUs and rosiglitazone for 6 days. PPARγ Ser-273 phosphorylation in white adipose tissue (WAT), body composition, glucose tolerance, adipocyte morphology and expression levels of genes involved in PPARγ activity in WAT and brown adipose tissue (BAT) were evaluated. SUs inhibit phosphorylation of PPARγ at Ser-273 in primary human white adipocytes and exhibit a positive antidiabetic expression profile, which is characterized by up regulation of insulin-sensitizing and down regulation of insulin resistance-inducing adipokines. We demonstrate that SUs directly bind to PPARγ by in silico modelling and inhibit phosphorylation in kinase assays to a similar extend as rosiglitazone and SR1664. In HFD mice SUs reduce PPARγ phosphorylation in WAT and have comparable effects on gene expression to rosiglitazone. In BAT SUs increase UCP1 expression and reduce lipid droplets sizes. Our findings indicate that a part of SUs extra-pancreatic effects on adipocytes in vitro and in vivo is probably mediated via their interference with PPARγ phosphorylation rather than via classical agonistic activity at clinical concentrations. •Sulfonylureas (SUs) inhibit PPARγ serine 273 phosphorylation in primary human adipocytes and in adipose tissue of obese mice.•SUs exhibit a positive antidiabetic expression profile in primary human adipocytes and obese mice.•A new MoA of SUs is proposed which is mediated by inhibition of PPARγ phosphorylation rather than classical PPARγ agonism. Objective: Sulfonylureas (SUs) are still among the mostly prescribed antidiabetic drugs with an established mode of action: release of insulin from pancreatic β-cells. In addition, effects of SUs on adipocytes by activation of the nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ) have been described, which might explain their insulin-sensitizing potential observed in patients. However, there is a discrepancy between the impact of SUs on antidiabetic action and their rather moderate in vitro effect on PPARγ transcriptional activity. Recent studies have shown that some PPARγ ligands can improve insulin sensitivity by blocking PPARγ Ser-273 phosphorylation without having full agonist activity. It is unknown if SUs elicit their antidiabetic effects on adipocytes by inhibition of PPARγ phosphorylation. Here, we investigated if binding of SUs to PPARγ can interfere with PPARγ Ser-273 phosphorylation and determined their antidiabetic actions in vitro in primary human white adipocytes and in vivo in high-fat diet (HFD) obese mice. Methods: Primary human white preadipocytes were differentiated in the presence of glibenclamide, glimepiride and PPARγ ligands rosiglitazone and SR1664 to compare PPARγ Ser-273 phosphorylation, glucose uptake and adipokine expression. Transcriptional activity at PPARγ was determined by luciferase assays, quantification of PPARγ Ser-273 phosphorylation was determined by Western blotting and CDK5 kinase assays. In silico modelling was performed to gain insight into the binding characteristics of SUs to PPARγ. HFD mice were administered SUs and rosiglitazone for 6 days. PPARγ Ser-273 phosphorylation in white adipose tissue (WAT), body composition, glucose tolerance, adipocyte morphology and expression levels of genes involved in PPARγ activity in WAT and brown adipose tissue (BAT) were evaluated. Results: SUs inhibit phosphorylation of PPARγ at Ser-273 in primary human white adipocytes and exhibit a positive antidiabetic expression profile, which is characterized by up regulation of insulin-sensitizing and down regulation of insulin resistance-inducing adipokines. We demonstrate that SUs directly bind to PPARγ by in silico modelling and inhibit phosphorylation in kinase assays to a similar extend as rosiglitazone and SR1664. In HFD mice SUs reduce PPARγ phosphorylation in WAT and have comparable effects on gene expression to rosiglitazone. In BAT SUs increase UCP1 expression and reduce lipid droplets sizes. Conclusions: Our findings indicate that a part of SUs extra-pancreatic effects on adipocytes in vitro and in vivo is probably mediated via their interference with PPARγ phosphorylation rather than via classical agonistic activity at clinical concentrations. • Sulfonylureas (SUs) inhibit PPARγ serine 273 phosphorylation in primary human adipocytes and in adipose tissue of obese mice. • SUs exhibit a positive antidiabetic expression profile in primary human adipocytes and obese mice. • A new MoA of SUs is proposed which is mediated by inhibition of PPARγ phosphorylation rather than classical PPARγ agonism. |
ArticleNumber | 101956 |
Author | Hass, Moritz David Sebastian Vogel, Matthias Voltz, Alexander Pfeifer, Alexander Walther, Julia Biswas, Arijit Haas, Bodo Hass, Daniela |
Author_xml | – sequence: 1 givenname: Bodo orcidid: 0000-0002-1213-3527 surname: Haas fullname: Haas, Bodo email: bodo.haas@bfarm.de organization: Federal Institute for Drugs and Medical Devices (BfArM), Bonn, Germany – sequence: 2 givenname: Moritz David Sebastian surname: Hass fullname: Hass, Moritz David Sebastian organization: Federal Institute for Drugs and Medical Devices (BfArM), Bonn, Germany – sequence: 3 givenname: Alexander surname: Voltz fullname: Voltz, Alexander organization: Institute of Pharmacology and Toxicology, University Hospital, University of Bonn, Bonn, Germany – sequence: 4 givenname: Matthias surname: Vogel fullname: Vogel, Matthias organization: Federal Institute for Drugs and Medical Devices (BfArM), Bonn, Germany – sequence: 5 givenname: Julia surname: Walther fullname: Walther, Julia organization: Federal Institute for Drugs and Medical Devices (BfArM), Bonn, Germany – sequence: 6 givenname: Arijit surname: Biswas fullname: Biswas, Arijit organization: Institute of Experimental Hematology and Transfusion Medicine, University Hospital, University of Bonn, Bonn, Germany – sequence: 7 givenname: Daniela surname: Hass fullname: Hass, Daniela organization: Institute of Pharmacology and Toxicology, University Hospital, University of Bonn, Bonn, Germany – sequence: 8 givenname: Alexander surname: Pfeifer fullname: Pfeifer, Alexander organization: Institute of Pharmacology and Toxicology, University Hospital, University of Bonn, Bonn, Germany |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38735390$$D View this record in MEDLINE/PubMed |
