Inhibition of thyroid-restricted genes by follicular thyroglobulin involves iodinated degree
Follicular thyroglobulin (TG) reflects the storage of both iodine and thyroid hormone. This is because it is a macromolecular precursor of thyroid hormone and organic iodinated compound in follicular lumen. Thus, it may have an important feedback role in thyroid function. In this study, monolayer ce...
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| Published in | Journal of cellular biochemistry Vol. 112; no. 3; pp. 971 - 977 |
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| Abstract | Follicular thyroglobulin (TG) reflects the storage of both iodine and thyroid hormone. This is because it is a macromolecular precursor of thyroid hormone and organic iodinated compound in follicular lumen. Thus, it may have an important feedback role in thyroid function. In this study, monolayer cells were cultured and follicles were reconstituted with primary pig thyroid cells in vitro. Reconstituted follicles were treated with iodine and methimazole (MMI), a drug that blocks iodine organification and reduces the degree of TG iodination in follicular lumen. The high degree of iodinated TG in follicular lumen was observed to inhibit thyroid‐restricted gene expression. To confirm this finding, monolayer thyroid cells were treated with a different degree of TG iodination at the same concentration. These iodinated TG were extracted from reconstituted follicles of different groups. In this manner, this study provides firsthand evidence suggesting that follicular TG inhibits the expressions of thyroid‐restricted genes NIS, TPO, TG, and TSHr. J. Cell. Biochem. 112: 971–977, 2011. © 2011 Wiley‐Liss, Inc. |
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| AbstractList | Follicular thyroglobulin (TG) reflects the storage of both iodine and thyroid hormone. This is because it is a macromolecular precursor of thyroid hormone and organic iodinated compound in follicular lumen. Thus, it may have an important feedback role in thyroid function. In this study, monolayer cells were cultured and follicles were reconstituted with primary pig thyroid cells in vitro. Reconstituted follicles were treated with iodine and methimazole (MMI), a drug that blocks iodine organification and reduces the degree of TG iodination in follicular lumen. The high degree of iodinated TG in follicular lumen was observed to inhibit thyroid-restricted gene expression. To confirm this finding, monolayer thyroid cells were treated with a different degree of TG iodination at the same concentration. These iodinated TG were extracted from reconstituted follicles of different groups. In this manner, this study provides firsthand evidence suggesting that follicular TG inhibits the expressions of thyroid-restricted genes NIS, TPO, TG, and TSHr. J. Cell. Biochem. 112: 971-977, 2011. [copy 2011 Wiley-Liss, Inc. Follicular thyroglobulin (TG) reflects the storage of both iodine and thyroid hormone. This is because it is a macromolecular precursor of thyroid hormone and organic iodinated compound in follicular lumen. Thus, it may have an important feedback role in thyroid function. In this study, monolayer cells were cultured and follicles were reconstituted with primary pig thyroid cells in vitro. Reconstituted follicles were treated with iodine and methimazole (MMI), a drug that blocks iodine organification and reduces the degree of TG iodination in follicular lumen. The high degree of iodinated TG in follicular lumen was observed to inhibit thyroid‐restricted gene expression. To confirm this finding, monolayer thyroid cells were treated with a different degree of TG iodination at the same concentration. These iodinated TG were extracted from reconstituted follicles of different groups. In this manner, this study provides firsthand evidence suggesting that follicular TG inhibits the expressions of thyroid‐restricted genes NIS, TPO, TG, and TSHr. J. Cell. Biochem. 