IL‐10 Promoter −1082 Polymorphism is Associated with Elevated IL‐10 Levels in Control Subjects but Does not Explain Elevated Plasma IL‐10 Observed in Sjögren's Syndrome in a Hungarian Cohort

• Published in: Scandinavian journal of immunology Vol. 62; no. 5; pp. 474 - 480
• Main Authors: Márka, M., Bessenyei, B., Zeher, M., Semsei, I.
• Format: Journal Article
• Language: English
• Published: Oxford, UK; Malden, USA Blackwell Science Ltd 01.11.2005; Wiley Subscription Services, Inc
• Subjects: Adult; Aged; Cohort Studies; Female; Gene Frequency; Genotype; Heterozygote; Homozygote; Humans; Hungary; Interleukin-10 - blood; Interleukin-10 - genetics; Male; Middle Aged; Polymorphism, Single Nucleotide - genetics; Promoter Regions, Genetic - genetics; Sjogren's Syndrome - blood; Sjogren's Syndrome - genetics; Hungary

The aim of this study was to investigate the frequency of the −1082 polymorphism of the interleukin‐10 (IL‐10) gene and the soluble IL‐10 levels in Hungarian primary Sjögren's syndrome (SS) patients. Ninety‐nine SS patients and 135 healthy volunteers were examined. Samples were analysed by the...