BookMark | eNp9Udtu1DAQjVARLaV_gFAeednFdycvoKriUqkSFZdnyxlPul5l7cXOVuS7-A--CYeUqn1hZMvWzJlz7DnPq6MQA1bVS0rWlFD1ZrvexWGH45oRJuZUK9WT6oQxylaN1s3Rg_txdZbzlpRolFKSPquOeaO55C05qTZfD0MfwzQcEtpc409MY23D6J23HY4eagujj6Euyzq_jzCNmOtuqn3Y-M4vtb6-vj7_8vtXnTH5gDXTvN5vYi47TYOdQS-qp70dMp7dnafV9w_vv118Wl19_nh5cX61At4KteqRdAASZOuEbkVvKWoiJDROEtaqTkKrkSIBSjtoRauFQOqkw4Yha9Dy0-py4XXRbs0--Z1Nk4nWm7-JmG6MTeVfAxrkoHqw2nWaC6pcJ1kvtWJUMaA9tIXr3cK1P3Q7dIBhTHZ4RPq4EvzG3MRbQ0swRVlheH3HkOKPA-bR7HwGHAYbMB6y4UQKwblQs5hYoJBizgn7ex1KzGy62ZrFdDObbhbTS9urh2-8b_pncQG8XQBYpn7rMZkMHgOg8wlhLGPx_1f4A8HDxAA |
Cites_doi | 10.1101/gad.249367.114 10.1074/jbc.270.22.12953 10.1016/j.diabres.2021.109119 10.1055/s-2007-979839 10.1016/j.biopha.2007.12.007 10.1016/S0149-2918(04)90006-9 10.1016/j.bmcl.2004.10.068 10.1016/j.cmet.2020.08.016 10.1016/j.metop.2022.100221 10.1016/0092-8674(95)90193-0 10.3389/fphar.2021.807548 10.1016/j.cmet.2012.01.019 10.1016/j.cell.2012.06.027 10.1074/jbc.M114.566794 10.1016/j.bbrc.2004.12.190 10.1016/j.jbc.2021.101030 10.1111/j.1463-1326.2011.01409.x 10.1111/dom.13843 10.1371/journal.pone.0154310 10.1055/s-2007-979838 10.4093/dmj.2011.35.4.340 10.2337/dc23-S009 10.1038/nature09291 10.1101/gad.8.10.1224 10.1016/j.metabol.2021.154892 10.1096/fj.12-221580 10.1124/mol.106.024596 10.2337/dbi23-0005 10.3390/cells9020343 10.1016/j.molmet.2021.101363 10.1111/j.1463-1326.2008.00870.x 10.1172/JCI98709 10.3389/fendo.2020.561256 10.1111/j.1365-2125.1990.tb03688.x 10.1146/annurev.biochem.77.061307.091829 10.1038/nature13887 10.1038/ncomms2742 10.1016/j.isci.2020.101446 10.1016/j.bmcl.2006.08.003 10.1073/pnas.95.8.4333 10.1038/nature10383 10.1038/s41586-022-05041-0 10.2165/00003495-199855040-00007 10.1371/journal.pmed.0050206 10.1016/j.jbc.2023.103059 10.1111/bph.14553 10.1007/s13300-019-0651-1 10.1074/jbc.M412113200 10.1126/scisignal.2000511 |
ContentType | Journal Article |
Copyright | 2024 The Author(s) Copyright © 2024 The Author(s). Published by Elsevier GmbH.. All rights reserved. 2024 The Author(s) 2024 |
Copyright_xml | – notice: 2024 The Author(s) – notice: Copyright © 2024 The Author(s). Published by Elsevier GmbH.. All rights reserved. – notice: 2024 The Author(s) 2024 |
DBID | 6I. AAFTH NPM AAYXX CITATION 7X8 5PM DOA |
DOI | 10.1016/j.molmet.2024.101956 |
DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access PubMed CrossRef MEDLINE - Academic PubMed Central (Full Participant titles) Directory of Open Access Journals |
DatabaseTitle | PubMed CrossRef MEDLINE - Academic |
DatabaseTitleList | MEDLINE - Academic PubMed |
Database_xml | – sequence: 1 dbid: DOA name: Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Biology |
EISSN | 2212-8778 |
ExternalDocumentID | oai_doaj_org_article_e3c6fca7db73416db52f5762162c1fc9 10_1016_j_molmet_2024_101956 38735390 S2212877824000875 |
Genre | Journal Article |
GroupedDBID | -IN .1- .FO 0R~ 0SF 1P~ 457 4G. 53G 5VS 6I. 7-5 AACTN AAEDT AAEDW AAFTH AAIKJ AALRI AAXUO ABMAC ACGFS ADBBV ADEZE AEVXI AEXQZ AFCTW AFRHN AFTJW AGHFR AITUG AJUYK AKRWK ALMA_UNASSIGNED_HOLDINGS AMRAJ AOIJS BAWUL BCNDV DIK EBS EJD FDB GROUPED_DOAJ HYE HZ~ IPNFZ IXB KQ8 M41 M48 M~E NCXOZ O-L O9- OB0 OK1 ON- RIG ROL RPM SSZ Z5R ADVLN AFJKZ NPM AAYXX CITATION 7X8 5PM |
ID | FETCH-LOGICAL-c3946-fe0bcc5c59d4794fa1e7045c8d50296b5c97e1e0c11bc949744e1d5de82e28ea3 |
IEDL.DBID | RPM |
ISSN | 2212-8778 |
IngestDate | Sun Sep 29 07:15:10 EDT 2024 Tue Sep 17 21:28:24 EDT 2024 Fri Jul 12 19:43:28 EDT 2024 Thu Sep 26 21:41:51 EDT 2024 Wed Oct 16 00:11:48 EDT 2024 Sat Jun 29 15:30:37 EDT 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Keywords | Brown adipose tissue White adipose tissue PPARγ Sulfonylureas |
Language | English |
License | This is an open access article under the CC BY license. Copyright © 2024 The Author(s). Published by Elsevier GmbH.. All rights reserved. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c3946-fe0bcc5c59d4794fa1e7045c8d50296b5c97e1e0c11bc949744e1d5de82e28ea3 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Bodo Haas and Moritz David Sebastian Hass contributed equally to this work. |
ORCID | 0000-0002-1213-3527 |
OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11112612/ |
PMID | 38735390 |
PQID | 3054433469 |
PQPubID | 23479 |
ParticipantIDs | doaj_primary_oai_doaj_org_article_e3c6fca7db73416db52f5762162c1fc9 pubmedcentral_primary_oai_pubmedcentral_nih_gov_11112612 proquest_miscellaneous_3054433469 crossref_primary_10_1016_j_molmet_2024_101956 pubmed_primary_38735390 elsevier_sciencedirect_doi_10_1016_j_molmet_2024_101956 |
PublicationCentury | 2000 |
PublicationDate | 2024-07-01 |
PublicationDateYYYYMMDD | 2024-07-01 |
PublicationDate_xml | – month: 07 year: 2024 text: 2024-07-01 day: 01 |
PublicationDecade | 2020 |
PublicationPlace | Germany |
PublicationPlace_xml | – name: Germany |
PublicationTitle | Molecular metabolism (Germany) |
PublicationTitleAlternate | Mol Metab |
PublicationYear | 2024 |
Publisher | Elsevier GmbH Elsevier |
Publisher_xml | – name: Elsevier GmbH – name: Elsevier |
References | Koshiba, Nomura, Nakaya, Ito (bib6) 2006; 53 Choi, Choi, Kim, Jedrychowski, Yang, Jang (bib22) 2014; 28 Zhou, Zhang, Zou, Shen, Xie, Xu (bib48) 2019; 176 Inukai, Watanabe, Nakashima, Takata, Isoyama, Sawa (bib9) 2005; 328 Kim, Wright, Wright, Spiegelman (bib32) 1998; 95 Mastrototaro, Roden (bib18) 2021; 125 Mitschke, Hoffmann, Gnad, Scholz, Kruithoff, Mayer (bib29) 2013; 27 Remedi, Nichols (bib36) 2008; 5 Tontonoz, Hu, Graves, Budavari, Spiegelman (bib33) 1994; 8 Yu, Hu, Sheng, Gao, Guo, Zhang (bib41) 2023; 299 Hopkins, O'Neil S, Laufersweiler, Wang, Pokross, Mekel (bib44) 2006; 16 Dias, Batista, Tittanegro, de Oliveira, Le Maire, Torres (bib23) 2020; 11 Sun, Saeedi, Karuranga, Pinkepank, Ogurtsova, Duncan (bib1) 2022; 183 Arrault, Rocchi, Picard, Maurois, Pirotte, Vamecq (bib15) 2009; 63 Langtry, Balfour (bib46) 1998; 55 Chen, Siegel, Kipschull, Haas, Frohlich, Meister (bib31) 2013; 4 Muller, Geisen (bib11) 1996; 28 Tontonoz, Spiegelman (bib14) 2008; 77 Lehmann, Moore, Smith-Oliver, Wilkison, Willson, Kliewer (bib17) 1995; 270 Gilani, Stoll, Homan, Lo (bib34) 2024; 73 Coppack, Lant, McIntosh, Rodgers (bib47) 1990; 29 Choi, Banks, Estall, Kajimura, Bostrom, Laznik (bib19) 2010; 466 Coelho, de Lima, Royer, Silva, Oliveira, Christ (bib39) 2016; 11 