112: 971–977, 2011. © 2011 Wiley‐Liss, Inc. Follicular thyroglobulin (TG) reflects the storage of both iodine and thyroid hormone. This is because it is a macromolecular precursor of thyroid hormone and organic iodinated compound in follicular lumen. Thus, it may have an important feedback role in thyroid function. In this study, monolayer cells were cultured and follicles were reconstituted with primary pig thyroid cells in vitro. Reconstituted follicles were treated with iodine and methimazole (MMI), a drug that blocks iodine organification and reduces the degree of TG iodination in follicular lumen. The high degree of iodinated TG in follicular lumen was observed to inhibit thyroid-restricted gene expression. To confirm this finding, monolayer thyroid cells were treated with a different degree of TG iodination at the same concentration. These iodinated TG were extracted from reconstituted follicles of different groups. In this manner, this study provides firsthand evidence suggesting that follicular TG inhibits the expressions of thyroid-restricted genes NIS, TPO, TG, and TSHr.Follicular thyroglobulin (TG) reflects the storage of both iodine and thyroid hormone. This is because it is a macromolecular precursor of thyroid hormone and organic iodinated compound in follicular lumen. Thus, it may have an important feedback role in thyroid function. In this study, monolayer cells were cultured and follicles were reconstituted with primary pig thyroid cells in vitro. Reconstituted follicles were treated with iodine and methimazole (MMI), a drug that blocks iodine organification and reduces the degree of TG iodination in follicular lumen. The high degree of iodinated TG in follicular lumen was observed to inhibit thyroid-restricted gene expression. To confirm this finding, monolayer thyroid cells were treated with a different degree of TG iodination at the same concentration. These iodinated TG were extracted from reconstituted follicles of different groups. In this manner, this study provides firsthand evidence suggesting that follicular TG inhibits the expressions of thyroid-restricted genes NIS, TPO, TG, and TSHr. Follicular thyroglobulin (TG) reflects the storage of both iodine and thyroid hormone. This is because it is a macromolecular precursor of thyroid hormone and organic iodinated compound in follicular lumen. Thus, it may have an important feedback role in thyroid function. In this study, monolayer cells were cultured and follicles were reconstituted with primary pig thyroid cells in vitro. Reconstituted follicles were treated with iodine and methimazole (MMI), a drug that blocks iodine organification and reduces the degree of TG iodination in follicular lumen. The high degree of iodinated TG in follicular lumen was observed to inhibit thyroid-restricted gene expression. To confirm this finding, monolayer thyroid cells were treated with a different degree of TG iodination at the same concentration. These iodinated TG were extracted from reconstituted follicles of different groups. In this manner, this study provides firsthand evidence suggesting that follicular TG inhibits the expressions of thyroid-restricted genes NIS, TPO, TG, and TSHr. |
| Author | Shi, Yaxiong Lin, Xiahong Xu, Dongming Li, Liangyi Li, Xisheng Lin, Ling Huang, Huibin |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/21308730$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1016_j_pharma_2012_01_003 crossref_primary_10_3389_fendo_2023_1234918 crossref_primary_10_1155_2016_2492450 crossref_primary_10_1007_s12011_017_0960_z crossref_primary_10_1089_thy_2015_0338 crossref_primary_10_3892_br_2016_596 crossref_primary_10_3892_br_2016_721 crossref_primary_10_1093_toxsci_kfad133 crossref_primary_10_1002_jcb_26001 crossref_primary_10_3389_fendo_2022_992883 crossref_primary_10_3803_EnM_2021_1070 crossref_primary_10_1111_cen_13543 crossref_primary_10_1007_s12011_017_1017_z |
| Cites_doi | 10.1017/S1431927607076611 10.1677/joe.0.1670125 10.1016/S0300-9084(99)80078-9 10.1111/j.1768-322X.1998.tb01046.x 10.1056/NEJMoa054022 10.1073/pnas.77.6.3455 10.1677/joe.1.06677 10.1055/s-2003-42721 10.1111/j.1432-1033.1992.tb17267.x 10.1210/endo.140.11.7124 10.1074/jbc.274.35.25099 10.1210/endo.138.6.5195 10.1113/expphysiol.2010.054700 10.1210/jc.82.10.3331 10.1210/endo-118-6-2477 10.1677/joe.1.05643 10.1089/thy.1999.9.319 10.1210/en.2002-220981 10.1210/endo.131.3.1505456 10.1210/en.2005-0805 10.1016/j.bbrc.2009.11.158 10.1089/105072501300176417 10.1073/pnas.94.11.5568 |
