Virucidal activity and mechanism of action of cetylpyridinium chloride against SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogen causing the coronavirus disease 2019 (COVID-19) global pandemic. Recent studies have shown the importance of the throat and salivary glands as sites of virus replication and transmission. The viral host receptor, angiotensi...
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| Published in | Journal of oral and maxillofacial surgery, medicine, and pathology Vol. 34; no. 6; pp. 800 - 804 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier Ltd
01.11.2022
sian AOMS, ASOMP, JSOP, JSOMS, JSOM, and JAMI. Published by Elsevier Ltd |
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| Abstract | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogen causing the coronavirus disease 2019 (COVID-19) global pandemic. Recent studies have shown the importance of the throat and salivary glands as sites of virus replication and transmission. The viral host receptor, angiotensin-converting enzyme 2 (ACE2), is broadly enriched in epithelial cells of the salivary glands and oral mucosae. Oral care products containing cetylpyridinium chloride (CPC) as a bactericidal ingredient are known to exhibit antiviral activity against SARS-CoV-2 in vitro. However, the exact mechanism of action remains unknown.
This study examined the antiviral activity of CPC against SARS-CoV-2 and its inhibitory effect on the interaction between the viral spike (S) protein and ACE2 using an enzyme-linked immunosorbent assay.
CPC (0.05%, 0.1% and 0.3%) effectively inactivated SARS-CoV-2 within the contact times (20 and 60 s) in directions for use of oral care products in vitro. The binding ability of both the S protein and ACE2 were reduced by CPC.
Our results suggest that CPC inhibits the interaction between S protein and ACE2, and thus, reduces infectivity of SARS-CoV-2 and suppresses viral adsorption. |
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| AbstractList | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogen causing the coronavirus disease 2019 (COVID-19) global pandemic. Recent studies have shown the importance of the throat and salivary glands as sites of virus replication and transmission. The viral host receptor, angiotensin-converting enzyme 2 (ACE2), is broadly enriched in epithelial cells of the salivary glands and oral mucosae. Oral care products containing cetylpyridinium chloride (CPC) as a bactericidal ingredient are known to exhibit antiviral activity against SARS-CoV-2 in vitro. However, the exact mechanism of action remains unknown.
This study examined the antiviral activity of CPC against SARS-CoV-2 and its inhibitory effect on the interaction between the viral spike (S) protein and ACE2 using an enzyme-linked immunosorbent assay.
CPC (0.05%, 0.1% and 0.3%) effectively inactivated SARS-CoV-2 within the contact times (20 and 60 s) in directions for use of oral care products in vitro. The binding ability of both the S protein and ACE2 were reduced by CPC.
Our results suggest that CPC inhibits the interaction between S protein and ACE2, and thus, reduces infectivity of SARS-CoV-2 and suppresses viral adsorption. ObjectiveSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogen causing the coronavirus disease 2019 (COVID-19) global pandemic. Recent studies have shown the importance of the throat and salivary glands as sites of virus replication and transmission. The viral host receptor, angiotensin-converting enzyme 2 (ACE2), is broadly enriched in epithelial cells of the salivary glands and oral mucosae. Oral care products containing cetylpyridinium chloride (CPC) as a bactericidal ingredient are known to exhibit antiviral activity against SARS-CoV-2 in vitro. However, the exact mechanism of action remains unknown. MethodsThis study examined the antiviral activity of CPC against SARS-CoV-2 and its inhibitory effect on the interaction between the viral spike (S) protein and ACE2 using an enzyme-linked immunosorbent assay. ResultsCPC (0.05%, 0.1% and 0.3%) effectively inactivated SARS-CoV-2 within the contact times (20 and 60 s) in directions for use of oral care products in vitro. The binding ability of both the S protein and ACE2 were reduced by CPC. ConclusionsOur results suggest that CPC inhibits the interaction between S protein and ACE2, and thus, reduces infectivity of SARS-CoV-2 and suppresses viral adsorption. |
| Author | Saito, Akatsuki Okabayashi, Tamaki Okamoto, Nako Komine, Akihiko |
| Author_xml | – sequence: 1 givenname: Nako surname: Okamoto fullname: Okamoto, Nako email: nako.okamoto@jp.sunstar.com organization: R&D, Sunstar Inc., 1-35-10, Kawanishi-cho, Takatsuki, Osaka 569-1133, Japan – sequence: 2 givenname: Akatsuki surname: Saito fullname: Saito, Akatsuki organization: Department of Veterinary Science, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan – sequence: 3 givenname: Tamaki surname: Okabayashi fullname: Okabayashi, Tamaki organization: Department of Veterinary Science, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan – sequence: 4 givenname: Akihiko surname: Komine fullname: Komine, Akihiko organization: R&D, Sunstar Inc., 1-35-10, Kawanishi-cho, Takatsuki, Osaka 569-1133, Japan |
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| Copyright | 2022 Asian AOMS, ASOMP, JSOP, JSOMS, JSOM, and JAMI 2022Asian AOMS, ASOMP, JSOP, JSOMS, JSOM, and JAMI. Published by Elsevier Ltd. All rights reserved. 2022Asian AOMS, ASOMP, JSOP, JSOMS, JSOM, and JAMI. Published by Elsevier Ltd. All rights reserved. 2022 Asian AOMS, ASOMP, JSOP, JSOMS, JSOM, and JAMI |
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| Keywords | COVID-19 Antiviral SARS-CoV-2 Virus inactivation Cetylpyridinium chloride virus inactivation cetylpyridinium chloride antiviral |
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| Title | Virucidal activity and mechanism of action of cetylpyridinium chloride against SARS-CoV-2 |
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