Kalra, Das, Baruah, Unnikrishnan, Dasgupta, Shah (bib51) 2019; 10 ElSayed, Aleppo, Aroda, Bannuru, Brown, Bruemmer (bib2) 2022; 46 Fukuen, Iwaki, Yasui, Makishima, Matsuda, Shimomura (bib8) 2005; 280 Qiu, Yang, Wei, Liu, Feng, Zeng (bib37) 2020; 23 Ohno, Shinoda, Spiegelman, Kajimura (bib43) 2012; 15 Huan, Pan, Peng, Jia, Sun, Bai (bib40) 2019; 21 Acton, Black, Jones, Moller, Colwell, Doebber (bib26) 2005; 15 Kabadi, Kabadi (bib5) 2004; 26 Haas, Mayer, Jennissen, Scholz, Berriel Diaz, Bloch (bib30) 2009; 2 Hall, Ramachandran, Roh, DiSpirito, Belchior, Zushin (bib24) 2020; 32 Dahlén, Dashi, Maslov, Attwood, Jonsson, Trukhan (bib3) 2022; 12 Scarsi, Podvinec, Roth, Hug, Kersten, Albrecht (bib12) 2007; 71 Lee, Ku, Kim, Ahn, Chung, Park (bib13) 2011; 35 Khim, Choi, Jang, Lee, Lee, Hyun (bib25) 2020; 9 Niedowicz, Ozcan, Nelson (bib35) 2018; 2018 Kramer, Muller, Geisen (bib4) 1996; 28 Frkic, Richter, Bruning (bib45) 2021; 297 Wu, Eeda, Undi, Mann, Stout, Lim (bib42) 2021; 54 Kraakman, Liu, Postigo-Fernandez, Ji, Kon, Larrea (bib50) 2018; 128 Banks, McAllister, Camporez, Zushin, Jurczak, Laznik-Bogoslavski (bib21) 2015; 517 Forman, Tontonoz, Chen, Brun, Spiegelman, Evans (bib16) 1995; 83 Niemann, Haufs-Brusberg, Puetz, Feickert, Jaeckstein, Hoffmann (bib28) 2022; 609 Mori, Hirabara, Hirata, Okamoto, Machado (bib7) 2008; 10 Qiang, Wang, Kon, Zhao, Lee, Zhang (bib49) 2012; 150 Terra, Garcia-Arevalo, Avelino, Degaki, Malospirito, de Carvalho (bib38) 2023; 17 Mayer, Haas, Celner, Enzmann, Pfeifer (bib10) 2011; 13 Choi, Banks, Kamenecka, Busby, Chalmers, Kumar (bib20) 2011; 477 Choi, Kim, Koh, Lee, Lim, Yang (bib27) 2014; 289 Dias (10.1016/j.molmet.2024.101956_bib23) 2020; 11 Lehmann (10.1016/j.molmet.2024.101956_bib17) 1995; 270 Niemann (10.1016/j.molmet.2024.101956_bib28) 2022; 609 Kramer (10.1016/j.molmet.2024.101956_bib4) 1996; 28 Mori (10.1016/j.molmet.2024.101956_bib7) 2008; 10 Wu (10.1016/j.molmet.2024.101956_bib42) 2021; 54 Huan (10.1016/j.molmet.2024.101956_bib40) 2019; 21 Mitschke (10.1016/j.molmet.2024.101956_bib29) 2013; 27 Dahlén (10.1016/j.molmet.2024.101956_bib3) 2022; 12 Qiu (10.1016/j.molmet.2024.101956_bib37) 2020; 23 Arrault (10.1016/j.molmet.2024.101956_bib15) 2009; 63 Kabadi (10.1016/j.molmet.2024.101956_bib5) 2004; 26 Lee (10.1016/j.molmet.2024.101956_bib13) 2011; 35 Choi (10.1016/j.molmet.2024.101956_bib20) 2011; 477 Hopkins (10.1016/j.molmet.2024.101956_bib44) 2006; 16 Banks (10.1016/j.molmet.2024.101956_bib21) 2015; 517 Muller (10.1016/j.molmet.2024.101956_bib11) 1996; 28 Scarsi (10.1016/j.molmet.2024.101956_bib12) 2007; 71 ElSayed (10.1016/j.molmet.2024.101956_bib2) 2022; 46 Chen (10.1016/j.molmet.2024.101956_bib31) 2013; 4 Mayer (10.1016/j.molmet.2024.101956_bib10) 2011; 13 Kalra (10.1016/j.molmet.2024.101956_bib51) 2019; 10 Hall (10.1016/j.molmet.2024.101956_bib24) 2020; 32 Mastrototaro (10.1016/j.molmet.2024.101956_bib18) 2021; 125 Tontonoz (10.1016/j.molmet.2024.101956_bib14) 2008; 77 Tontonoz (10.1016/j.molmet.2024.101956_bib33) 1994; 8 Remedi (10.1016/j.molmet.2024.101956_bib36) 2008; 5 Choi (10.1016/j.molmet.2024.101956_bib27) 2014; 289 Terra (10.1016/j.molmet.2024.101956_bib38) 2023; 17 Inukai (10.1016/j.molmet.2024.101956_bib9) 2005; 328 Forman (10.1016/j.molmet.2024.101956_bib16) 1995; 83 Coppack (10.1016/j.molmet.2024.101956_bib47) 1990; 29 Qiang (10.1016/j.molmet.2024.101956_bib49) 2012; 150 Haas (10.1016/j.molmet.2024.101956_bib30) 2009; 2 Kraakman (10.1016/j.molmet.2024.101956_bib50) 2018; 128 Frkic (10.1016/j.molmet.2024.101956_bib45) 2021; 297 Khim (10.1016/j.molmet.2024.101956_bib25) 2020; 9 Acton (10.1016/j.molmet.2024.101956_bib26) 2005; 15 Langtry (10.1016/j.molmet.2024.101956_bib46) 1998; 55 Yu (10.1016/j.molmet.2024.101956_bib41) 2023; 299 Coelho (10.1016/j.molmet.2024.101956_bib39) 2016; 11 Sun (10.1016/j.molmet.2024.101956_bib1) 2022; 183 Choi (10.1016/j.molmet.2024.101956_bib22) 2014; 28 Ohno (10.1016/j.molmet.2024.101956_bib43) 2012; 15 Zhou (10.1016/j.molmet.2024.101956_bib48) 2019; 176 Choi (10.1016/j.molmet.2024.101956_bib19) 2010; 466 Kim (10.1016/j.molmet.2024.101956_bib32) 1998; 95 Niedowicz (10.1016/j.molmet.2024.101956_bib35) 2018; 2018 Koshiba (10.1016/j.molmet.2024.101956_bib6) 2006; 53 Gilani (10.1016/j.molmet.2024.101956_bib34) 2024; 73 Fukuen (10.1016/j.molmet.2024.101956_bib8) 2005; 280 |
References_xml | – volume: 466 start-page: 451 year: 2010 end-page: 456 ident: bib19 article-title: Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5 publication-title: Nature contributor: fullname: Laznik – volume: 28 start-page: 469 year: 1996 end-page: 487 ident: bib11 article-title: Characterization of the molecular mode of action of the sulfonylurea, glimepiride, at adipocytes publication-title: Horm Metab Res contributor: fullname: Geisen – volume: 270 start-page: 12953 year: 1995 end-page: 12956 ident: bib17 article-title: An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma) publication-title: J Biol Chem contributor: fullname: Kliewer – volume: 289 start-page: 26618 year: 2014 end-page: 26629 ident: bib27 article-title: A novel non-agonist peroxisome proliferator-activated receptor gamma (PPARgamma) ligand UHC1 blocks PPARgamma phosphorylation by cyclin-dependent kinase 5 (CDK5) and improves insulin sensitivity publication-title: J Biol Chem contributor: fullname: Yang – volume: 17 year: 2023 ident: bib38 article-title: AM-879, a PPARy non-agonist and Ser273 phosphorylation blocker, promotes insulin sensitivity without adverse effects in mice publication-title: Metabol Open contributor: fullname: de Carvalho – volume: 4 start-page: 1769 year: 2013 ident: bib31 article-title: miR-155 regulates differentiation of brown and beige adipocytes via a bistable circuit publication-title: Nat Commun contributor: fullname: Meister – volume: 12 year: 2022 ident: bib3 article-title: Trends in antidiabetic drug discovery: FDA approved drugs, new drugs in clinical trials and global sales publication-title: Front Pharmacol contributor: fullname: Trukhan – volume: 73 start-page: 169 year: 2024 end-page: 177 ident: bib34 article-title: Adipose signals regulating distal organ health and disease publication-title: Diabetes contributor: fullname: Lo – volume: 299 year: 2023 ident: bib41 article-title: Selective PPARgamma modulator diosmin improves insulin sensitivity