Circadian rhythms, the mesolimbic dopaminergic circuit, and drug addiction

• Published in: TheScientificWorld Vol. 7; pp. 194 - 202
• Main Author: McClung, Colleen A
• Format: Journal Article
• Language: English
• Published: United States TheScientificWorldJOURNAL 02.11.2007; Hindawi Limited
• Subjects: Animals; Behavior - drug effects; Behavior, Animal - drug effects; Circadian Rhythm - drug effects; CLOCK Proteins; Dopamine - metabolism; Humans; Mini-Review; Substance-Related Disorders - metabolism; Trans-Activators - genetics; Trans-Activators - metabolism

Drug addiction is a devastating disease that affects millions of individuals worldwide. Through better understanding of the genetic variations that create a vulnerability for addiction and the molecular mechanisms that underlie the progression of addiction, better treatment options can be created fo...