Adrenergic reactions during N3 sleep arousals in sleepwalking and sleep terrors: The chicken or the egg?

• Published in: Journal of sleep research Vol. 29; no. 6; pp. e12946 - n/a
• Main Authors: Ledard, Nahema, Artru, Emilie, Colmenarez Sayago, Patricia, Redolfi, Stefania, Golmard, Jean‐Louis, Carrillo‐Solano, Marisol, Arnulf, Isabelle
• Format: Journal Article
• Language: English
• Published: England Wiley 01.12.2020
• Subjects: Adult; Autonomic Nervous System - metabolism; autonomic system; Female; Humans; Life Sciences; Male; night terrors; Night Terrors - physiopathology; nightmare; parasomnia; Parasomnias - physiopathology; Polysomnography - methods; Sleep, Slow-Wave - physiology; sleepwalking; Somnambulism - physiopathology; tachycardia; autonomic system; parasomnia; tachycardia; night terrors; nightmare; sleepwalking
• ISSN: 0962-1105; 1365-2869; 1365-2869
• DOI: 10.1111/jsr.12946

To understand the mechanisms of N3 sleep interruptions in patients with sleepwalking episodes and/or sleep terrors (SW/ST), we evaluated whether autonomic reactions preceded or accompanied behavioural arousals from NREM sleep stage N3. In 20 adult patients with SW/ST and 20 matched controls without parasomnia, heart rate and pulse wave amplitude were measured beat‐to‐beat during the 10 beats preceding and during the 15 beats succeeding a motor arousal from N3 sleep. Respiratory rate and amplitude were measured during the same 25 successive beats. In patients with SW/ST, the N3 arousals were associated with a 33% increase in heart rate, a 57% decrease in pulse wave amplitude (indicating a major vasoconstriction), a 24% increase in respiratory rate and a doubling of respiratory amplitude. Notably, tachycardia and vasoconstriction started 4 s before motor arousals. A similar profile (tachycardia and vasoconstriction gradually increasing from the 4 s preceding arousal and post‐arousal increase of respiratory amplitude, but no polypnea) was also observed, with a lower amplitude, during the less frequent 38 quiet N3 arousals in control subjects. Parasomniac arousals were associated with greater tachycardia, vasoconstriction and polypnea than quiet arousals, with the same pre‐arousal gradual increases in heart rate and vasoconstriction. Autonomic arousal occurs 4 s before motor arousal from N3 sleep in patients with SW/ST (with a higher adrenergic reaction than in controls), suggesting that an alarming event during sleep (possibly a worrying sleep mentation or a local subcortical arousal) causes the motor arousal.