and promotes browning of white fat publication-title: J Biol Chem contributor: fullname: Zhang – volume: 16 start-page: 5659 year: 2006 end-page: 5663 ident: bib44 article-title: Design and synthesis of novel N-sulfonyl-2-indole carboxamides as potent PPAR-gamma binding agents with potential application to the treatment of osteoporosis publication-title: Bioorg Med Chem Lett contributor: fullname: Mekel – volume: 128 start-page: 2600 year: 2018 end-page: 2612 ident: bib50 article-title: PPARgamma deacetylation dissociates thiazolidinedione's metabolic benefits from its adverse effects publication-title: J Clin Invest contributor: fullname: Larrea – volume: 609 start-page: 361 year: 2022 end-page: 368 ident: bib28 article-title: Apoptotic brown adipocytes enhance energy expenditure via extracellular inosine publication-title: Nature contributor: fullname: Hoffmann – volume: 13 start-page: 791 year: 2011 end-page: 799 ident: bib10 article-title: Glitazone-like action of glimepiride and glibenclamide in primary human adipocytes publication-title: Diabetes Obes Metabol contributor: fullname: Pfeifer – volume: 10 start-page: 1577 year: 2019 end-page: 1593 ident: bib51 article-title: Glucocrinology of modern sulfonylureas: clinical evidence and practice-based opinion from an international expert group publication-title: Diabetes Ther contributor: fullname: Shah – volume: 53 start-page: 87 year: 2006 end-page: 94 ident: bib6 article-title: Efficacy of glimepiride on insulin resistance, adipocytokines, and atherosclerosis publication-title: J Med Invest contributor: fullname: Ito – volume: 183 year: 2022 ident: bib1 article-title: IDF Diabetes Atlas: global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045 publication-title: Diabetes Res Clin Pract contributor: fullname: Duncan – volume: 46 start-page: S140 year: 2022 end-page: S157 ident: bib2 article-title: 9. Pharmacologic approaches to glycemic treatment: standards of care in diabetes—2023 publication-title: Diabetes Care contributor: fullname: Bruemmer – volume: 54 year: 2021 ident: bib42 article-title: A novel peroxisome proliferator-activated receptor gamma ligand improves insulin sensitivity and promotes browning of white adipose tissue in obese mice publication-title: Mol Metabol contributor: fullname: Lim – volume: 29 start-page: 673 year: 1990 end-page: 684 ident: bib47 article-title: Pharmacokinetic and pharmacodynamic studies of glibenclamide in non-insulin dependent diabetes mellitus publication-title: Br J Clin Pharmacol contributor: fullname: Rodgers – volume: 83 start-page: 803 year: 1995 end-page: 812 ident: bib16 article-title: 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma publication-title: Cell contributor: fullname: Evans – volume: 26 start-page: 63 year: 2004 end-page: 69 ident: bib5 article-title: Effects of glimepiride on insulin secretion and sensitivity in patients with recently diagnosed type 2 diabetes mellitus publication-title: Clin Therapeut contributor: fullname: Kabadi – volume: 35 start-page: 340 year: 2011 end-page: 347 ident: bib13 article-title: Effects of sulfonylureas on peroxisome proliferator-activated receptor gamma activity and on glucose uptake by thiazolidinediones publication-title: Diabetes Metab J contributor: fullname: Park – volume: 297 year: 2021 ident: bib45 article-title: The therapeutic potential of inhibiting PPARgamma phosphorylation to treat type 2 diabetes publication-title: J Biol Chem contributor: fullname: Bruning – volume: 63 start-page: 56 year: 2009 end-page: 62 ident: bib15 article-title: A short series of antidiabetic sulfonylureas exhibit multiple ligand PPARgamma-binding patterns publication-title: Biomed Pharmacother contributor: fullname: Vamecq – volume: 11 year: 2016 ident: bib39 article-title: GQ-16, a TZD-derived partial PPARgamma agonist, induces the expression of thermogenesis-related genes in Brown fat and visceral white fat and decreases visceral adiposity in obese and hyperglycemic mice publication-title: PLoS One contributor: fullname: Christ – volume: 477 start-page: 477 year: 2011 end-page: 481 ident: bib20 article-title: Antidiabetic actions of a non-agonist PPARgamma ligand blocking Cdk5-mediated phosphorylation publication-title: Nature contributor: fullname: Kumar – volume: 11 year: 2020 ident: bib23 article-title: PPARgamma S273 phosphorylation modifies the dynamics of coregulator proteins recruitment publication-title: Front Endocrinol contributor: fullname: Torres – volume: 21 start-page: 2553 year: 2019 end-page: 2563 ident: bib40 article-title: A novel specific peroxisome proliferator-activated receptor gamma (PPARgamma) modulator YR4-42 ameliorates hyperglycaemia and dyslipidaemia and hepatic steatosis in diet-induced obese mice publication-title: Diabetes Obes Metabol contributor: fullname: Bai – volume: 71 start-page: 398 year: 2007 end-page: 406 ident: bib12 article-title: Sulfonylureas and glinides exhibit peroxisome proliferator-activated receptor gamma activity: a combined virtual screening and biological assay approach publication-title: Mol Pharmacol contributor: fullname: Albrecht – volume: 10 start-page: 596 year: 2008 end-page: 600 ident: bib7 article-title: Glimepiride as insulin sensitizer: increased liver and muscle responses to insulin publication-title: Diabetes Obes Metabol contributor: fullname: Machado – volume: 2 start-page: ra78 year: 2009 ident: bib30 article-title: Protein kinase G controls brown fat cell differentiation and mitochondrial biogenesis publication-title: Sci Signal contributor: fullname: Bloch – volume: 23 year: 2020 ident: bib37 article-title: Glyburide regulates UCP1 expression in adipocytes independent of K(ATP) channel blockade publication-title: iScience contributor: fullname: Zeng – volume: 176 start-page: 478 year: 2019 end-page: 490 ident: bib48 article-title: Hypoglycaemic effects of glimepiride in sulfonylurea receptor 1 deficient rat publication-title: Br J Pharmacol contributor: fullname: Xu – volume: 328 start-page: 484 year: 2005 end-page: 490 ident: bib9 article-title: Glimepiride enhances intrinsic peroxisome proliferator-activated receptor-gamma activity in 3T3-L1 adipocytes publication-title: Biochem Biophys Res Commun contributor: fullname: Sawa – volume: 27 start-page: 1621 year: 2013 