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Teng W, Shan Z, Teng X, Guan H, Li Y, Teng D, Jin Y, Yu X, Fan C, Chong W, et al. 2006. Effect of iodine intake on thyroid diseases in China. N Engl J Med 354: 2783-2793. Suzuki K, Mori A, Lavaroni S, Ulianich L, Miyagi E, Saito J, Nakazato M, Pietrarelli M, Shafran N, Grassadonia A, Kim W.B, Consiglio E, Formisano S, Kohn LD. 1999b. Thyroglobulin regulates follicular function and heterogeneity by suppressing thyroid-specific gene expression. Biochimie 81: 329-340. Mauchamp J, Mirrione A, Alquier C, Andre F. 1998. Follicle-like structure and polarized monolayer: Role of the extracellular matrix on thyroid cell organization in primary culture. Biol Cell 90: 369-380. Suzuki K, Mori A, Lavaroni S, Miyagi E, Ulianich L, Katoh R, Kawaoi A, Kohn LD. 1999a. 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| References_xml | – reference: Noguchi Y, Harii N, Giuliani C, Tatsuno I, Suzuki K, Kohn LD. 2010. Thyroglobulin (Tg) induces thyroid cell growth in a concentration-specific manner by a mechanism other than thyrotropin/cAMP stimulation. Biochem Biophys Res Commun 391: 890-894. – reference: Suzuki K, Mori A, Lavaroni S, Miyagi E, Ulianich L, Katoh R, Kawaoi A, Kohn LD. 1999a. In vivo expression of thyroid transcription factor-1 RNA and its relation to thyroid function and follicular heterogeneity: Identification of follicular thyroglobulin as a feedback suppressor of thyroid transcription factor-1 RNA levels and thyroglobulin synthesis. Thyroid 9: 319-331. – reference: Lemansky P, Herzog V. 1992. Endocytosis of thyroglobulin is not mediated by mannose-6-phosphate receptors in thyrocytes. Evidence for low-affinity-binding sites operating in the uptake of thyroglobulin. Eur J Biochem 209: 111-119. – reference: Suzuki K, Kohn LD. 2006. Differential regulation of apical and basal iodide transporters in the thyroid by thyroglobulin. J Endocrinol 189: 247-255. – reference: Levy O, Dai G, Riedel C, Ginter CS, Paul EM, Lebowitz AN, Carrasco N. 1997. Characterization of the thyroid Na+/I symporter with an anti-COOH terminus antibody. Proc Natl Acad Sci USA 94: 5568-5573. – reference: Suzuki K, Mori A, Saito J, Moriyama E, Ullianich L, Kohn LD. 1999c. Follicular thyroglobulin suppresses iodide uptake by suppressing expression of the sodium/iodide symporter gene. Endocrinology 140: 5422-5430. – reference: Takasu N, Ohno S, Komiya I, Yamada T. 1992. Requirements of follicle structure for thyroid hormone synthesis; Cytoskeletons and iodine metabolism in polarized monolayer cells on collagen gel and in double layered, follicle-forming cells. Endocrinology 131: 1143-1148. – reference: Grollman EF, Smolar A, Ommaya A, Tombaccini D, Santisteban P. 1986. Iodine suppression of iodide uptake in FRTL-5 thyroid cells. 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Proc Natl Acad Sci USA 77: 3455-3459. – reference: Saito T, Endo T, Kawaguchi A, Ikeda M, Nakazato M, Kogai T, Onaya T. 1997. Increased expression of the Na+/I-symporter in cultured human thyroid cells exposed to thyrotropin and in Graves' thyroid tissue. J Clin Endocrinol Metab 82: 3331-3336. – reference: Ferreira AC, Lima LP, Araujo RL, Muller G, Rocha RP, Rosenthal D, Carvalho DP. 2005. Rapid regulation of thyroid sodium-iodide symporter activity by thyrotrophin and iodine. J Endocrinol 184: 69-76. – reference: Li H, Ganta S, Fong P. 2010. Altered ion transport by thyroid epithelia from CFTR−/− pigs suggests mechanisms for hypothyroidism in cystic fibrosis. Exp Physiol. 95: 1132-1144. – reference: Morand S, Chaaraoui M, Kaniewski J, Deme D, Ohayon R, Noel-Hudson MS, Virion A, Dupuy C. 2003. Effect of iodide on nicotinamide adenine dinucleotide phosphate oxidase activity and Duox2 protein expression in isolated porcine thyroid follicles. 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| SubjectTerms | Animals Antithyroid Agents - pharmacology Cell Culture Techniques Cells, Cultured Down-Regulation iodinated thyroglobulin Iodine - pharmacology Methimazole - pharmacology Organ Specificity Protein Binding Protein Biosynthesis Receptors, Thyrotropin - genetics Receptors, Thyrotropin - metabolism reconstituted thyroid follicles sodium iodide symporter Swine Symporters - genetics Symporters - metabolism Thyroglobulin - pharmacology Thyroglobulin - physiology Thyroid Gland - cytology Thyroid Gland - drug effects Thyroid Gland - metabolism thyroid peroxidase thyrotropin receptor |
| Title | Inhibition of thyroid-restricted genes by follicular thyroglobulin involves iodinated degree |
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