end-page: 1630 ident: bib29 article-title: Increased cGMP promotes healthy expansion and browning of white adipose tissue publication-title: Faseb J contributor: fullname: Mayer – volume: 8 start-page: 1224 year: 1994 end-page: 1234 ident: bib33 article-title: mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer publication-title: Genes Dev contributor: fullname: Spiegelman – volume: 95 start-page: 4333 year: 1998 end-page: 4337 ident: bib32 article-title: ADD1/SREBP1 activates PPARgamma through the production of endogenous ligand publication-title: Proc Natl Acad Sci U S A contributor: fullname: Spiegelman – volume: 5 year: 2008 ident: bib36 article-title: Chronic antidiabetic sulfonylureas in vivo: reversible effects on mouse pancreatic beta-cells publication-title: PLoS Med contributor: fullname: Nichols – volume: 28 start-page: 464 year: 1996 end-page: 468 ident: bib4 article-title: Characterization of the molecular mode of action of the sulfonylurea, glimepiride, at beta-cells publication-title: Horm Metab Res contributor: fullname: Geisen – volume: 9 year: 2020 ident: bib25 article-title: PPM1A controls diabetic gene programming through directly dephosphorylating PPARgamma at Ser273 publication-title: Cells contributor: fullname: Hyun – volume: 55 start-page: 563 year: 1998 end-page: 584 ident: bib46 article-title: Glimepiride. A review of its use in the management of type 2 diabetes mellitus publication-title: Drugs contributor: fullname: Balfour – volume: 517 start-page: 391 year: 2015 end-page: 395 ident: bib21 article-title: An ERK/Cdk5 axis controls the diabetogenic actions of PPARgamma publication-title: Nature contributor: fullname: Laznik-Bogoslavski – volume: 125 year: 2021 ident: bib18 article-title: Insulin resistance and insulin sensitizing agents publication-title: Metabolism contributor: fullname: Roden – volume: 77 start-page: 289 year: 2008 end-page: 312 ident: bib14 article-title: Fat and beyond: the diverse biology of PPARgamma publication-title: Annu Rev Biochem contributor: fullname: Spiegelman – volume: 32 start-page: 665 year: 2020 end-page: 675 e666 ident: bib24 article-title: Obesity-linked PPARgamma S273 phosphorylation promotes insulin resistance through growth differentiation factor 3 publication-title: Cell Metabol contributor: fullname: Zushin – volume: 28 start-page: 2361 year: 2014 end-page: 2369 ident: bib22 article-title: Thrap3 docks on phosphoserine 273 of PPARgamma and controls diabetic gene programming publication-title: Genes Dev contributor: fullname: Jang – volume: 280 start-page: 23653 year: 2005 end-page: 23659 ident: bib8 article-title: Sulfonylurea agents exhibit peroxisome proliferator-activated receptor gamma agonistic activity publication-title: J Biol Chem contributor: fullname: Shimomura – volume: 15 start-page: 357 year: 2005 end-page: 362 ident: bib26 article-title: Benzoyl 2-methyl indoles as selective PPARgamma modulators publication-title: Bioorg Med Chem Lett contributor: fullname: Doebber – volume: 2018 year: 2018 ident: bib35 article-title: Glimepiride administered in chow reversibly impairs glucose tolerance in mice publication-title: J Diabetes Res contributor: fullname: Nelson – volume: 15 start-page: 395 year: 2012 end-page: 404 ident: bib43 article-title: PPARgamma agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein publication-title: Cell Metabol contributor: fullname: Kajimura – volume: 150 start-page: 620 year: 2012 end-page: 632 ident: bib49 article-title: Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Ppargamma publication-title: Cell contributor: fullname: Zhang – volume: 28 start-page: 2361 issue: 21 year: 2014 ident: 10.1016/j.molmet.2024.101956_bib22 article-title: Thrap3 docks on phosphoserine 273 of PPARgamma and controls diabetic gene programming publication-title: Genes Dev doi: 10.1101/gad.249367.114 contributor: fullname: Choi – volume: 270 start-page: 12953 issue: 22 year: 1995 ident: 10.1016/j.molmet.2024.101956_bib17 article-title: An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma) publication-title: J Biol Chem doi: 10.1074/jbc.270.22.12953 contributor: fullname: Lehmann – volume: 183 year: 2022 ident: 10.1016/j.molmet.2024.101956_bib1 article-title: IDF Diabetes Atlas: global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045 publication-title: Diabetes Res Clin Pract doi: 10.1016/j.diabres.2021.109119 contributor: fullname: Sun – volume: 53 start-page: 87 issue: 1–2 year: 2006 ident: 10.1016/j.molmet.2024.101956_bib6 article-title: Efficacy of glimepiride on insulin resistance, adipocytokines, and atherosclerosis publication-title: J Med Invest contributor: fullname: Koshiba – volume: 28 start-page: 469 issue: 9 year: 1996 ident: 10.1016/j.molmet.2024.101956_bib11 article-title: Characterization of the molecular mode of action of the sulfonylurea, glimepiride, at adipocytes publication-title: Horm Metab Res doi: 10.1055/s-2007-979839 contributor: fullname: Muller – volume: 63 start-page: 56 issue: 1 year: 2009 ident: 10.1016/j.molmet.2024.101956_bib15 article-title: A short series of antidiabetic sulfonylureas exhibit multiple ligand PPARgamma-binding patterns publication-title: Biomed Pharmacother doi: 10.1016/j.biopha.2007.12.007 contributor: fullname: Arrault – volume: 26 start-page: 63 issue: 1 year: 2004 ident: 10.1016/j.molmet.2024.101956_bib5 article-title: Effects of glimepiride on insulin secretion and sensitivity in patients with recently diagnosed type 2 diabetes mellitus publication-title: Clin Therapeut doi: 10.1016/S0149-2918(04)90006-9 contributor: fullname: Kabadi – volume: 2018 year: 2018 ident: 10.1016/j.molmet.2024.101956_bib35 article-title: Glimepiride administered in chow reversibly impairs glucose tolerance in mice publication-title: J Diabetes Res contributor: fullname: Niedowicz – volume: 15 start-page: 357 issue: 2 year: 2005 ident: 10.1016/j.molmet.2024.101956_bib26 article-title: Benzoyl 2-methyl indoles as selective PPARgamma modulators publication-title: Bioorg Med Chem Lett doi: 10.1016/j.bmcl.2004.10.068 contributor: fullname: Acton – volume: 32 start-page: 665 issue: 4 year: 2020 ident: 10.1016/j.molmet.2024.101956_bib24 article-title: Obesity-linked PPARgamma S273 phosphorylation promotes insulin resistance through growth differentiation factor 3 publication-title: Cell Metabol doi: 10.1016/j.cmet.2020.08.016 contributor: fullname: Hall – volume: 17 year: 2023 ident: 10.1016/j.molmet.2024.101956_bib38 article-title: AM-879, a PPARy non-agonist and Ser273 phosphorylation blocker, promotes insulin sensitivity without adverse effects in mice publication-title: Metabol Open doi: 10.1016/j.metop.2022.100221 contributor: fullname: Terra – volume: 83 start-page: 803 issue: 5 year: 1995 ident: 10.1016/j.molmet.2024.101956_bib16 article-title: 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma publication-title: Cell doi: 10.1016/0092-8674(95)90193-0 contributor: fullname: Forman – volume: 12 year: 2022 ident: 10.1016/j.molmet.2024.101956_bib3 article-title: Trends in antidiabetic drug discovery: FDA approved drugs, new drugs in clinical trials and global sales publication-title: Front Pharmacol doi: 10.3389/fphar.2021.807548 contributor: fullname: Dahlén – volume: 15 start-page: 395 issue: 3 year: 2012 ident: 10.1016/j.molmet.2024.101956_bib43 article-title: PPARgamma agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein publication-title: Cell Metabol doi: 10.1016/j.cmet.2012.01.019 contributor: fullname: Ohno – volume: 150 start-page: 620 issue: 3 year: 2012 ident: 10.1016/j.molmet.2024.101956_bib49 article-title: Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Ppargamma publication-title: Cell doi: 10.1016/j.cell.2012.06.027 contributor: fullname: Qiang – volume: 289 start-page: 26618 issue: 38 year: 2014 ident: 10.1016/j.molmet.2024.101956_bib27 article-title: A novel non-agonist peroxisome proliferator-activated receptor gamma (PPARgamma) ligand UHC1 blocks PPARgamma phosphorylation by cyclin-dependent kinase 5 (CDK5) and improves insulin sensitivity publication-title: J Biol Chem doi: 10.1074/jbc.M114.566794 contributor: fullname: Choi – volume: 328 start-page: 484 issue: 2 year: 2005 ident: 10.1016/j.molmet.2024.101956_bib9 article-title: Glimepiride enhances intrinsic peroxisome proliferator-activated receptor-gamma activity in 3T3-L1 adipocytes publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2004.12.190 contributor: fullname: Inukai – volume: 297 issue: 3 year: 2021 ident: 10.1016/j.molmet.2024.101956_bib45 article-title: The therapeutic potential of inhibiting PPARgamma phosphorylation to treat type 2 diabetes publication-title: J Biol Chem doi: 10.1016/j.jbc.2021.101030 contributor: fullname: Frkic – volume: 13 start-page: 791 issue: 9 year: 2011 ident: 10.1016/j.molmet.2024.101956_bib10 article-title: Glitazone-like action of glimepiride and glibenclamide in primary human adipocytes publication-title: Diabetes Obes Metabol doi: 10.1111/j.1463-1326.2011.01409.x contributor: fullname: Mayer – volume: 21 start-page: 2553 issue: 11 year: 2019 ident: 10.1016/j.molmet.2024.101956_bib40 article-title: A novel specific peroxisome proliferator-activated receptor gamma (PPARgamma) modulator YR4-42 ameliorates hyperglycaemia and dyslipidaemia and hepatic steatosis in diet-induced obese mice publication-title: Diabetes Obes Metabol doi: 10.1111/dom.13843 contributor: fullname: Huan – volume: 11 issue: 5 year: 2016 ident: 10.1016/j.molmet.2024.101956_bib39 article-title: GQ-16, a TZD-derived partial PPARgamma agonist, induces the expression of thermogenesis-related genes in Brown fat and visceral white fat and decreases visceral adiposity in obese and hyperglycemic mice publication-title: PLoS One doi: 10.1371/journal.pone.0154310 contributor: fullname: Coelho – volume: 28 start-page: 464 issue: 9 year: 1996 ident: 10.1016/j.molmet.2024.101956_bib4 article-title: Characterization of the molecular mode of action of the sulfonylurea, glimepiride, at beta-cells publication-title: Horm Metab Res doi: 10.1055/s-2007-979838 contributor: fullname: Kramer – volume: 35 start-page: 340 issue: 4 year: 2011 ident: 10.1016/j.molmet.2024.101956_bib13 article-title: Effects of sulfonylureas on peroxisome proliferator-activated receptor gamma activity and on glucose uptake by thiazolidinediones publication-title: Diabetes Metab J doi: 10.4093/dmj.2011.35.4.340 contributor: fullname: Lee – volume: 46 start-page: S140 issue: Supplement_1 year: 2022 ident: 10.1016/j.molmet.2024.101956_bib2 article-title: 9. Pharmacologic approaches to glycemic treatment: standards of care in diabetes—2023 publication-title: Diabetes Care doi: 10.2337/dc23-S009 contributor: fullname: ElSayed – volume: 466 start-page: 451 issue: 7305 year: 2010 ident: 10.1016/j.molmet.2024.101956_bib19 article-title: Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5 publication-title: Nature doi: 10.1038/nature09291 contributor: fullname: Choi – volume: 8 start-page: 1224 issue: 10 year: 1994 ident: 10.1016/j.molmet.2024.101956_bib33 article-title: mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer publication-title: Genes Dev doi: 10.1101/gad.8.10.1224 contributor: fullname: Tontonoz – volume: 125 year: 2021 ident: 10.1016/j.molmet.2024.101956_bib18 article-title: Insulin resistance and insulin sensitizing agents publication-title: Metabolism doi: 10.1016/j.metabol.2021.154892 contributor: fullname: Mastrototaro – volume: 27 start-page: 1621 issue: 4 year: 2013 ident: 10.1016/j.molmet.2024.101956_bib29 article-title: Increased cGMP promotes healthy expansion and browning of white adipose tissue publication-title: Faseb J doi: 10.1096/fj.12-221580 contributor: fullname: Mitschke – volume: 71 start-page: 398 issue: 2 year: 2007 ident: 10.1016/j.molmet.2024.101956_bib12 article-title: Sulfonylureas and glinides exhibit peroxisome proliferator-activated receptor gamma activity: a combined virtual screening and biological assay approach publication-title: Mol Pharmacol doi: 10.1124/mol.106.024596 contributor: fullname: Scarsi – volume: 73 start-page: 169 issue: 2 year: 2024 ident: 10.1016/j.molmet.2024.101956_bib34 article-title: Adipose signals regulating distal organ health and disease publication-title: Diabetes doi: 10.2337/dbi23-0005 contributor: fullname: Gilani – volume: 9 issue: 2 year: 2020 ident: 10.1016/j.molmet.2024.101956_bib25 article-title: PPM1A controls diabetic gene programming through directly dephosphorylating PPARgamma at Ser273 publication-title: Cells doi: 10.3390/cells9020343 contributor: fullname: Khim – volume: 54 year: 2021 ident: 10.1016/j.molmet.2024.101956_bib42 article-title: A novel peroxisome proliferator-activated receptor gamma ligand improves insulin sensitivity and promotes browning of white adipose tissue in obese mice publication-title: Mol Metabol doi: 10.1016/j.molmet.2021.101363 contributor: fullname: Wu – volume: 10 start-page: 596 issue: 7 year: 2008 ident: 10.1016/j.molmet.2024.101956_bib7 article-title: Glimepiride as insulin sensitizer: increased liver and muscle responses to insulin publication-title: Diabetes Obes Metabol doi: 10.1111/j.1463-1326.2008.00870.x contributor: fullname: Mori – volume: 128 start-page: 2600 issue: 6 year: 2018 ident: 10.1016/j.molmet.2024.101956_bib50 article-title: PPARgamma deacetylation dissociates thiazolidinedione's metabolic benefits from its adverse effects publication-title: J Clin Invest doi: 10.1172/JCI98709 contributor: fullname: Kraakman – volume: 11 year: 2020 ident: 10.1016/j.molmet.2024.101956_bib23 article-title: PPARgamma S273 phosphorylation modifies the dynamics of coregulator proteins recruitment publication-title: Front Endocrinol doi: 10.3389/fendo.2020.561256 contributor: fullname: Dias – volume: 29 start-page: 673 issue: 6 year: 1990 ident: 10.1016/j.molmet.2024.101956_bib47 article-title: Pharmacokinetic and pharmacodynamic studies of glibenclamide in non-insulin dependent diabetes mellitus publication-title: Br J Clin Pharmacol doi: 10.1111/j.1365-2125.1990.tb03688.x contributor: fullname: Coppack – volume: 77 start-page: 289 year: 2008 ident: 10.1016/j.molmet.2024.101956_bib14 article-title: Fat and beyond: the diverse biology of PPARgamma publication-title: Annu Rev Biochem doi: 10.1146/annurev.biochem.77.061307.091829 contributor: fullname: Tontonoz – volume: 517 start-page: 391 issue: 7534 year: 2015 ident: 10.1016/j.molmet.2024.101956_bib21 article-title: An ERK/Cdk5 axis controls the diabetogenic actions of PPARgamma publication-title: Nature doi: 10.1038/nature13887 contributor: fullname: Banks – volume: 4 start-page: 1769 year: 2013 ident: 10.1016/j.molmet.2024.101956_bib31 article-title: miR-155 regulates differentiation of brown and beige adipocytes via a bistable circuit publication-title: Nat Commun doi: 10.1038/ncomms2742 contributor: fullname: Chen – volume: 23 issue: 9 year: 2020 ident: 10.1016/j.molmet.2024.101956_bib37 article-title: Glyburide regulates UCP1 expression in adipocytes independent of K(ATP) channel blockade publication-title: iScience doi: 10.1016/j.isci.2020.101446 contributor: fullname: Qiu – volume: 16 start-page: 5659 issue: 21 year: 2006 ident: 10.1016/j.molmet.2024.101956_bib44 article-title: Design and synthesis of novel N-sulfonyl-2-indole carboxamides as potent PPAR-gamma binding agents with potential application to the treatment of osteoporosis publication-title: Bioorg Med Chem Lett doi: 10.1016/j.bmcl.2006.08.003 contributor: fullname: Hopkins – volume: 95 start-page: 4333 issue: 8 year: 1998 ident: 10.1016/j.molmet.2024.101956_bib32 article-title: ADD1/SREBP1 activates PPARgamma through the production of endogenous ligand publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.95.8.4333 contributor: fullname: Kim – volume: 477 start-page: 477 issue: 7365 year: 2011 ident: 10.1016/j.molmet.2024.101956_bib20 article-title: Antidiabetic actions of a non-agonist PPARgamma ligand blocking Cdk5-mediated phosphorylation publication-title: Nature doi: 10.1038/nature10383 contributor: fullname: Choi – volume: 609 start-page: 361 issue: 7926 year: 2022 ident: 10.1016/j.molmet.2024.101956_bib28 article-title: Apoptotic brown adipocytes enhance energy expenditure via extracellular inosine publication-title: Nature doi: 10.1038/s41586-022-05041-0 contributor: fullname: Niemann – volume: 55 start-page: 563 issue: 4 year: 1998 ident: 10.1016/j.molmet.2024.101956_bib46 article-title: Glimepiride. A review of its use in the management of type 2 diabetes mellitus publication-title: Drugs doi: 10.2165/00003495-199855040-00007 contributor: fullname: Langtry – volume: 5 issue: 10 year: 2008 ident: 10.1016/j.molmet.2024.101956_bib36 article-title: Chronic antidiabetic sulfonylureas in vivo: reversible effects on mouse pancreatic beta-cells publication-title: PLoS Med doi: 10.1371/journal.pmed.0050206 contributor: fullname: Remedi – volume: 299 issue: 4 year: 2023 ident: 10.1016/j.molmet.2024.101956_bib41 article-title: Selective PPARgamma modulator diosmin improves insulin sensitivity and promotes browning of white fat publication-title: J Biol Chem doi: 10.1016/j.jbc.2023.103059 contributor: fullname: Yu – volume: 176 start-page: 478 issue: 3 year: 2019 ident: 10.1016/j.molmet.2024.101956_bib48 article-title: Hypoglycaemic effects of glimepiride in sulfonylurea receptor 1 deficient rat publication-title: Br J Pharmacol doi: 10.1111/bph.14553 contributor: fullname: Zhou – volume: 10 start-page: 1577 issue: 5 year: 2019 ident: 10.1016/j.molmet.2024.101956_bib51 article-title: Glucocrinology of modern sulfonylureas: clinical evidence and practice-based opinion from an international expert group publication-title: Diabetes Ther doi: 10.1007/s13300-019-0651-1 contributor: fullname: Kalra – volume: 280 start-page: 23653 issue: 25 year: 2005 ident: 10.1016/j.molmet.2024.101956_bib8 article-title: Sulfonylurea agents exhibit peroxisome proliferator-activated receptor gamma agonistic activity publication-title: J Biol Chem doi: 10.1074/jbc.M412113200 contributor: fullname: Fukuen – volume: 2 start-page: ra78 issue: 99 year: 2009 ident: 10.1016/j.molmet.2024.101956_bib30 article-title: Protein kinase G controls brown fat cell differentiation and mitochondrial biogenesis publication-title: Sci Signal doi: 10.1126/scisignal.2000511 contributor: fullname: Haas |
SSID | ssj0000866651 |
Score | 2.3759768 |
Snippet | Sulfonylureas (SUs) are still among the mostly prescribed antidiabetic drugs with an established mode of action: release of insulin from pancreatic β-cells. In... • Sulfonylureas (SUs) inhibit PPARγ serine 273 phosphorylation in primary human adipocytes and in adipose tissue of obese mice. • SUs exhibit a positive... Objective: Sulfonylureas (SUs) are still among the mostly prescribed antidiabetic drugs with an established mode of action: release of insulin from pancreatic... |
SourceID | doaj pubmedcentral proquest crossref pubmed elsevier |
SourceType | Open Website Open Access Repository Aggregation Database Index Database Publisher |
StartPage | 101956 |
SubjectTerms | Brown adipose tissue Original PPARγ Sulfonylureas White adipose tissue |
SummonAdditionalLinks | – databaseName: Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3NatwwEBYhUMilNE3abNMWBXI1tawf28dt6RIKCUuShdyEJY1Yl9a7ZHcP-1x9jz5TR5a9eJtDLgH7IhlZmpE0n-xvZgi5RKtRZJznCfNgE1EKSExgEQrHueHSpF4Ff-frG3U1Ez8e5MMg1VfghMXwwFFwX4Bb5W2VO5PjhquckZlHjJwxlVnmbXTdY3JwmGr34AJhuWS9r1xL6PodOP6BPpmJUFSGnNUDW9SG7N8zSU8h5__MyYEpmrwhrzsMScex78fkAJq35FXMKrk9IfO7zS-_I5zTkFRpTVGAdfzOWlsanRkoXpWrlwu7RbxJzZbWzbw2dazzdDod3_79Q1etgyBFAEKX88UK78dtJNCdktnk-_23q6RLqJBYXgqVeEiNtdLK0oXA8r5ikCOks4WTaVYqI22ZA4PUMmZsKfCoIYA56aDIICug4u_IYbNo4IxQw1yFEnYFODzAWW5k5ZVxLAePWwJXI5L0otXLGDdD94SynzqqQgdV6KiKEfka5L97NkS9bgtwLuhuLujn5sKI5L32dAcgIjDApupnXn_RK1vj-go_TaoGFpuVxv1QCM6FwtbfR-XvOsmLnEtepiNS7E2LvVHs1zT1vI3hHSxViN724SXGfU6Owlgii_gjOVw_buATYqW1-dwui3_ZLBWk priority: 102 providerName: Directory of Open Access Journals – databaseName: ScienceDirect Free and Delayed Access Journal dbid: IXB link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9wwEBYhEOiltOlr0wcq9GrWsh62j0loCIWW0DSwN2G9uiqtvezjsL-r_6O_qTOWvcTtoVCwD5ZkWZ6RZ0byNzOEvAOtURWclxkL3maiFj4ziCIUjnPDpcmDQn_nj5_U9Z34sJCLI3I5-sIgrHKQ_Umm99J6KJkP1JyvYpzfFiB1qxI0nMj7uOwghzG2JzrxLS4O-yxgsivVZ2HE9hneMHrQ9TCvH4j8R1BlIbCoxkzW9zRUH8h_oqj-NkT_xFPeU1BXj8jDwbKk52nwj8mRb0_JSco1uX9Clre77-EAQ6eYamlLgawx7b5GS5OLA4WjcXHV2T1YodTsaWyX0cRUF-jNzfnnXz_ppncbpGCW0NWy28C53idY3VNyd_X-y-V1NqRZyCyvhcqCz4210sraYbj50DBfgqFnKyfzolZG2rr0zOeWMWNrAQsQ4ZmTzleFLyrf8GfkuO1a_4JQw1wD1HaVd7Css9zIJijjWOkDCAquZiQbSatXKZqGHmFm33RihUZW6MSKGblA-h_aYizsvqBbf9XDZNCeWxVsUzpTgkpWzsgiwCqqYKqwLNh6RsqRe3oytaCr-I_Hvx2ZreGrw18pTeu73UaDlBSCc6Gg9-eJ-YdB8qrkktf5jFSTaTF5i2lNG5d9ZG_UXxjT7ey_h_ySPMCrBCh-RY63651_DWbT1rzpv4vfnMMYNw priority: 102 providerName: Elsevier – databaseName: Scholars Portal Journals: Open Access(OpenAccess) dbid: M48 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhV1bi9QwFD6sK8q-iHfHGxF8rUyubR9EVnFZhJVFHdi30NycytqOcwH7u_wf_iZPmnbcURehfUnaND3nJOdL--UcgOfoNQrGeZ7R4G0mSuEzE1mEwnFuuDTToOJ-55P36ngm3p3Jsz0Yc7YOAlz9c2kX80nNlucvvn_rXuGAf_mbq_U10vcjM5KJWISY_wpcZYKLaPMnA-Dv5-YC4bqk4x66S24-gOu8yLnkcaa-4K76qP47XutvVPonufKCtzq6CTcGmEkOk13cgj3f3IZrKfFkdwfmHzfnYctJJzHv0pqgjOv0Kba2JO13IHhUrl60tkNISkxH6mZemzrVBXJ6evjh5w-y6vcQEsQoZDFvV3guu8Sxuwuzo7ef3hxnQ86FzPJSqCz4qbFWWlm6GHs-VNTniPps4eSUlcpIW-ae-qml1NhS4GpEeOqk8wXzrPAVvwf7Tdv4B0AMdRUK2xXe4RrPciOroIyjuQ84a3A1gWwUrV6k0Bp65Jx90UkrOmpFJ61M4HWU__baGBi7L2iXn_UwzrTnVgVb5c7k6J-VM5IFXFIxqpilwZYTyEft6QFjJOyATdX_efyzUdkah2D8r1I1vt2sNE6ZQnA0Nmz9flL-tpOjHU2g2DGLnbfYrWnqeR_mOzqzGODt4aWNPoKD2MHEHn4M--vlxj9BjLQ2T3uz_wWgShFt priority: 102 providerName: Scholars Portal |
Title | Sulfonylureas exert antidiabetic action on adipocytes by inhibition of PPARγ serine 273 phosphorylation |
URI | https://dx.doi.org/10.1016/j.molmet.2024.101956 https://www.ncbi.nlm.nih.gov/pubmed/38735390 https://www.proquest.com/docview/3054433469/abstract/ https://pubmed.ncbi.nlm.nih.gov/PMC11112612 https://doaj.org/article/e3c6fca7db73416db52f5762162c1fc9 |
Volume | 85 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1ba9swFBZtx2AvY_dll6DBXt1Y1sX2YxtWukG6sK0Q9iKsW-PR2CGXh_yu_o_-ph1JcUi2h8HA1oNky5KOpPNJ_s4RQh9BaxQZpXlCnNUJK5lNlGcRMkOpolylTnh759GVuLxmXyZ8coREZwsTSPta1afN7ey0qaeBWzmf6UHHExuMR0M_zL3rq8ExOs4p3Vujh_m3AEjOSWcnF8hcM8_v99TJjPmo0p9XvaeHgrv-A3X0N9z8kzW5p4YunqDHW_yIz2I5n6Ij2zxDD-OJkpvnaPp9fet2ZHPsD1RaYWi8Ou6x1hpHQwYMV2Xqeas3gDWx2uC6mdaqjmkOj8dn3-7v8DIYB2IAH3g-bZdwLzaRPPcCXV98-jG8TLaHKSSalkwkzqZKa655abxTeVcRmwOc04XhaVYKxXWZW2JTTYjSJYNlBrPEcGOLzGaFrehLdNK0jX2NsCKmghY2hTWweNNU8coJZUhuHUwHVPRQ0jWtnEefGbIjk_2SURTSi0JGUfTQuW__3bPe43WIaBc3cit3aakWTle5UTkoXmEUzxyslTIiMk2cLnso76Qnt-AhggLIqv7H5z90wpYwtvwPk6qx7XopYS5kjFImIPdXUfi7QtIip5yWaQ8VB93ioBaHKdCdg__urvu--f9X36JHvgaRN_wOnawWa_se0NFK9cOuAoSfJ-cQjljRRw-uhpOvP_thmPwG4XYYtw |
link.rule.ids | 230,315,733,786,790,870,891,2115,3525,24346,27955,27956,45907,53825,53827 |
linkProvider | National Library of Medicine |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELZKEaIXxLvL00hco43jR5JjW1Et0FYVbaW9WfGLNaLJah-H_V39H_1NHcfJqoEDElJysWPHmbFnxs43Mwh9Bq1RZJTmCXFWJ6xkNlEBRcgMpYpylToR_J1Pz8Tkin2b8ukOOup9YQKsspP9Uaa30rorGXfUHM-9H19kIHWLHDQcS9u47A_QQ8Zhrxe8-KaH24MWsNmFaNMwhgZJaNG70LU4r-sA_Q-oyoyFojKksr6notpI_gNN9bcl-ieg8p6GOn6KnnSmJT6Io3-Gdmz9HD2KySY3L9DsYv3bbXHoOORaWmGgq4_Hr17j6OOA4aqMnzd6A2YoVhvs65lXPtY5fH5-8OP2Bi9bv0EMdgmez5ol3ItNxNW9RFfHXy6PJkmXZyHRtGQicTZVWnPNSxPizbuK2BwsPV0YnmalUFyXuSU21YQoXTLYgTBLDDe2yGxW2Iq-Qrt1U9t9hBUxFVDbFNbAvk5TxSsnlCG5dSApqBihpCetnMdwGrLHmf2SkRUysEJGVozQYaD_9tkQDLstaBY_ZTcbpKVaOF3lRuWgk4VRPHOwjcqIyDRxuhyhvOeeHMwt6Mr_4_WfemZLWHbhX0pV22a9lCAmGaOUCej9dWT-dpC0yCmnZTpCxWBaDL5iWFP7WRvaOyiwENTtzX8P-SN6PLk8PZEnX8--v0V7oSaii9-h3dVibd-DDbVSH9o1cge-hBtc |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Jb9QwFLagCMSFfRlWI3HNTBwvSY6lMCpLqxFQqRIHK96YtJ0kmuUw_C3-B7-J5zgZzZQDUqXkYjtOnPfs9zn53nsIvQWrkSWUphFxVkcsZzZSnkXIDKWKchU74f2dj47F4Qn7dMpPO1bloqNVVlqVw-piNqzKacutbGZ61PPERpOjAz_NfeirUWPc6Dq6AZM2Sbd26u0qnAEw56T3lmspXTPP8vcEyoT5otxnrd6yRm3Q_h2j9C_ovMyd3DJG47voRz-MwEE5H66Waqh_XYrweLVx3kN3OoyK90Ob--iarR6gmyFr5fohmn5bXbgNoR37pE1LDAIqw3fcUuPgLIHhKEzZ1HoNeBarNS6raanKUOfwZLL_9c9vvGgdEDEAHNxM6wWc83Ug6D1CJ-MP3w8Ooy5hQ6RpzkTkbKy05prnxgeudwWxKUBGnRkeJ7lQXOepJTbWhCidM9jKMEsMNzZLbJLZgj5Ge1Vd2acIK2IKkJ_JrIENoqaKF04oQ1LrYMmhYoCiXnCyCXE5ZE9YO5NB0NILWgZBD9A7L91NWx9Vuy2o5z9l986lpVo4XaRGpWDchVE8cbAfS4hINHE6H6C01w3ZAZQAPKCr8j-3f9OrkoT563_KFJWtVwsJ6y1jlDIBvT8JqrV5SJqllNM8HqBsR-l2RrFbA6rUxgjvVefZ1S99jW5N3o_ll4_Hn5-j234wgab8Au0t5yv7EsDYUr1qZ91fTCo4xQ |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Sulfonylureas+exert+antidiabetic+action+on+adipocytes+by+inhibition+of+PPAR%CE%B3+serine+273+phosphorylation&rft.jtitle=Molecular+metabolism+%28Germany%29&rft.au=Haas%2C+Bodo&rft.au=Hass%2C+Moritz+David+Sebastian&rft.au=Voltz%2C+Alexander&rft.au=Vogel%2C+Matthias&rft.date=2024-07-01&rft.eissn=2212-8778&rft.volume=85&rft.spage=101956&rft_id=info:doi/10.1016%2Fj.molmet.2024.101956&rft_id=info%3Apmid%2F38735390&rft.externalDocID=38735390 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2212-8778&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2212-8778&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2212-8778&client=summon |